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Fusion gene ID: 24025 |
FusionGeneSummary for NELFB_FBXW5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NELFB_FBXW5 | Fusion gene ID: 24025 | Hgene | Tgene | Gene symbol | NELFB | FBXW5 | Gene ID | 25920 | 54461 |
| Gene name | negative elongation factor complex member B | F-box and WD repeat domain containing 5 | |
| Synonyms | COBRA1|NELF-B | Fbw5 | |
| Cytomap | 9q34.3 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | negative elongation factor Bcofactor of BRCA1negative elongation factor protein B | F-box/WD repeat-containing protein 5F-box and WD-40 domain-containing protein 5WD repeat-containing F-box protein FBW5 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8WX92 | Q969U6 | |
| Ensembl transtripts involved in fusion gene | ENST00000343053, | ENST00000325285, ENST00000483559, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NELFB [Title/Abstract] AND FBXW5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXW5 | GO:0016567 | protein ubiquitination | 18381890|21725316 |
| Tgene | FBXW5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 21725316 |
| Tgene | FBXW5 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 18381890 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-JY-A6FH-01A | NELFB | chr9 | 140161798 | + | FBXW5 | chr9 | 139836136 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000343053 | ENST00000325285 | NELFB | chr9 | 140161798 | + | FBXW5 | chr9 | 139836136 | - |
| 5CDS-5UTR | ENST00000343053 | ENST00000483559 | NELFB | chr9 | 140161798 | + | FBXW5 | chr9 | 139836136 | - |
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FusionProtFeatures for NELFB_FBXW5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NELFB | FBXW5 |
| Essential component of the NELF complex, a complex thatnegatively regulates the elongation of transcription by RNApolymerase II. The NELF complex, which acts via an associationwith the DSIF complex and causes transcriptional pausing, iscounteracted by the P-TEFb kinase complex. The NELF complex isinvolved in HIV-1 latency possibly involving recruitment of PCF11to paused RNA polymerase II. Binds RNA which may help to stabilizethe NELF complex on nucleic acid. In vitro, binds weakly to theHIV-1 TAR RNA which is located in the long terminal repeat (LTR)of HIV-1. May be able to induce chromatin unfolding.{ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062,ECO:0000269|PubMed:23884411, ECO:0000269|PubMed:27282391}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 394_447 | 365 | 567 | Repeat | Note=WD 5 |
| Tgene | >FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 458_501 | 365 | 567 | Repeat | Note=WD 6 |
| Tgene | >FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 502_539 | 365 | 567 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 3_49 | 365 | 567 | Domain | F-box |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 303_311 | 365 | 567 | Motif | Note=D-box |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 126_178 | 365 | 567 | Repeat | Note=WD 2 |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 179_238 | 365 | 567 | Repeat | Note=WD 3 |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 239_281 | 365 | 567 | Repeat | Note=WD 4 |
| Tgene | FBXW5 | chr9:140161798 | chr9:139836136 | ENST00000325285 | - | 5 | 9 | 83_125 | 365 | 567 | Repeat | Note=WD 1 |
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FusionGeneSequence for NELFB_FBXW5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NELFB_ENST00000343053_chr9_140161798_+_FBXW5_ENST00000325285_chr9_139836136_-_650aa MFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERY KKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTE LSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCHKFTWCLDACI RERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVF KEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLGI KQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDIHGHIIGMGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVR RALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NELFB_ENST00000343053_chr9_140161798_+_FBXW5_ENST00000325285_chr9_139836136_-_1950nt ATGTTCGCGGGGCTGCAGGACCTGGGCGTGGCCAACGGCGAGGACCTGAAGGAGACCCTGACCAACTGCACGGAGCCGCTCAAGGCCATC GAGCAGTTCCAGACAGAGAATGGTGTGCTGCTGCCATCTCTTCAGTCAGCCCTCCCCTTCTTGGACCTGCACGGGACGCCGCGGCTGGAG TTCCACCAGTCGGTATTCGATGAGCTGCGGGACAAGCTGCTGGAGCGAGTGTCAGCCATCGCTTCGGAGGGGAAGGCTGAGGAAAGGTAC AAGAAGCTGGAAGACCTTCTGGAGAAGAGCTTTTCTCTGGTGAAGATGCCGTCCCTGCAGCCCGTGGTGATGTGCGTCATGAAGCACCTG CCCAAGGTTCCGGAGAAAAAACTGAAGCTGGTTATGGCTGACAAGGAGCTGTATCGAGCCTGCGCCGTGGAGGTGAAGCGGCAGATCTGG CAAGACAACCAGGCCCTCTTCGGGGACGAGGTTTCCCCACTCCTGAAGCAGTACATCCTGGAGAAGGAGAGCGCTCTCTTCAGTACAGAG CTCTCTGTCCTGCACAACTTTTTCAGTCCTTCCCCCAAGACCAGGCGCCAGGGCGAGGTGGTGCAGCGGCTGACGCGGATGGTGGGGAAG AACGTGAAGCTGTACGACATGGTGCTGCAGTTTCTGCGCACGCTCTTCCTGCGCACGCGGAATGTGCACTACTGCACGCTGCGGGCTGAG CTGCTCATGTCCCTGCACGACCTGGACGTGGGTGAAATCTGCACCGTGGACCCGTGCCACAAGTTCACCTGGTGCCTGGACGCCTGCATC CGAGAGCGGTTCGTGGACAGCAAGAGGGCGCGGGAGCTGCAGGGGTTTCTCGATGGCGTCAAGAAGGGCCAGGAGCAGGTGCTGGGGGAC CTGTCCATGATCCTGTGTGACCCCTTCGCCATCAACACGCTGGCACTGAGCACAGTCAGGCACCTGCAGGAGCTGGTCGGCCAGGAGACA CTGCCCAGGGACAGCCCCGACCTCCTGCTGCTGCTCCGGCTGCTGGCGCTGGGCCAGGGAGCCTGGGACATGATCGACAGCCAGGTCTTC AAGGAGCCCAAGATGGAGGTAGAGCTCATCACCAGGTTCCTCCCGATGCTCATGTCCTTCCTGGTGGATGACTACACTTTCAATGTGGAT CAGAAACTTCCGGCTGAGGAGAAAGCCCCAGTCTCATATCCAAACACACTTCCCGAAAGCTTCACTAAGTTTCTGCAGGAGCAGCGCATG GCCTGCGAGGTGGGGCTGTACTACGTCCTGCACATCACCAAGCAGAGGAACAAGAACGCGCTCCTCCGCCTGCTGCCCGGGCTGGGCATC AAGCAGATCCTGCCACACCAGATGACCACGGCAGGGCCCGTGCTGGGTGAGGGCCGGGGCTCCGATGCCTTCTTCGACGCGCTGGACCAC GTCATAGACATACACGGACACATCATCGGCATGGGCCTGTCGCCCGACAACAGGTACCTGTACGTGAACAGCCGCGCCTGGCCCAACGGT GCGGTGGTGGCCGACCCCATGCAGCCGCCACCAATCGCGGAGGAGATTGACCTGCTGGTGTTCGACCTCAAGACCATGCGGGAGGTGAGG CGGGCTCTGCGTGCGCACCGCGCCTACACGCCCAACGACGAGTGCTTCTTCATCTTCCTGGACGTCAGCAGGGACTTCGTGGCCAGCGGG GCGGAGGACCGGCACGGCTACATCTGGGACCGCCACTACAACATCTGTCTGGCCAGGCTGCGGCACGAGGATGTGGTCAACTCAGTGGTC TTCAGTCCCCAGGAGCAGGAGCTGCTGCTCACGGCCAGCGACGACGCCACCATCAAAGCCTGGCGCTCCCCACGCACCATGCGCGTCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NELFB_ENST00000343053_chr9_140161798_+_FBXW5_ENST00000325285_chr9_139836136_-_2780nt CGGGACCGGGTGGGCGCATGCGCGCTGGGCTGGCTGGGCGGGGTCTCTCGCGCCGGGTGAGGGCGCTGCTCCCAGGAACCTGCGCGCGGC CCCGGCGGCGTTTCCCGGGGGCCGGTTGGCGGGCGGACCTGGGCGGTGCGGGGCGGAAGTGGGCGGCTGCGGGACGCGCGCGGAGTCGCG CGGCGGGCGGGACCTGGCCGAGCTGGAGGGCGCCGGGGAGCGGGGCTCGGGCGGTCCCCGAGGCCCGGCGGAGCGGGCTTCTGGGGTGTC TGCGGCGGCGCCGGGGGAACGGGCTGGGGATGGGGCGCCTAGCCGGGCGGTGGCCGGGGCCTCGGCCATGTTCGCGGGGCTGCAGGACCT GGGCGTGGCCAACGGCGAGGACCTGAAGGAGACCCTGACCAACTGCACGGAGCCGCTCAAGGCCATCGAGCAGTTCCAGACAGAGAATGG TGTGCTGCTGCCATCTCTTCAGTCAGCCCTCCCCTTCTTGGACCTGCACGGGACGCCGCGGCTGGAGTTCCACCAGTCGGTATTCGATGA GCTGCGGGACAAGCTGCTGGAGCGAGTGTCAGCCATCGCTTCGGAGGGGAAGGCTGAGGAAAGGTACAAGAAGCTGGAAGACCTTCTGGA GAAGAGCTTTTCTCTGGTGAAGATGCCGTCCCTGCAGCCCGTGGTGATGTGCGTCATGAAGCACCTGCCCAAGGTTCCGGAGAAAAAACT GAAGCTGGTTATGGCTGACAAGGAGCTGTATCGAGCCTGCGCCGTGGAGGTGAAGCGGCAGATCTGGCAAGACAACCAGGCCCTCTTCGG GGACGAGGTTTCCCCACTCCTGAAGCAGTACATCCTGGAGAAGGAGAGCGCTCTCTTCAGTACAGAGCTCTCTGTCCTGCACAACTTTTT CAGTCCTTCCCCCAAGACCAGGCGCCAGGGCGAGGTGGTGCAGCGGCTGACGCGGATGGTGGGGAAGAACGTGAAGCTGTACGACATGGT GCTGCAGTTTCTGCGCACGCTCTTCCTGCGCACGCGGAATGTGCACTACTGCACGCTGCGGGCTGAGCTGCTCATGTCCCTGCACGACCT GGACGTGGGTGAAATCTGCACCGTGGACCCGTGCCACAAGTTCACCTGGTGCCTGGACGCCTGCATCCGAGAGCGGTTCGTGGACAGCAA GAGGGCGCGGGAGCTGCAGGGGTTTCTCGATGGCGTCAAGAAGGGCCAGGAGCAGGTGCTGGGGGACCTGTCCATGATCCTGTGTGACCC CTTCGCCATCAACACGCTGGCACTGAGCACAGTCAGGCACCTGCAGGAGCTGGTCGGCCAGGAGACACTGCCCAGGGACAGCCCCGACCT CCTGCTGCTGCTCCGGCTGCTGGCGCTGGGCCAGGGAGCCTGGGACATGATCGACAGCCAGGTCTTCAAGGAGCCCAAGATGGAGGTAGA GCTCATCACCAGGTTCCTCCCGATGCTCATGTCCTTCCTGGTGGATGACTACACTTTCAATGTGGATCAGAAACTTCCGGCTGAGGAGAA AGCCCCAGTCTCATATCCAAACACACTTCCCGAAAGCTTCACTAAGTTTCTGCAGGAGCAGCGCATGGCCTGCGAGGTGGGGCTGTACTA CGTCCTGCACATCACCAAGCAGAGGAACAAGAACGCGCTCCTCCGCCTGCTGCCCGGGCTGGGCATCAAGCAGATCCTGCCACACCAGAT GACCACGGCAGGGCCCGTGCTGGGTGAGGGCCGGGGCTCCGATGCCTTCTTCGACGCGCTGGACCACGTCATAGACATACACGGACACAT CATCGGCATGGGCCTGTCGCCCGACAACAGGTACCTGTACGTGAACAGCCGCGCCTGGCCCAACGGTGCGGTGGTGGCCGACCCCATGCA GCCGCCACCAATCGCGGAGGAGATTGACCTGCTGGTGTTCGACCTCAAGACCATGCGGGAGGTGAGGCGGGCTCTGCGTGCGCACCGCGC CTACACGCCCAACGACGAGTGCTTCTTCATCTTCCTGGACGTCAGCAGGGACTTCGTGGCCAGCGGGGCGGAGGACCGGCACGGCTACAT CTGGGACCGCCACTACAACATCTGTCTGGCCAGGCTGCGGCACGAGGATGTGGTCAACTCAGTGGTCTTCAGTCCCCAGGAGCAGGAGCT GCTGCTCACGGCCAGCGACGACGCCACCATCAAAGCCTGGCGCTCCCCACGCACCATGCGCGTCCTCCAGGCACCTCGCCCACGGCCTCG CACCTTCTTCTCCTGGCTTGCCAGCCAGAGGCGCTGAGGTGTGCTGGGTGCACTGGAGCCACCGGGACCCCTTGAGGACATCGCCAGGCT CTGTGGCTTTTTCCCGAGCGGGAGAGGTGGAGATGCTTATAGCAGTTACGCCTTAGGAAGGGGACAACCAGGCCCCGCCACACGCTCACA CACAAACCTGCTCACGCAGCTGTGATGCTTGGCACGGGGTGGCCAGTGCAGATGGAGCCCAAGGCCCCCTCGGCCTCCTGGGCAACTTGG GGTACACAGGATACTGGGGGTGCCGCTCCTCACTCAACCCCAGGCTAGGGGTACACCTGACCCAGCTGGCCTCGGCCCGGGGCACCTTCG GCTGGTCCTGTGGGGCCCTGGACGGTGGCCCAGTGGTGGCAGGGGCTGCTCCTGGCTGTGGTTGTGCGCCCGGGGCTTGGGAGCGGCCGG |
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FusionGenePPI for NELFB_FBXW5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NELFB | NELFE, JUN, FOS, NELFCD, BRCA1, ESR1, NELFA, CEBPE, MAPK6, ALDH3A2, ATP1A1, CCT8, MSH2, RPN1, NELFB, SUPT5H, POLR2A, POLR2C, HSPA9, KHDRBS3, MGST1, DENR, YWHAB, ABCF1, YBX3, DDX1, DHX9, DIMT1, EDC4, EIF2B2, EIF2B3, EIF3C, FKBP3, PA2G4, HNRNPU, IGF2BP3, ILF2, MRE11A, NMT1, PTBP1, RFC4, RPL23A, SYNCRIP, YBX1, ELP6, NTRK1, RAD51, NCBP1, FECH, ANK1 | FBXW5 | KRTAP4-12, MDFI, NLK, DDB1, CUL4A, TSC1, TSC2, WDR20, CDC20, SASS6, PLK4, UBE2R2, SKP1, REST, CUL1, MYB, MAP3K7, HSP90AA1, DLC1, TNFAIP8L1, CUL3, KRT31, TRIM27, ADAMTSL4, KRTAP9-4, KRT40, KRTAP10-8, KRTAP10-3, NOTCH2NL, ODF3L2, SRFBP1, ZNRF1, HSPB9, FAM168A, S100B, XPO1, FOXR1, DEFB1, NDEL1, NEFM, TSNAXIP1, ZNF704 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NELFB_FBXW5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NELFB_FBXW5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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