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Fusion gene ID: 23979 |
FusionGeneSummary for NEDD9_GOLGB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEDD9_GOLGB1 | Fusion gene ID: 23979 | Hgene | Tgene | Gene symbol | NEDD9 | GOLGB1 | Gene ID | 4739 | 2804 |
| Gene name | neural precursor cell expressed, developmentally down-regulated 9 | golgin B1 | |
| Synonyms | CAS-L|CAS2|CASL|CASS2|HEF1 | GCP|GCP372|GOLIM1 | |
| Cytomap | 6p24.2 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | enhancer of filamentation 1Cas scaffolding protein family member 2Crk-associated substrate related protein Cas-LEnhancer of filamentation 1 p55cas-like dockingneural precursor cell expressed developmentally down-regulated protein 9p130Cas-related pr | golgin subfamily B member 1372 kDa Golgi complex-associated proteingiantingolgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1golgi integral membrane protein 1golgin B1, golgi integral membrane proteinmacrogolgin | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14511 | Q14789 | |
| Ensembl transtripts involved in fusion gene | ENST00000504387, ENST00000379446, ENST00000379433, ENST00000508800, | ENST00000340645, ENST00000393667, ENST00000472829, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 8 X 7 X 4=224 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEDD9 [Title/Abstract] AND GOLGB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-EY-A3QX-01A | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000504387 | ENST00000340645 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| Frame-shift | ENST00000504387 | ENST00000393667 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| 5CDS-intron | ENST00000504387 | ENST00000472829 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| In-frame | ENST00000379446 | ENST00000340645 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| In-frame | ENST00000379446 | ENST00000393667 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| 5CDS-intron | ENST00000379446 | ENST00000472829 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| In-frame | ENST00000379433 | ENST00000340645 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| In-frame | ENST00000379433 | ENST00000393667 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| 5CDS-intron | ENST00000379433 | ENST00000472829 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| intron-3CDS | ENST00000508800 | ENST00000340645 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| intron-3CDS | ENST00000508800 | ENST00000393667 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
| intron-intron | ENST00000508800 | ENST00000472829 | NEDD9 | chr6 | 11213514 | - | GOLGB1 | chr3 | 121388202 | - |
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FusionProtFeatures for NEDD9_GOLGB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEDD9 | GOLGB1 |
| Docking protein which plays a central coordinating rolefor tyrosine-kinase-based signaling related to cell adhesion. Mayfunction in transmitting growth control signals between focaladhesions at the cell periphery and the mitotic spindle inresponse to adhesion or growth factor signals initiating cellproliferation. May play an important role in integrin beta-1 or Bcell antigen receptor (BCR) mediated signaling in B- and T-cells.Integrin beta-1 stimulation leads to recruitment of variousproteins including CRK, NCK and SHPTP2 to the tyrosinephosphorylated form. | May participate in forming intercisternal cross-bridgesof the Golgi complex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEDD9_GOLGB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_359aa MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQK LYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKFSQLLEEKNTLSIQLCDTSQSLRENQQ HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_364aa MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQK LYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKFSQLLEEKNTLSIQLCDTSQSLRENQQ HYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA AENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAIYFLMIHVLLILCFT >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_359aa MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQK LYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKFSQLLEEKNTLSIQLCDTSQSLRENQQ HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_364aa MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQK LYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKFSQLLEEKNTLSIQLCDTSQSLRENQQ HYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA AENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLAAIYFLMIHVLLILCFT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_1077nt ATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTG ACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTG AAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAG CTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTC CCCACTGGCCACGGCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTG GGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAG CACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGGGCCACTAAATATAGATGTTGCTCCA GGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAG CAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTC TCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAG CAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCAT >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_1092nt ATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTG ACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTG AAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAG CTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTC CCCACTGGCCACGGCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTG GGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAG CACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGTGAGTAAAGAGAAGGGGCCACTAAAT ATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTT TCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCT GCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCC TGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTG CGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACG >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_1077nt ATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTG ACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTG AAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAG CTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTC CCCACTGGCCACGGCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTG GGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAG CACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGGGCCACTAAATATAGATGTTGCTCCA GGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAG CAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTC TCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAG CAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCAT >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_1092nt ATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTG ACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTG AAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAG CTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTC CCCACTGGCCACGGCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTG GGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAG CACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGTGAGTAAAGAGAAGGGGCCACTAAAT ATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTT TCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCT GCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCC TGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTG CGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_2525nt ACAACAGTGAGCTCAGAGACTTGAGGGAGGCGCTGCGACTGACAAGCGGCTCTGCCCGGGACCTTCTCGCTTTCATCTAGCGCTGCACTC AATGGAGGGGCGGGCACCGCAGTGCTTAATGCTGTCTTAACTAGTGTAGGAAAACGGCTCAACCCACCGCTGCCGAAATGAAGTATAAGA ATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTGACCGTCATAGAGC AGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTGAAGCTTCTGATTG GTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAGCTCTATCAAGTGC CAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTCCCCACTGGCCACG GCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTGGGTAAAAAGTTCT CTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACC TTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGG AAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACA CCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGG AGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAA TAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAG TGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCT TTGGACCACTCCCCTCAAAACTTGGAATTCTCTCACCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTT CTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAACAGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTT CTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCTGAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCT GATCTTTTGTGGTCCTGTAAAAGATACTGAGGAATGTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCA GTATCATTTTGATTGATAACTTTCTTTGCCTTGTTTGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTC AGGGAAATGAACATGTCACCTCATAGGACATCTGATTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTT TAGCTGTTAGATCACATGGGAGGACAGCATCTTCTTCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAG GATAGAATCCCTTTGCTTTTGCCCTTGATCACATGTATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAA GTGTCTATGGACAGCAGGGTTCCAATTCTTGTCATTCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGC CACTGGGAGCCAATATTAGGCATTGACTCTCAGCCAGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAA GCTACTTTGCTGTTAGTGACAGTTATTACAGTTTCTCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACA AAATTAAATATAGATAGACCTGAGAAGGACAGCCAGGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTAC CAGTTGGTTATTTTCTCATTGCATACGTGATGTGTTCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTG CTCTAAATCTACTGTGGTGATTAAATCTTGGTTACAACATCCTGGGAAGTTTCCTGAACAACTGTAAAATAATAAAATTATTTTCAGAAT >In-frame_NEDD9_ENST00000379446_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_2536nt ACAACAGTGAGCTCAGAGACTTGAGGGAGGCGCTGCGACTGACAAGCGGCTCTGCCCGGGACCTTCTCGCTTTCATCTAGCGCTGCACTC AATGGAGGGGCGGGCACCGCAGTGCTTAATGCTGTCTTAACTAGTGTAGGAAAACGGCTCAACCCACCGCTGCCGAAATGAAGTATAAGA ATCTTATGGCAAGGGCCTTATATGACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTGACCGTCATAGAGC AGAACACAGGGGGACTGGAAGGATGGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTGAAGCTTCTGATTG GTCCCATGCAGGAGACTGCCTCCAGTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAGCTCTATCAAGTGC CAAACCCACAGGCTGCTCCCCGAGACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTCCCCACTGGCCACG GCACCCAAGAACAAGAGGTATATCAGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTGGGTAAAAAGTTCT CTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACC TTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCGGTGAGTAAAGAGAAGGGGCCACTAAATATAGATGTTGCTC CAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGC AGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTC TCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGG AGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTC ATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGA CTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTGGAATTCTCTCACCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTC CCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAACAGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGG CGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCTGAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAG ATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGATACTGAGGAATGTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTA ATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTCTTTGCCTTGTTTGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTG CCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCATAGGACATCTGATTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGA ACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGACAGCATCTTCTTCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAG GTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCCTTGATCACATGTATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACC AAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCAATTCTTGTCATTCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAG ACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATTGACTCTCAGCCAGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGAC CTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTTATTACAGTTTCTCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAG AATATAGAGAAGACAAAATTAAATATAGATAGACCTGAGAAGGACAGCCAGGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCC CCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCATACGTGATGTGTTCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGT GGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAAATCTTGGTTACAACATCCTGGGAAGTTTCCTGAACAACTGTAAAATAATAA >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000340645_chr3_121388202_-_2501nt GGGAGGCGCTGCGACTGACAAGCGGCTCTGCCCGGGACCTTCTCGCTTTCATCTAGCGCTGCACTCAATGGAGGGGCGGGCACCGCAGTG CTTAATGCTGTCTTAACTAGTGTAGGAAAACGGCTCAACCCACCGCTGCCGAAATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATG ACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTGACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGAT GGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTGAAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCA GTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAGCTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAG ACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTCCCCACTGGCCACGGCACCCAAGAACAAGAGGTATATC AGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTGGGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACA CCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGG AGAAGCAGGTTCAAGAGCTGCAGGCGGGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGA GTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAA GGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACA GTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTC GAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACT TTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTG GAATTCTCTCACCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTG CCTGCAAAAACAGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTT CTGCTTAATCTGAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGA TACTGAGGAATGTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTC TTTGCCTTGTTTGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCAT AGGACATCTGATTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGA CAGCATCTTCTTCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCC TTGATCACATGTATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCA ATTCTTGTCATTCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATT GACTCTCAGCCAGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTT ATTACAGTTTCTCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAATATAGATAGACCTGAG AAGGACAGCCAGGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCAT ACGTGATGTGTTCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAA >In-frame_NEDD9_ENST00000379433_chr6_11213514_-_GOLGB1_ENST00000393667_chr3_121388202_-_2512nt GGGAGGCGCTGCGACTGACAAGCGGCTCTGCCCGGGACCTTCTCGCTTTCATCTAGCGCTGCACTCAATGGAGGGGCGGGCACCGCAGTG CTTAATGCTGTCTTAACTAGTGTAGGAAAACGGCTCAACCCACCGCTGCCGAAATGAAGTATAAGAATCTTATGGCAAGGGCCTTATATG ACAATGTCCCAGAGTGTGCCGAGGAACTGGCCTTTCGCAAGGGAGACATCCTGACCGTCATAGAGCAGAACACAGGGGGACTGGAAGGAT GGTGGCTGTGCTCATTACACGGTCGGCAAGGCATTGTCCCAGGCAACCGGGTGAAGCTTCTGATTGGTCCCATGCAGGAGACTGCCTCCA GTCACGAGCAGCCTGCCTCTGGACTGATGCAGCAGACCTTTGGCCAACAGAAGCTCTATCAAGTGCCAAACCCACAGGCTGCTCCCCGAG ACACCATCTACCAAGTGCCACCTTCCTACCAAAATCAGGGAATTTACCAAGTCCCCACTGGCCACGGCACCCAAGAACAAGAGGTATATC AGGTGCCACCATCAGTGCAGAGAAGCATTGGGGGAACCAGTGGGCCCCACGTGGGTAAAAAGTTCTCTCAGCTACTGGAAGAGAAAAACA CCCTTTCCATTCAGCTCTGCGATACCAGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGG AGAAGCAGGTTCAAGAGCTGCAGGCGGTGAGTAAAGAGAAGGGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATG GAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGG AAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCA GACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTA CAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTC TAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCAC TCCCCTCAAAACTTGGAATTCTCTCACCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAAC TCTTCACGGAAAGTGCCTGCAAAAACAGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCC TGAGCCTGAACGCTTCTGCTTAATCTGAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTG TGGTCCTGTAAAAGATACTGAGGAATGTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTT TGATTGATAACTTTCTTTGCCTTGTTTGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATG AACATGTCACCTCATAGGACATCTGATTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTA GATCACATGGGAGGACAGCATCTTCTTCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATC CCTTTGCTTTTGCCCTTGATCACATGTATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATG GACAGCAGGGTTCCAATTCTTGTCATTCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAG CCAATATTAGGCATTGACTCTCAGCCAGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTG CTGTTAGTGACAGTTATTACAGTTTCTCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAAT ATAGATAGACCTGAGAAGGACAGCCAGGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTT ATTTTCTCATTGCATACGTGATGTGTTCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATC |
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FusionGenePPI for NEDD9_GOLGB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEDD9 | SMAD3, ITCH, CRKL, LYN, PTK2B, SH2D3C, BCAR3, RAPGEF1, PTPN12, BCAR1, NEDD9, ID2, FYN, CRK, LCK, NCK1, ABL1, PTK2, TRIP6, ZYX, PXN, SMAD1, SMAD2, MICAL1, PIK3CA, APP, NAB2, NFKBIA, REL, TRIM27, RBPMS, BANP, PRR20A, RFX6, NOTCH3, FZR1, AURKA, TCF3, DMRTB1, TFCP2, CTTN, SMURF2, RHEB, KLHL18 | GOLGB1 | BRMS1, KIAA1377, PFN2, ACBD3, USO1, UBE2I, MAPK7, SREBF2, ITSN2, KIAA0368, ERGIC1, SKIL, CUL7, OBSL1, CCDC8, TEX35, TMED10, SCGN, C17orf59, LPAR1, USP7, NUP35, EWSR1, GAK, DYNLL1, CEP135, CCDC93, CDC5L, ATOH1, CDH1, EGFR, TMED2, IPPK, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEDD9_GOLGB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEDD9_GOLGB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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