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Fusion gene ID: 24010 |
FusionGeneSummary for NEK6_RASEF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEK6_RASEF | Fusion gene ID: 24010 | Hgene | Tgene | Gene symbol | NEK6 | RASEF | Gene ID | 10783 | 158158 |
| Gene name | NIMA related kinase 6 | RAS and EF-hand domain containing | |
| Synonyms | SID6-1512 | RAB45 | |
| Cytomap | 9q33.3 | 9q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Nek6NIMA (never in mitosis gene a)-related kinase 6never in mitosis A-related kinase 6nimA-related protein kinase 6protein kinase SID6-1512putative serine-threonine protein kinase | ras and EF-hand domain-containing proteinras-related protein Rab-45 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9HC98 | Q8IZ41 | |
| Ensembl transtripts involved in fusion gene | ENST00000540326, ENST00000373603, ENST00000373600, ENST00000320246, ENST00000545174, ENST00000394199, ENST00000546191, ENST00000539416, | ENST00000376447, ENST00000340717, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 3=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEK6 [Title/Abstract] AND RASEF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEK6 | GO:0006468 | protein phosphorylation | 12840024 |
| Hgene | NEK6 | GO:0007059 | chromosome segregation | 14563848 |
| Hgene | NEK6 | GO:0018105 | peptidyl-serine phosphorylation | 19001501 |
| Hgene | NEK6 | GO:0030071 | regulation of mitotic metaphase/anaphase transition | 14563848 |
| Hgene | NEK6 | GO:0046777 | protein autophosphorylation | 14563848|20873783 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AY-A71X-01A | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000540326 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000540326 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-3CDS | ENST00000373603 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000373603 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| 5UTR-3CDS | ENST00000373600 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| 5UTR-intron | ENST00000373600 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| 5UTR-3CDS | ENST00000320246 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| 5UTR-intron | ENST00000320246 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-3CDS | ENST00000545174 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000545174 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-3CDS | ENST00000394199 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000394199 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-3CDS | ENST00000546191 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000546191 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-3CDS | ENST00000539416 | ENST00000376447 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
| intron-intron | ENST00000539416 | ENST00000340717 | NEK6 | chr9 | 127020364 | + | RASEF | chr9 | 85616045 | - |
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FusionProtFeatures for NEK6_RASEF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK6 | RASEF |
| Protein kinase which plays an important role in mitoticcell cycle progression. Required for chromosome segregation atmetaphase-anaphase transition, robust mitotic spindle formationand cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6,RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. PhosphorylatesKIF11 to promote mitotic spindle formation. Involved in G2/M phasecell cycle arrest induced by DNA damage. Inhibition of activityresults in apoptosis. May contribute to tumorigenesis bysuppressing p53/TP53-induced cancer cell senescence.{ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848,ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501,ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20407017,ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361}. | Binds predominantly GDP, and also GTP.{ECO:0000269|PubMed:17448446}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEK6_RASEF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEK6_RASEF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEK6 | CCDC85B, NECAB2, NEK9, EML3, USP9X, CCAR2, IPO4, NEK7, LRPPRC, SMC3, MCM7, EML2, DYNLL1, SLC1A5, NUP93, XPO5, PTPLAD1, FANCI, GCN1L1, PCID2, EML4, KDELR1, CDC37, RUVBL2, PSMD2, MYO1C, DERA, PAK6, ARRB1, KCTD5, PHF1, PRDX3, PRAM1, PTN, RBBP6, ARHGAP33, TRIP4, RPS7, RELB, CIR1, CDC42, ERCC6L2, ATF4, ANKRA2, NEK6, AES, XIAP, TRIM23, KRT31, TRIM27, TCF4, TNK2, IKZF1, IKZF3, HSD17B14, FAM208B, LZTS2, LNX1, KRT40, CCDC36, INCA1, NFATC1, LAMP3, IL13RA2, LAMP2 | RASEF | RABL2B, GDI1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEK6_RASEF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEK6_RASEF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NEK6 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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