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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24000

FusionGeneSummary for NEK11_DBNL

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK11_DBNL
Fusion gene ID: 24000
HgeneTgene
Gene symbol

NEK11

DBNL

Gene ID

79858

28988

Gene nameNIMA related kinase 11drebrin like
Synonyms-ABP1|HIP-55|HIP55|SH3P7
Cytomap

3q22.1

7p13

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11drebrin-like proteinHPK1-interacting protein of 55 kDaSH3 domain-containing protein 7actin-binding protein 1cervical SH3P7cervical mucin-associated proteindrebrin-Fsrc homology 3 domain-containing protein HIP-55
Modification date2018052320180522
UniProtAcc

Q8NG66

Q9UJU6

Ensembl transtripts involved in fusion geneENST00000356918, ENST00000510769, 
ENST00000429253, ENST00000510688, 
ENST00000511262, ENST00000383366, 
ENST00000412440, ENST00000507910, 
ENST00000508196, ENST00000426022, 
ENST00000448521, ENST00000456905, 
ENST00000440166, ENST00000452943, 
ENST00000468694, ENST00000494774, 
ENST00000490734, ENST00000497184, 
Fusion gene scores* DoF score4 X 4 X 4=643 X 3 X 1=9
# samples 43
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEK11 [Title/Abstract] AND DBNL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK11

GO:0006468

protein phosphorylation

15161910|19734889

HgeneNEK11

GO:0031573

intra-S DNA damage checkpoint

15161910

HgeneNEK11

GO:0035556

intracellular signal transduction

15161910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW835124NEK11chr3

130901108

+DBNLchr7

44100930

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356918ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000356918ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000356918ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000356918ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000356918ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000356918ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000356918ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000356918ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510769ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510769ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510769ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510769ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510769ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510769ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510769ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510769ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000429253ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000429253ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000429253ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000429253ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000429253ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000429253ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000429253ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000429253ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510688ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510688ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510688ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510688ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510688ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510688ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000510688ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000510688ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000511262ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000511262ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000511262ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000511262ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000511262ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000511262ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000511262ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000511262ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000383366ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000383366ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000383366ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000383366ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000383366ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000383366ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000383366ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000383366ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000412440ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000412440ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000412440ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000412440ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000412440ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000412440ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000412440ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000412440ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000507910ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000507910ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000507910ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000507910ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000507910ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000507910ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000507910ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000507910ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000508196ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000508196ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000508196ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000508196ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000508196ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000508196ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000508196ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000508196ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000426022ENST00000448521NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000426022ENST00000456905NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000426022ENST00000440166NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000426022ENST00000452943NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000426022ENST00000468694NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000426022ENST00000494774NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-intronENST00000426022ENST00000490734NEK11chr3

130901108

+DBNLchr7

44100930

-
intron-3UTRENST00000426022ENST00000497184NEK11chr3

130901108

+DBNLchr7

44100930

-

Top

FusionProtFeatures for NEK11_DBNL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK11

Q8NG66

DBNL

Q9UJU6

Protein kinase which plays an important role in the G2/Mcheckpoint response to DNA damage. Controls degradation of CDC25Aby directly phosphorylating it on residues whose phosphorylationis required for BTRC-mediated polyubiquitination and degradation.{ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889,ECO:0000269|PubMed:20090422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEK11_DBNL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NEK11_DBNL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NEK11_DBNL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNEK11Q8NG66DB08912DabrafenibSerine/threonine-protein kinase Nek11small moleculeapproved|investigational

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RelatedDiseases for NEK11_DBNL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDBNLC0005586Bipolar Disorder1PSYGENET