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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24027

FusionGeneSummary for NELFCD_NELFCD

check button Fusion gene summary
Fusion gene informationFusion gene name: NELFCD_NELFCD
Fusion gene ID: 24027
HgeneTgene
Gene symbol

NELFCD

NELFCD

Gene ID

51497

51497

Gene namenegative elongation factor complex member C/Dnegative elongation factor complex member C/D
SynonymsHSPC130|NELF-C|NELF-D|TH1|TH1LHSPC130|NELF-C|NELF-D|TH1|TH1L
Cytomap

20q13.32

20q13.32

Type of geneprotein-codingprotein-coding
Descriptionnegative elongation factor C/DNELF-C/DTH1 drosophila homologTH1-like proteinnegative elongation factor proteins C and Dtrihydrophobin 1negative elongation factor C/DNELF-C/DTH1 drosophila homologTH1-like proteinnegative elongation factor proteins C and Dtrihydrophobin 1
Modification date2018052220180522
UniProtAcc

Q8IXH7

Q8IXH7

Ensembl transtripts involved in fusion geneENST00000602795, ENST00000344018, 
ENST00000479207, 
ENST00000602795, 
ENST00000344018, ENST00000479207, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: NELFCD [Title/Abstract] AND NELFCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW995203NELFCDchr20

57556346

-NELFCDchr20

57561145

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000602795ENST00000602795NELFCDchr20

57556346

-NELFCDchr20

57561145

+
In-frameENST00000602795ENST00000344018NELFCDchr20

57556346

-NELFCDchr20

57561145

+
5CDS-intronENST00000602795ENST00000479207NELFCDchr20

57556346

-NELFCDchr20

57561145

+
In-frameENST00000344018ENST00000602795NELFCDchr20

57556346

-NELFCDchr20

57561145

+
In-frameENST00000344018ENST00000344018NELFCDchr20

57556346

-NELFCDchr20

57561145

+
5CDS-intronENST00000344018ENST00000479207NELFCDchr20

57556346

-NELFCDchr20

57561145

+
intron-3CDSENST00000479207ENST00000602795NELFCDchr20

57556346

-NELFCDchr20

57561145

+
intron-3CDSENST00000479207ENST00000344018NELFCDchr20

57556346

-NELFCDchr20

57561145

+
intron-intronENST00000479207ENST00000479207NELFCDchr20

57556346

-NELFCDchr20

57561145

+

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FusionProtFeatures for NELFCD_NELFCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NELFCD

Q8IXH7

NELFCD

Q8IXH7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NELFCD_NELFCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NELFCD_NELFCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NELFCD_NELFCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NELFCD_NELFCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource