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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24125

FusionGeneSummary for NF2_NF2

check button Fusion gene summary
Fusion gene informationFusion gene name: NF2_NF2
Fusion gene ID: 24125
HgeneTgene
Gene symbol

NF2

NF2

Gene ID

4771

4771

Gene nameneurofibromin 2neurofibromin 2
SynonymsACN|BANF|SCHACN|BANF|SCH
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionmerlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannominmerlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannomin
Modification date2018051920180519
UniProtAcc

P35240

P35240

Ensembl transtripts involved in fusion geneENST00000347330, ENST00000413209, 
ENST00000338641, ENST00000403435, 
ENST00000361452, ENST00000403999, 
ENST00000334961, ENST00000353887, 
ENST00000361166, ENST00000397789, 
ENST00000361676, 		ENST00000347330, 
ENST00000413209, ENST00000338641, 
ENST00000403435, ENST00000361452, 
ENST00000403999, ENST00000334961, 
ENST00000353887, ENST00000361166, 
ENST00000397789, ENST00000361676, 
Fusion gene scores* DoF score12 X 7 X 7=5887 X 5 X 6=210
# samples 137
** MAII scorelog2(13/588*10)=-2.17730453180791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NF2 [Title/Abstract] AND NF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF2

GO:0008285

negative regulation of cell proliferation

12444102|20178741

HgeneNF2

GO:0022408

negative regulation of cell-cell adhesion

17210637

HgeneNF2

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

12444102

HgeneNF2

GO:0046426

negative regulation of JAK-STAT cascade

12444102

TgeneNF2

GO:0008285

negative regulation of cell proliferation

12444102|20178741

TgeneNF2

GO:0022408

negative regulation of cell-cell adhesion

17210637

TgeneNF2

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

12444102

TgeneNF2

GO:0046426

negative regulation of JAK-STAT cascade

12444102


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF666966NF2chr22

30091773

+NF2chr22

30092742

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000347330ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000347330ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000347330ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000347330ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000347330ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000413209ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000413209ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000413209ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000413209ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000413209ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000338641ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000338641ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000338641ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000338641ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000338641ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403435ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403435ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403435ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403435ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403435ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000361452ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000361452ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000361452ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-3UTRENST00000361452ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
3UTR-intronENST00000361452ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403999ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403999ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403999ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000403999ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000403999ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000334961ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000334961ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000334961ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000334961ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000334961ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000353887ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000353887ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000353887ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000353887ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000353887ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361166ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361166ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361166ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361166ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361166ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000397789ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000397789ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000397789ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000397789ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000397789ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361676ENST00000347330NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361676ENST00000413209NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361676ENST00000338641NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000403435NF2chr22

30091773

+NF2chr22

30092742

-
intron-3UTRENST00000361676ENST00000361452NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000403999NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000334961NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000353887NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000361166NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000397789NF2chr22

30091773

+NF2chr22

30092742

-
intron-intronENST00000361676ENST00000361676NF2chr22

30091773

+NF2chr22

30092742

-

Top

FusionProtFeatures for NF2_NF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NF2

P35240

NF2

P35240


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NF2_NF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NF2_NF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NF2_NF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NF2_NF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF2C0027832Neurofibromatosis 29CTD_human;ORPHANET;UNIPROT
HgeneNF2C0025500Mesothelioma6CTD_human
HgeneNF2C0345967Malignant mesothelioma4CTD_human
HgeneNF2C0007134Renal Cell Carcinoma1CTD_human
HgeneNF2C0025286Meningioma1CTD_human;HPO
HgeneNF2C0032229Pleural Neoplasms1CTD_human
TgeneNF2C0027832Neurofibromatosis 29CTD_human;ORPHANET;UNIPROT
TgeneNF2C0025500Mesothelioma6CTD_human
TgeneNF2C0345967Malignant mesothelioma4CTD_human
TgeneNF2C0007134Renal Cell Carcinoma1CTD_human
TgeneNF2C0025286Meningioma1CTD_human;HPO
TgeneNF2C0032229Pleural Neoplasms1CTD_human