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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24078

FusionGeneSummary for NEXN_NEXN

check button Fusion gene summary
Fusion gene informationFusion gene name: NEXN_NEXN
Fusion gene ID: 24078
HgeneTgene
Gene symbol

NEXN

NEXN

Gene ID

91624

91624

Gene namenexilin F-actin binding proteinnexilin F-actin binding protein
SynonymsCMH20|NELINCMH20|NELIN
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionnexilinnexilin
Modification date2018051920180519
UniProtAcc

Q0ZGT2

Q0ZGT2

Ensembl transtripts involved in fusion geneENST00000457030, ENST00000330010, 
ENST00000294624, ENST00000334785, 
ENST00000480732, 		ENST00000457030, 
ENST00000330010, ENST00000294624, 
ENST00000334785, ENST00000480732, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 3 X 2=12
# samples 74
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEXN [Title/Abstract] AND NEXN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEXN

GO:0030334

regulation of cell migration

15823560

TgeneNEXN

GO:0030334

regulation of cell migration

15823560


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW373642NEXNchr1

78392163

-NEXNchr1

78401642

-
ChiTaRS3.1CD299407NEXNchr1

78399146

+NEXNchr1

78395048

+
ChiTaRS3.1AW373769NEXNchr1

78392163

-NEXNchr1

78401642

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000457030ENST00000457030NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000457030ENST00000330010NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000457030ENST00000294624NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000457030ENST00000334785NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-3UTRENST00000457030ENST00000480732NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000330010ENST00000457030NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000330010ENST00000330010NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000330010ENST00000294624NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000330010ENST00000334785NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-3UTRENST00000330010ENST00000480732NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3CDSENST00000294624ENST00000457030NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3CDSENST00000294624ENST00000330010NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-intronENST00000294624ENST00000294624NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-intronENST00000294624ENST00000334785NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3UTRENST00000294624ENST00000480732NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000334785ENST00000457030NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000334785ENST00000330010NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000334785ENST00000294624NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-intronENST00000334785ENST00000334785NEXNchr1

78392163

-NEXNchr1

78401642

-
5CDS-3UTRENST00000334785ENST00000480732NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3CDSENST00000480732ENST00000457030NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3CDSENST00000480732ENST00000330010NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-intronENST00000480732ENST00000294624NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-intronENST00000480732ENST00000334785NEXNchr1

78392163

-NEXNchr1

78401642

-
intron-3UTRENST00000480732ENST00000480732NEXNchr1

78392163

-NEXNchr1

78401642

-
In-frameENST00000457030ENST00000457030NEXNchr1

78399146

+NEXNchr1

78395048

+
In-frameENST00000457030ENST00000330010NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000457030ENST00000294624NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000457030ENST00000334785NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000457030ENST00000480732NEXNchr1

78399146

+NEXNchr1

78395048

+
In-frameENST00000330010ENST00000457030NEXNchr1

78399146

+NEXNchr1

78395048

+
In-frameENST00000330010ENST00000330010NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000330010ENST00000294624NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000330010ENST00000334785NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000330010ENST00000480732NEXNchr1

78399146

+NEXNchr1

78395048

+
intron-3CDSENST00000294624ENST00000457030NEXNchr1

78399146

+NEXNchr1

78395048

+
intron-3CDSENST00000294624ENST00000330010NEXNchr1

78399146

+NEXNchr1

78395048

+
intron-intronENST00000294624ENST00000294624NEXNchr1

78399146

+NEXNchr1

78395048

+
intron-intronENST00000294624ENST00000334785NEXNchr1

78399146

+NEXNchr1

78395048

+
intron-intronENST00000294624ENST00000480732NEXNchr1

78399146

+NEXNchr1

78395048

+
In-frameENST00000334785ENST00000457030NEXNchr1

78399146

+NEXNchr1

78395048

+
In-frameENST00000334785ENST00000330010NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000334785ENST00000294624NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000334785ENST00000334785NEXNchr1

78399146

+NEXNchr1

78395048

+
5CDS-intronENST00000334785ENST00000480732NEXNchr1

78399146

+NEXNchr1

78395048

+
3UTR-3CDSENST00000480732ENST00000457030NEXNchr1

78399146

+NEXNchr1

78395048

+
3UTR-3CDSENST00000480732ENST00000330010NEXNchr1

78399146

+NEXNchr1

78395048

+
3UTR-intronENST00000480732ENST00000294624NEXNchr1

78399146

+NEXNchr1

78395048

+
3UTR-intronENST00000480732ENST00000334785NEXNchr1

78399146

+NEXNchr1

78395048

+
3UTR-intronENST00000480732ENST00000480732NEXNchr1

78399146

+NEXNchr1

78395048

+

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FusionProtFeatures for NEXN_NEXN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEXN

Q0ZGT2

NEXN

Q0ZGT2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEXN_NEXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEXN_NEXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEXN_NEXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEXN_NEXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEXNC2751084Cardiomyopathy, Dilated, 1CC1CTD_human;UNIPROT
HgeneNEXNC3151267CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 201UNIPROT
TgeneNEXNC2751084Cardiomyopathy, Dilated, 1CC1CTD_human;UNIPROT
TgeneNEXNC3151267CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 201UNIPROT