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Fusion gene ID: 23975 |
FusionGeneSummary for NEDD8_NRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEDD8_NRL | Fusion gene ID: 23975 | Hgene | Tgene | Gene symbol | NEDD8 | NRL | Gene ID | 4738 | 4901 |
| Gene name | neural precursor cell expressed, developmentally down-regulated 8 | neural retina leucine zipper | |
| Synonyms | NEDD-8 | D14S46E|NRL-MAF|RP27 | |
| Cytomap | 14q12 | 14q11.2-q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NEDD8neddylinubiquitin-like protein Nedd8 | neural retina-specific leucine zipper proteinneural retinal-specific leucine zipper | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q15843 | P54845 | |
| Ensembl transtripts involved in fusion gene | ENST00000250495, ENST00000524927, ENST00000533242, | ENST00000397002, ENST00000561028, ENST00000396997, ENST00000560550, ENST00000396995, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 6 X 4=120 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEDD8 [Title/Abstract] AND NRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEDD8 | GO:0045116 | protein neddylation | 10500095 |
| Tgene | NRL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8552602 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-LN-A49L-01A | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000250495 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000250495 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000250495 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000250495 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000250495 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| In-frame | ENST00000524927 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000524927 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000524927 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000524927 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000524927 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
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FusionProtFeatures for NEDD8_NRL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEDD8 | NRL |
| Ubiquitin-like protein which plays an important role incell cycle control and embryogenesis. Covalent attachment to itssubstrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 tocullins activates their associated E3 ubiquitin ligase activity,and thus promotes polyubiquitination and proteasomal degradationof cyclins and other regulatory proteins.{ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293,ECO:0000269|PubMed:11953428}. | Acts as a transcriptional activator which regulates theexpression of several rod-specific genes, including RHO and PDE6B(PubMed:21981118). Functions also as a transcriptionalcoactivator, stimulating transcription mediated by thetranscription factor CRX and NR2E3 (PubMed:17335001). Binds in asequence-specific manner to the rhodopsin promoter(PubMed:17335001). {ECO:0000269|PubMed:17335001,ECO:0000269|PubMed:21981118}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | - | 2 | 4 | 159_222 | 127 | 238 | Domain | bZIP |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | - | 1 | 3 | 159_222 | 127 | 238 | Domain | bZIP |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | - | 1 | 3 | 159_222 | 127 | 238 | Domain | bZIP |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | - | 2 | 4 | 159_185 | 127 | 238 | Region | Basic motif |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | - | 2 | 4 | 187_208 | 127 | 238 | Region | Leucine-zipper |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | - | 1 | 3 | 159_185 | 127 | 238 | Region | Basic motif |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | - | 1 | 3 | 187_208 | 127 | 238 | Region | Leucine-zipper |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | - | 1 | 3 | 159_185 | 127 | 238 | Region | Basic motif |
| Tgene | >NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | - | 1 | 3 | 187_208 | 127 | 238 | Region | Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | - | 2 | 4 | 30_93 | 127 | 238 | Region | Minimal transactivation domain (MTD) |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | - | 1 | 3 | 30_93 | 127 | 238 | Region | Minimal transactivation domain (MTD) |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | - | 1 | 3 | 30_93 | 127 | 238 | Region | Minimal transactivation domain (MTD) |
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FusionGeneSequence for NEDD8_NRL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEDD8_ENST00000250495_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_117aa MLIKVKLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARE >In-frame_NEDD8_ENST00000524927_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_117aa MLIKVKLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEDD8_ENST00000250495_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_351nt ATGCTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCTGCGGGGC TGCGGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAAGCGGCTG CAGCAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGCCCGGGAG >In-frame_NEDD8_ENST00000524927_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_351nt ATGCTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCTGCGGGGC TGCGGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAAGCGGCTG CAGCAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGCCCGGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEDD8_ENST00000250495_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_1667nt TGAACCGAAACGCGGGAGCAACCCTGAGCCTTTCCGGAACCCAGTGGGGGGGGGGGGGGGGGTGGAGCCAGACAGTGACCCGGAAGTAGA AGTGGCCCTTGCAGGCAAGAGTGCTGGAGGGCGGCAGCGGCGACCGGAGCGGTAGGAGCAGCAATTTATCCGTGTGCAGCCCCAAACTGG AAAGAAGATGCTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCT GCGGGGCTGCGGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAA GCGGCTGCAGCAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGC CCGGGAGCGCGATCTCTACAAGGCTCGCTGTGACCGGCTAACCTCGAGCGGCCCCGGGTCCGGGGACCCCTCCCACCTCTTCCTCTGAGC CGTTCAGAGCACCTTGTGGTGTAGTGGGGGCTGGGTGGGGTGGCTCCGCCCAGGAGGCGGCTGCACGGTTCTCTGCATCGTTACCAGAGC GCCTTCTGGTCCTAGCCACGCCCTGTATGACCGCGCAAATATCCCCAAAGCTTTTGGGTCCTCAAGTCATGCCCGAATTTAGATGCTGGT CATTTTCTGGAGAGGGGTCCCCTCCCCTTACGAACACAGAAACCCAGCCCACATGACTAGCACGCTGAGCTCTGCAGGGACCAGTGCCAG GCACTGGGGGGTGGAAGTGTGGTGACACAGTGAATGGGAGGTGGAGGAGGGTTGCAGCTCCCACCTCAGTTTAGTTTTTAATTCAGGGTT TTCAACCTGTAACACATTAAAGCTGTAATTAGCAATGAGGCTGTATTTTCATTCTGAAGCTTGTAACCTCCCCATTTTAGCACTACAGAA TTTTCAAGATTTCAATATCCAACAACTAGATAGATTAGGACCTCTATCCGAGATGCTTTTTCCCTGCCCAACCCTGTGGCCTTCAGGGCT CAGAGCAGCAAAGGCCTGAAGAGTGAGCTCTGGGGGTTGTTGGTGTGGGTTGGGAGAGAGCTGTGTGCAGAAGTCTGGAAACCTGGGTCC TAGTCCCAGCTCTTCCATGGGATCCCCCTGTCACCCTGAGCAAATCAGTTGCTTCCTGGACTTGTGTTACTTCATCTAATTCTCATGTGG ATTGGACGACTTCTGCTCCCTTTCCAGTTCTGGCATCTCCCCAGTATGGAAGTCCCGGTGGTCTCCCCAAGAAGTCCCCAAGACAATCTC GCCAAAGGCACCTCCTATCCTGCTGCAGTTTCCCAGCTGCAGCCTAGGCAGGGGATGCACAGCCCAGGCGAGGAAGCCTGGCTTCTCTGT GAGCACATACGTGGGTCCTCGGCAGCTCCCTCCAGGCTGTCTGGGCCTCCAGACCTGCACAGGGTGCTCCTGCCACCTCCCACCTCTCTG AGGGCTGAGGTGAGACTTCTCCTGGGATGACAATTTGCTGAGAGAGTGCAGCTTTTGTGAATTAAACTTGAAGTCCAGGCAGAATTCTAA >In-frame_NEDD8_ENST00000524927_chr14_24701456_-_NRL_ENST00000397002_chr14_24550777_-_1567nt GCAGGCAAGAGTGCTGGAGGGCGGCAGCGGCGACCGGAGCGGTAGGAGCAGCAATTTATCCGTGTGCAGCCCCAAACTGGAAAGAAGATG CTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCTGCGGGGCTGC GGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAAGCGGCTGCAG CAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGCCCGGGAGCGC GATCTCTACAAGGCTCGCTGTGACCGGCTAACCTCGAGCGGCCCCGGGTCCGGGGACCCCTCCCACCTCTTCCTCTGAGCCGTTCAGAGC ACCTTGTGGTGTAGTGGGGGCTGGGTGGGGTGGCTCCGCCCAGGAGGCGGCTGCACGGTTCTCTGCATCGTTACCAGAGCGCCTTCTGGT CCTAGCCACGCCCTGTATGACCGCGCAAATATCCCCAAAGCTTTTGGGTCCTCAAGTCATGCCCGAATTTAGATGCTGGTCATTTTCTGG AGAGGGGTCCCCTCCCCTTACGAACACAGAAACCCAGCCCACATGACTAGCACGCTGAGCTCTGCAGGGACCAGTGCCAGGCACTGGGGG GTGGAAGTGTGGTGACACAGTGAATGGGAGGTGGAGGAGGGTTGCAGCTCCCACCTCAGTTTAGTTTTTAATTCAGGGTTTTCAACCTGT AACACATTAAAGCTGTAATTAGCAATGAGGCTGTATTTTCATTCTGAAGCTTGTAACCTCCCCATTTTAGCACTACAGAATTTTCAAGAT TTCAATATCCAACAACTAGATAGATTAGGACCTCTATCCGAGATGCTTTTTCCCTGCCCAACCCTGTGGCCTTCAGGGCTCAGAGCAGCA AAGGCCTGAAGAGTGAGCTCTGGGGGTTGTTGGTGTGGGTTGGGAGAGAGCTGTGTGCAGAAGTCTGGAAACCTGGGTCCTAGTCCCAGC TCTTCCATGGGATCCCCCTGTCACCCTGAGCAAATCAGTTGCTTCCTGGACTTGTGTTACTTCATCTAATTCTCATGTGGATTGGACGAC TTCTGCTCCCTTTCCAGTTCTGGCATCTCCCCAGTATGGAAGTCCCGGTGGTCTCCCCAAGAAGTCCCCAAGACAATCTCGCCAAAGGCA CCTCCTATCCTGCTGCAGTTTCCCAGCTGCAGCCTAGGCAGGGGATGCACAGCCCAGGCGAGGAAGCCTGGCTTCTCTGTGAGCACATAC GTGGGTCCTCGGCAGCTCCCTCCAGGCTGTCTGGGCCTCCAGACCTGCACAGGGTGCTCCTGCCACCTCCCACCTCTCTGAGGGCTGAGG TGAGACTTCTCCTGGGATGACAATTTGCTGAGAGAGTGCAGCTTTTGTGAATTAAACTTGAAGTCCAGGCAGAATTCTAATGCAATAAGC |
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FusionGenePPI for NEDD8_NRL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEDD8 | FBXO4, MAGED1, VHL, CDK2, TFE3, UCHL1, AHR, RBX1, CUL4A, UCHL3, NUB1, PSMD4, UBA2, COPS5, COPS6, USP13, USP25, DDB1, UBA3, NAE1, UBE2M, SENP8, DNMT3B, UBC, BTRC, UBXN7, SKP1, CUL1, CUL2, CUL3, TCEB2, TCEB1, MEI1, COPS2, COPS3, COPS4, COPS7A, ZYX, CUL4B, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, CTRC, UBE2D2, CUL5, DCUN1D1, ACTB, ACTBL2, AHCY, ARIH1, BAG4, BTBD9, C1QBP, DFFB, CIRBP, CLTC, CLTCL1, COPS7B, COPS8, YBX3, CTPS1, DAZAP1, DCTPP1, DDX1, DDX17, DDX3X, DDX5, DHX9, DNAJC10, DSP, EEF1A1, EEF1A2, EEF1G, EWSR1, FBXO3, FBXW11, FEM1B, FUS, GAPDH, GPS1, HIST1H1C, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPR, HNRNPU, HNRNPUL1, HNRNPDL, HSP90AA1, HSP90AA2P, HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA5, HSPA6, HSPA7, HSPA8, HSPA9, HSPD1, IGF2BP1, ILF2, ILF3, KBTBD6, KBTBD7, KCTD10, KCTD3, KHSRP, KLHDC10, KLHL12, KLHL15, KLHL22, KLHL9, KPNA2, KRT1, KRT10, KRT13, KRT14, KRT16, KRT2, KRT24, KRT5, KRT75, KRT76, KRT9, LGALS3BP, IGHV3OR15-7, MATR3, MYEOV2, NCL, NEDD8, NUDT16L1, NUP155, PABPC1, PPIA, PRDX1, PWP1, QPCT, RNF187, RPL10P16, RPL11, RPL15, RPL19, RPL23A, RPL31, RPL35, RPL36AP37, HNRNPH2, RPL4, RPL5, RPL6, RPL7AP9, RPL8, RPLP0, RPLP1, RPLP2, RPS10, RPS15A, RPS16, RPS20, RPS23, RPS3, RPS3A, RPS4X, RPS8, RPSAP12, RPSAP55, SDHA, SEC23A, SERBP1, SRSF2, SRSF7, SHKBP1, SNRPC, SNRPD1, SPTAN1, SPTBN1, SSB, STRBP, SYNCRIP, TAF15, TBC1D15, TCEB1P3, TFG, TIAL1, TNRC6B, TTN, TUBA1C, TUBA4A, TUBB, TUBB4B, USP11, VPRBP, DCAF11, YBX1, YWHAE, YWHAQ, YWHAZ, ZYG11B, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, FBXO6, ATXN3, OR4S2, TST, CLNS1A, NDUFS6, IGBP1, HRAS, CPLX1, MSRB2, BRAP, ARIH2, ASL, GDI1, POP1, ASB8, SHFM1, HGS, OTUB1, KLHDC3, ATP6V1F, HIBCH, MEMO1, MPI, C9orf64, DNAJC8, HMGCS1, PPA2, TKT, UBE2D3, UFC1, YAP1, NIT1, PRDX5, RAB8B, GHR, SMURF2, SMURF1, TCEB3 | NRL | FIZ1, EDF1, OPTN, NR2E3, CRX |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NEDD8 | chr14:24701456 | chr14:24550777 | ENST00000250495 | - | 1 | 4 | 70_72 | 6 | 82 | UBE1C |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEDD8_NRL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEDD8_NRL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NRL | C0028077 | Night Blindness | 2 | CTD_human;HPO |
| Tgene | NRL | C0035334 | Retinitis Pigmentosa | 2 | CTD_human;HPO;ORPHANET |
| Tgene | NRL | C1834329 | RETINITIS PIGMENTOSA 27 | 2 | UNIPROT |
| Tgene | NRL | C0035304 | Retinal Degeneration | 1 | CTD_human |
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