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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 2413

FusionGeneSummary for ARHGAP24_MAPK10

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP24_MAPK10
Fusion gene ID: 2413
HgeneTgene
Gene symbol

ARHGAP24

MAPK10

Gene ID

83478

5602

Gene nameRho GTPase activating protein 24mitogen-activated protein kinase 10
SynonymsFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAPJNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK
Cytomap

4q21.23-q21.3

4q21.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3
Modification date2018051920180524
UniProtAcc

Q8N264

P53779

Ensembl transtripts involved in fusion geneENST00000395184, ENST00000503995, 
ENST00000506421, ENST00000395183, 
ENST00000264343, 
ENST00000395169, 
ENST00000359221, ENST00000361569, 
ENST00000395166, ENST00000449047, 
ENST00000395161, ENST00000513839, 
ENST00000395157, ENST00000395160, 
Fusion gene scores* DoF score5 X 6 X 4=1205 X 5 X 6=150
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP24 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A6E0-01AARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
TCGARVSARCTCGA-SI-AA8C-01AARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
TCGALDSARCTCGA-SI-AA8C-01AARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000395184ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000395184ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000395184ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000503995ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000503995ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-intronENST00000395183ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-intronENST00000395183ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000264343ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000264343ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
In-frameENST00000395184ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395184ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000503995ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000503995ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395183ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395183ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000264343ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000264343ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395184ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395184ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000503995ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000503995ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-intronENST00000506421ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395183ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395183ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000264343ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000264343ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000264343ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000264343ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000264343ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-

Top

FusionProtFeatures for ARHGAP24_MAPK10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP24

Q8N264

MAPK10

P53779

Rho GTPase-activating protein involved in cell polarity,cell morphology and cytoskeletal organization. Acts as a GTPaseactivator for the Rac-type GTPase by converting it to an inactiveGDP-bound state. Controls actin remodeling by inactivating Racdownstream of Rho leading to suppress leading edge protrusion andpromotes cell retraction to achieve cellular polarity. Able tosuppress RAC1 and CDC42 activity in vitro. Overexpression inducescell rounding with partial or complete disruption of actin stressfibers and formation of membrane ruffles, lamellipodia, andfilopodia. Isoform 2 is a vascular cell-specific GAP involved inmodulation of angiogenesis. {ECO:0000269|PubMed:15302923,ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+51019_125199749DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+5619_125199247DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+51019_125199749DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+5619_125199247DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+27649_729106656Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+38649_729104654Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+510649_729199749Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+56649_729199247Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+27649_729106656Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+38649_729104654Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+510649_729199749Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+56649_729199247Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+27135_329106656DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+2719_125106656DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+38135_329104654DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+3819_125104654DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+510135_329199749DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+56135_329199247DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+27135_329106656DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+2719_125106656DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+38135_329104654DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+3819_125104654DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+510135_329199749DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+56135_329199247DomainRho-GAP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000359221-121464_359417465DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000361569-121464_359417423DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395160-7964_359272278DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395161-121464_359417423DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395166-121464_359379427DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395169-121464_359379427DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000359221-121464_359417465DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000361569-121464_359417423DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395160-7964_359272278DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395161-121464_359417423DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395166-121464_359379427DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395169-121464_359379427DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000359221-1214221_223417465MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000361569-1214221_223417423MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395160-79221_223272278MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395161-1214221_223417423MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395166-1214221_223379427MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395169-1214221_223379427MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000359221-1214221_223417465MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000361569-1214221_223417423MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395160-79221_223272278MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395161-1214221_223417423MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395166-1214221_223379427MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395169-1214221_223379427MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000359221-121470_78417465Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000361569-121470_78417423Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395160-7970_78272278Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395161-121470_78417423Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395166-121470_78379427Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395169-121470_78379427Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000359221-121470_78417465Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000361569-121470_78417423Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395160-7970_78272278Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395161-121470_78417423Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395166-121470_78379427Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395169-121470_78379427Nucleotide bindingNote=ATP


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FusionGeneSequence for ARHGAP24_MAPK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP24_MAPK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP24APPMAPK10MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP24_MAPK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP24_MAPK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource