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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24079

FusionGeneSummary for NEXN_PTGFR

check button Fusion gene summary
Fusion gene informationFusion gene name: NEXN_PTGFR
Fusion gene ID: 24079
HgeneTgene
Gene symbol

NEXN

PTGFR

Gene ID

91624

5737

Gene namenexilin F-actin binding proteinprostaglandin F receptor
SynonymsCMH20|NELINFP
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionnexilinprostaglandin F2-alpha receptorFP prostanoid receptorPGF receptorPGF2 alpha receptorprostaglandin receptor (2-alpha)prostanoid FP receptor
Modification date2018051920180523
UniProtAcc

Q0ZGT2

P43088

Ensembl transtripts involved in fusion geneENST00000457030, ENST00000330010, 
ENST00000294624, ENST00000334785, 
ENST00000480732, 
ENST00000370758, 
ENST00000370756, ENST00000370757, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 2=8
# samples 72
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: NEXN [Title/Abstract] AND PTGFR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEXN

GO:0030334

regulation of cell migration

15823560

TgenePTGFR

GO:0035584

calcium-mediated signaling using intracellular calcium source

18587449


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-3R-A8YX-01ANEXNchr1

78354444

+PTGFRchr1

78958357

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000457030ENST00000370758NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000457030ENST00000370756NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000457030ENST00000370757NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000330010ENST00000370758NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000330010ENST00000370756NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000330010ENST00000370757NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000294624ENST00000370758NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000294624ENST00000370756NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000294624ENST00000370757NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000334785ENST00000370758NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000334785ENST00000370756NEXNchr1

78354444

+PTGFRchr1

78958357

+
5UTR-5UTRENST00000334785ENST00000370757NEXNchr1

78354444

+PTGFRchr1

78958357

+
intron-5UTRENST00000480732ENST00000370758NEXNchr1

78354444

+PTGFRchr1

78958357

+
intron-5UTRENST00000480732ENST00000370756NEXNchr1

78354444

+PTGFRchr1

78958357

+
intron-5UTRENST00000480732ENST00000370757NEXNchr1

78354444

+PTGFRchr1

78958357

+

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FusionProtFeatures for NEXN_PTGFR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEXN

Q0ZGT2

PTGFR

P43088

Receptor for prostaglandin F2-alpha (PGF2-alpha). Theactivity of this receptor is mediated by G proteins which activatea phosphatidylinositol-calcium second messenger system. Initiatesluteolysis in the corpus luteum (By similarity). Isoforms 2 to 7do not bind PGF2-alpha but are proposed to modulate signaling byparticipating in variant receptor complexes; heterodimers betweenisoform 1 and isoform 5 are proposed to be a receptor forprostamides including the synthetic analog bimatoprost.{ECO:0000250, ECO:0000269|PubMed:18587449}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEXN_PTGFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEXN_PTGFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEXNCALM1, CUL1, PAN2, LGR4, HSPB1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, TRIM15, GSN, MYO1B, ACTB, PPP1R9A, ACTA2, ACTBL2, ANK3, ACTR10, CPVL, MYO1D, FBXO34, FBXO46, G3BP1, FAM107A, TESPTGFRPTGFR, NDFIP2, MBOAT7, ATP12A, ATP2B2, ATP2B3, SLC20A2, DNAJC5, ALG6, RHBDD3, NDFIP1, AGTR1, YIPF4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEXN_PTGFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePTGFRP43088DB00287TravoprostProstaglandin F2-alpha receptorsmall moleculeapproved
TgenePTGFRP43088DB08819TafluprostProstaglandin F2-alpha receptorsmall moleculeapproved
TgenePTGFRP43088DB00654LatanoprostProstaglandin F2-alpha receptorsmall moleculeapproved|investigational
TgenePTGFRP43088DB00905BimatoprostProstaglandin F2-alpha receptorsmall moleculeapproved|investigational

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RelatedDiseases for NEXN_PTGFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEXNC2751084Cardiomyopathy, Dilated, 1CC1CTD_human;UNIPROT
HgeneNEXNC3151267CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 201UNIPROT
TgenePTGFRC0001883Airway Obstruction1CTD_human
TgenePTGFRC0014175Endometriosis1CTD_human