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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24063

FusionGeneSummary for NEU3_NDUFV1

check button Fusion gene summary
Fusion gene informationFusion gene name: NEU3_NDUFV1
Fusion gene ID: 24063
HgeneTgene
Gene symbol

NEU3

NDUFV1

Gene ID

10825

4723

Gene nameneuraminidase 3NADH:ubiquinone oxidoreductase core subunit V1
SynonymsSIAL3CI-51K|CI51KD|UQOR1
Cytomap

11q13.4

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionsialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidasemembrane sialidasesialidase 3 (membrane sialidase)NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainm
Modification date2018052320180523
UniProtAcc

Q9UQ49

P49821

Ensembl transtripts involved in fusion geneENST00000294064, ENST00000531509, 
ENST00000544263, ENST00000529024, 
ENST00000532963, ENST00000531619, 
ENST00000545272, ENST00000526068, 
ENST00000534628, 
ENST00000322776, 
ENST00000532303, ENST00000529927, 
ENST00000415352, ENST00000526169, 
Fusion gene scores* DoF score3 X 3 X 1=935 X 6 X 14=2940
# samples 437
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(37/2940*10)=-2.99021897920741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEU3 [Title/Abstract] AND NDUFV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEU3

GO:0005975

carbohydrate metabolic process

12730204

HgeneNEU3

GO:0006689

ganglioside catabolic process

10861246

HgeneNEU3

GO:0009313

oligosaccharide catabolic process

10861246


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AC-A3OD-01BNEU3chr11

74700199

+NDUFV1chr11

67375867

+
TCGALDBRCATCGA-AC-A3OD-01ANEU3chr11

74700199

+NDUFV1chr11

67375871

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000294064ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000294064ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000294064ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000294064ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000294064ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000531509ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531509ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531509ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531509ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531509ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-3CDSENST00000544263ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000544263ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000544263ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000544263ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000544263ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000529024ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000529024ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000529024ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000529024ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000529024ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000532963ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000532963ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000532963ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000532963ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000532963ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000531619ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531619ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531619ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531619ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000531619ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-3CDSENST00000545272ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000545272ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000545272ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000545272ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5UTR-intronENST00000545272ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000526068ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000526068ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000526068ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000526068ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000526068ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000534628ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000534628ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000534628ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000534628ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375867

+
5CDS-intronENST00000534628ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375867

+
Frame-shitENST00000294064ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000294064ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000294064ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000294064ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000294064ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000531509ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531509ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531509ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531509ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531509ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-3CDSENST00000544263ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000544263ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000544263ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000544263ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000544263ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000529024ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000529024ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000529024ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000529024ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000529024ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000532963ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000532963ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000532963ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000532963ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000532963ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000531619ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531619ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531619ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531619ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000531619ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-3CDSENST00000545272ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000545272ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000545272ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000545272ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5UTR-intronENST00000545272ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000526068ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000526068ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000526068ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000526068ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000526068ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+
Frame-shitENST00000534628ENST00000322776NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000534628ENST00000532303NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000534628ENST00000529927NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000534628ENST00000415352NEU3chr11

74700199

+NDUFV1chr11

67375871

+
5CDS-intronENST00000534628ENST00000526169NEU3chr11

74700199

+NDUFV1chr11

67375871

+

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FusionProtFeatures for NEU3_NDUFV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEU3

Q9UQ49

NDUFV1

P49821

Plays a role in modulating the ganglioside content ofthe lipid bilayer at the level of membrane-bound sialylglycoconjugates. {ECO:0000269|PubMed:10861246,ECO:0000269|PubMed:20511247}. Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEU3_NDUFV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEU3_NDUFV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEU3GRB2, CAV1, KLK11, KLK5, PLA2G10, ALOX5NDUFV1EWSR1, ICT1, COPS5, NDUFS8, NDUFS3, NDUFS7, NDUFS2, NDUFV2, NDUFS1, NDUFA9, NDUFB6, NDUFB10, TCOF1, VPS29, TMEM189, RRM1, NOTCH2, STMN1, TIMM9, HNRNPR, PNP, ABCD3, MPST, TOR1AIP1, ILF3, ERGIC1, DNAJB11, CPT1A, HTRA2, PAICS, HSPA1L, PALLD, SDHA, RNASET2, ADRB2, NDUFA8, COX5A, EEF2, MRPL45, ANXA11, ATP1A1, ATP1B1, ATP5F1, ATP6V0D1, FH, MTCH1, NDUFA10, NDUFA2, NDUFB8, NDUFS4, POR, SLC9A3R2, TOMM40, TPI1, UQCRB, VDAC2, PDHA1, PHB2, PSMD7, SDHB, STXBP1, UQCRFS1, NPHP1, NDUFA12, NDUFS5, NDUFA11, NDUFA13, NDUFS6, OXCT1, NDUFV3, ND1, ND5, NDUFB4, TIMMDC1, VAPA, GOLT1B, FOXQ1, NDUFA4, C15orf48, OCIAD1, COQ2, PAK7, COX6B1, C7orf55, C6orf203, COA3, NDUFB11, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NEU3_NDUFV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NEU3_NDUFV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNDUFV1C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY2CTD_human;UNIPROT
TgeneNDUFV1C0005586Bipolar Disorder1PSYGENET
TgeneNDUFV1C0023264Leigh Disease1CTD_human;ORPHANET;UNIPROT
TgeneNDUFV1C0029408Degenerative polyarthritis1CTD_human
TgeneNDUFV1C0036341Schizophrenia1PSYGENET
TgeneNDUFV1C0038356Stomach Neoplasms1CTD_human
TgeneNDUFV1C0041696Unipolar Depression1PSYGENET
TgeneNDUFV1C1269683Major Depressive Disorder1PSYGENET