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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24064

FusionGeneSummary for NEU3_POLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEU3_POLA2
Fusion gene ID: 24064
HgeneTgene
Gene symbol

NEU3

POLA2

Gene ID

10825

23649

Gene nameneuraminidase 3DNA polymerase alpha 2, accessory subunit
SynonymsSIAL3-
Cytomap

11q13.4

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionsialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidasemembrane sialidasesialidase 3 (membrane sialidase)DNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2018052320180523
UniProtAcc

Q9UQ49

Q14181

Ensembl transtripts involved in fusion geneENST00000294064, ENST00000531509, 
ENST00000544263, ENST00000529024, 
ENST00000532963, ENST00000531619, 
ENST00000545272, ENST00000526068, 
ENST00000534628, 
ENST00000265465, 
ENST00000541089, ENST00000534785, 
Fusion gene scores* DoF score3 X 3 X 1=97 X 6 X 5=210
# samples 47
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEU3 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEU3

GO:0005975

carbohydrate metabolic process

12730204

HgeneNEU3

GO:0006689

ganglioside catabolic process

10861246

HgeneNEU3

GO:0009313

oligosaccharide catabolic process

10861246


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-LL-A6FQ-01ANEU3chr11

74705765

+POLA2chr11

65043363

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000294064ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000294064ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000294064ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000531509ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531509ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000531509ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000544263ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000544263ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000544263ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000529024ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000529024ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000529024ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000532963ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000532963ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000532963ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
In-frameENST00000531619ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000531619ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000531619ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000545272ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000545272ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000545272ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-3CDSENST00000526068ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-5UTRENST00000526068ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
intron-intronENST00000526068ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+
Frame-shitENST00000534628ENST00000265465NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-5UTRENST00000534628ENST00000541089NEU3chr11

74705765

+POLA2chr11

65043363

+
5CDS-intronENST00000534628ENST00000534785NEU3chr11

74705765

+POLA2chr11

65043363

+

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FusionProtFeatures for NEU3_POLA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEU3

Q9UQ49

POLA2

Q14181

Plays a role in modulating the ganglioside content ofthe lipid bilayer at the level of membrane-bound sialylglycoconjugates. {ECO:0000269|PubMed:10861246,ECO:0000269|PubMed:20511247}. May play an essential role at the early stage ofchromosomal DNA replication by coupling the polymerasealpha/primase complex to the cellular replication machinery.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+3424_2769429MotifNote=FRIP motif
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465+318115_157118599Compositional biasNote=Pro/Ser/Thr-rich
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465+318486_489118599Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34129_14069429RepeatNote=BNR 1
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34203_21469429RepeatNote=BNR 2
HgeneNEU3chr11:74705765chr11:65043363ENST00000544263+34254_26569429RepeatNote=BNR 3
TgenePOLA2chr11:74705765chr11:65043363ENST00000265465+318101_107118599Compositional biasNote=Poly-Glu


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FusionGeneSequence for NEU3_POLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEU3_ENST00000294064_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_583aa
MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLV
LRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVL
GCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPV
DLSELKETSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFTQPTEEDADFEQSMVLVACGPYTTSDSITTDPLLDLIAVINHDRPDVCI
LFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSING
VIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDTESFTVYAQLPVTPDVLIIPSELRYFVKDVLGCVC

>In-frame_NEU3_ENST00000531509_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_583aa
MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLV
LRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVL
GCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPV
DLSELKETSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFTQPTEEDADFEQSMVLVACGPYTTSDSITTDPLLDLIAVINHDRPDVCI
LFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSING
VIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDTESFTVYAQLPVTPDVLIIPSELRYFVKDVLGCVC

>In-frame_NEU3_ENST00000544263_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_550aa
MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVST
RSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGS
ELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKETSLFPGQVVIMEGINTTGRKLVATKL
YEGVPLPFTQPTEEDADFEQSMVLVACGPYTTSDSITTDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTI
IEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRIL
KHILTQRSYYPLYPPQEDMAIDTESFTVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSP

>In-frame_NEU3_ENST00000531619_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_583aa
MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLV
LRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVL
GCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPV
DLSELKETSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFTQPTEEDADFEQSMVLVACGPYTTSDSITTDPLLDLIAVINHDRPDVCI
LFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSING
VIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDTESFTVYAQLPVTPDVLIIPSELRYFVKDVLGCVC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEU3_ENST00000294064_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_1749nt
ATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGT
GCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCA
GCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTG
CTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGT
GTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAAC
CGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTG
GGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAA
CTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAG
ATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTG
GATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCC
ACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGT
GGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATC
CTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTA
CGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCC
CAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGA
GTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGC
CGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTAT
GTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGT
GTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGG

>In-frame_NEU3_ENST00000531509_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_1749nt
ATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGT
GCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCA
GCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTG
CTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGT
GTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAAC
CGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTG
GGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAA
CTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAG
ATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTG
GATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCC
ACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGT
GGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATC
CTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTA
CGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCC
CAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGA
GTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGC
CGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTAT
GTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGT
GTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGG

>In-frame_NEU3_ENST00000544263_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_1650nt
ATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTC
TACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGA
GGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACT
CGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAA
GTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCA
GAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGC
GAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGT
GATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCT
GAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTC
TACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATAC
ACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGC
CCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATT
ATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCT
TTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTC
GGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTC
AAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCA
CAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCT
GGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCA

>In-frame_NEU3_ENST00000531619_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_1749nt
ATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGT
GCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCA
GCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTG
CTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGT
GTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAAC
CGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTG
GGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAA
CTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAG
ATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTG
GATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCC
ACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGT
GGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATC
CTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTA
CGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCC
CAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGA
GTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGC
CGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTAT
GTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGT
GTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEU3_ENST00000294064_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_4092nt
TTTCCTTTTATTGGCGTTTGTAAAATTTCTTCTTTTTAAAATTGTTATATTTTAGAGACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTG
CAGTGGTGCAATCACAGCTCACCACAGCCTCCAACTCCTGGGCTCAAGGCATCCTCCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGG
CATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAAAAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTG
GGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCTATGTGACAAATCTATGTATGTAAATGTGTGTATAT
ACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGAGAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTG
TAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAAGCTTTAGGCGGTGATACCGAGCTACAGACCAATAT
AAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGGTGGGCCCAGGGCTTGAGCTGAGTTGGCGAGGGTGGAG
GTGGTGCCGGTCCCACGCCGTGGTGGGGACCGAGCTGCGGGCTGGAGGGAGGGGCAGCGCCGAGGGGGCGGGACGGGGAGGGCTCGCGGA
GTAGGCCAACGGTTGGCCCCAACCGCCACTGACTACAGCCTGCGCCCGCCTCTTTTCGTTGCCGTTACCTGTTTCCGGCAGTCGACACGC
TCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGGG
GCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCG
ACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGAT
GACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGG
AGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACC
CCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCC
TCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGA
GCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGA
GAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCA
CAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAA
CATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATC
AACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTT
GAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATC
AACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCA
TTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGA
GATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCC
GAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGT
TCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGAC
ATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTC
GTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGG
AGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCT
GCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAG
CCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAG
CTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTT
CTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATT
TATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCC
GGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAG
TGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATT
ACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCA
GAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAA
GGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTC
CCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAG
TCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTT
CACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAG
GCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGT
CTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCCA

>In-frame_NEU3_ENST00000531509_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_3655nt
CCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGGCATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAA
AAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTGGGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCT
ATGTGACAAATCTATGTATGTAAATGTGTGTATATACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGA
GAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTGTAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAA
GCTTTAGGCGGTGATACCGAGCTACAGACCAATATAAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGTCT
CCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTC
CAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTT
CCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAA
GCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCG
AGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCC
AAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTC
TGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCT
CCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTT
GCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGA
GGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAAT
TATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGA
GGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCT
GATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCT
ACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGT
CCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGT
ACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGA
GGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCC
GCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGA
GCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCG
ACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCC
TCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGG
AGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTC
TCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAG
GCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCT
ATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCA
AGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTT
TTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATT
TGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTC
CTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGC
ATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGT
TCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAG
GCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGC
CCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGC
AAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATG

>In-frame_NEU3_ENST00000544263_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_3236nt
AGAGAGGAGGCGGCCGTTGGGAACTGAGTCTCCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGC
CCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAG
TGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCC
CCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGA
TTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCC
ATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCT
CCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAA
CTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGG
AACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACG
GGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGG
AATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTG
TGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTG
ACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGG
ATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCA
CAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACT
CCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACAT
CCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCT
TGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTG
TCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTA
CCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTG
TGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCC
TGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTG
TGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTG
TGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCT
GAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTG
GAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCT
GACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTA
TCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGT
CCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTA
GAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCT
CCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTG
CCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCT
GTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCT
GTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAAC

>In-frame_NEU3_ENST00000531619_chr11_74705765_+_POLA2_ENST00000265465_chr11_65043363_+_3283nt
CTCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGG
GGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCC
GACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGA
TGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAG
GAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTAC
CCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCC
CTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGG
AGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCG
AGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGC
ACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGA
ACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAAT
CAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTT
TGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCAT
CAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCC
ATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAG
AGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTC
CGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAG
TTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGA
CATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTT
CGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAG
GAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTC
TGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCA
GCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAA
GCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTT
TCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTAT
TTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCC
CGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTA
GTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCC
AGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAA
AGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCT
CCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGA
GTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGT
TCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCA
GGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTG
TCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCC


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FusionGenePPI for NEU3_POLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEU3GRB2, CAV1, KLK11, KLK5, PLA2G10, ALOX5POLA2FAM219A, DHX34, IGFBP3, STK40, ULK2, XPNPEP1, KLF6, CPE, CRELD1, FGFR3, PRPF38A, HGH1, LRPAP1, NHP2L1, SETDB1, RBM23, ASCC2, ATP5C1, DDX24, EZH2, AKTIP, EIF6, POLA1, PARP1, HELB, RAE1, KCNE3, HDAC6, NR4A1, FRZB, APP, PRIM1, PRIM2, MMS19, DCP2, EPB41L1, HEXIM1, UBE2O, POP7, REPIN1, CIAO1, POLD2, SCYL1, XPO1, CAPN1, POU5F1, RAC1, TKT, LGALS7, SNX21, ZBBX, LRRC27, ARPC5, SSH3, OBFC1, LIPH, MPZL1, TULP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEU3_POLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePOLA2Q14181DB00851DacarbazineDNA polymerase alpha subunit Bsmall moleculeapproved|investigational

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RelatedDiseases for NEU3_POLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource