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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24002

FusionGeneSummary for NEK11_FBN3

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK11_FBN3
Fusion gene ID: 24002
HgeneTgene
Gene symbol

NEK11

FBN3

Gene ID

79858

84467

Gene nameNIMA related kinase 11fibrillin 3
Synonyms--
Cytomap

3q22.1

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11fibrillin-3
Modification date2018052320180523
UniProtAcc

Q8NG66

Q75N90

Ensembl transtripts involved in fusion geneENST00000356918, ENST00000510769, 
ENST00000429253, ENST00000510688, 
ENST00000511262, ENST00000383366, 
ENST00000412440, ENST00000507910, 
ENST00000508196, ENST00000426022, 
ENST00000600128, ENST00000270509, 
ENST00000601739, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: NEK11 [Title/Abstract] AND FBN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK11

GO:0006468

protein phosphorylation

15161910|19734889

HgeneNEK11

GO:0031573

intra-S DNA damage checkpoint

15161910

HgeneNEK11

GO:0035556

intracellular signal transduction

15161910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3NK-01ANEK11chr3

130799432

+FBN3chr19

8197990

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356918ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000356918ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000356918ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510769ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510769ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510769ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000429253ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000429253ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000429253ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510688ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510688ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000510688ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000511262ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000511262ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000511262ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000383366ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000383366ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000383366ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000412440ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000412440ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000412440ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000507910ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000507910ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000507910ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000508196ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000508196ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
Frame-shiftENST00000508196ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000426022ENST00000600128NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000426022ENST00000270509NEK11chr3

130799432

+FBN3chr19

8197990

-
intron-3CDSENST00000426022ENST00000601739NEK11chr3

130799432

+FBN3chr19

8197990

-

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FusionProtFeatures for NEK11_FBN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK11

Q8NG66

FBN3

Q75N90

Protein kinase which plays an important role in the G2/Mcheckpoint response to DNA damage. Controls degradation of CDC25Aby directly phosphorylating it on residues whose phosphorylationis required for BTRC-mediated polyubiquitination and degradation.{ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889,ECO:0000269|PubMed:20090422}. Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occureither in association with elastin or in elastin-free bundles.Fibrillin-containing microfibrils provide long-term force bearingstructural support. {ECO:0000269|PubMed:14962672}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEK11_FBN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEK11_FBN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEK11APP, HSP90AA1, MYC, BLM, HERC2, FKBP5FBN3NUDT21, GSK3B, DAZAP2, BID, TK1, CDKN1A, RPS6KA6, PIK3R3, RPN2, ANXA7, TSC22D1, GADD45A, C11orf58


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEK11_FBN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNEK11Q8NG66DB08912DabrafenibSerine/threonine-protein kinase Nek11small moleculeapproved|investigational
TgeneFBN3Q75N90DB11093Calcium CitrateFibrillin-3small moleculeapproved
TgeneFBN3Q75N90DB11348Calcium PhosphateFibrillin-3small moleculeapproved

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RelatedDiseases for NEK11_FBN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource