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Fusion gene ID: 23968 |
FusionGeneSummary for NEDD4_ARMCX3 |
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Fusion gene information | Fusion gene name: NEDD4_ARMCX3 | Fusion gene ID: 23968 | Hgene | Tgene | Gene symbol | NEDD4 | ARMCX3 | Gene ID | 4734 | 51566 |
Gene name | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | armadillo repeat containing X-linked 3 | |
Synonyms | NEDD4-1|RPF1 | ALEX3|GASP6|dJ545K15.2 | |
Cytomap | 15q21.3 | Xq22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase NEDD4HECT-type E3 ubiquitin transferase NEDD4cell proliferation-inducing gene 53 proteinreceptor-potentiating factor 1 | armadillo repeat-containing X-linked protein 31200004E24RikARM protein lost in epithelial cancers on chromosome X 3arm protein lost in epithelial cancers, X chromosome, 3 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P46934 | Q9UH62 | |
Ensembl transtripts involved in fusion gene | ENST00000435532, ENST00000338963, ENST00000508342, ENST00000506154, ENST00000508075, | ENST00000341189, ENST00000471229, ENST00000477980, ENST00000537169, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 1=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: NEDD4 [Title/Abstract] AND ARMCX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NEDD4 | GO:0006511 | ubiquitin-dependent protein catabolic process | 20086093 |
Hgene | NEDD4 | GO:0006622 | protein targeting to lysosome | 17116753 |
Hgene | NEDD4 | GO:0007041 | lysosomal transport | 18544533 |
Hgene | NEDD4 | GO:0010766 | negative regulation of sodium ion transport | 10642508 |
Hgene | NEDD4 | GO:0016567 | protein ubiquitination | 17996703|18305167|25631046|26280536 |
Hgene | NEDD4 | GO:0031623 | receptor internalization | 18544533 |
Hgene | NEDD4 | GO:0032801 | receptor catabolic process | 18544533 |
Hgene | NEDD4 | GO:0034765 | regulation of ion transmembrane transport | 17289006 |
Hgene | NEDD4 | GO:0042391 | regulation of membrane potential | 17289006 |
Hgene | NEDD4 | GO:0042921 | glucocorticoid receptor signaling pathway | 8649367 |
Hgene | NEDD4 | GO:0045732 | positive regulation of protein catabolic process | 14973438 |
Hgene | NEDD4 | GO:0046824 | positive regulation of nucleocytoplasmic transport | 17218261 |
Hgene | NEDD4 | GO:0050847 | progesterone receptor signaling pathway | 8649367 |
Hgene | NEDD4 | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 17289006 |
Hgene | NEDD4 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 10642508 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA449165 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000435532 | ENST00000341189 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000435532 | ENST00000471229 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-intron | ENST00000435532 | ENST00000477980 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000435532 | ENST00000537169 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000338963 | ENST00000341189 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000338963 | ENST00000471229 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-intron | ENST00000338963 | ENST00000477980 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000338963 | ENST00000537169 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508342 | ENST00000341189 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508342 | ENST00000471229 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-intron | ENST00000508342 | ENST00000477980 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508342 | ENST00000537169 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000506154 | ENST00000341189 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000506154 | ENST00000471229 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-intron | ENST00000506154 | ENST00000477980 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000506154 | ENST00000537169 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508075 | ENST00000341189 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508075 | ENST00000471229 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-intron | ENST00000508075 | ENST00000477980 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
intron-3UTR | ENST00000508075 | ENST00000537169 | NEDD4 | chr15 | 56195177 | - | ARMCX3 | chrX | 100881405 | + |
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FusionProtFeatures for NEDD4_ARMCX3 |
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Hgene | Tgene |
NEDD4 | ARMCX3 |
Regulates mitochondrial aggregation and transport inaxons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2.Mitochondrial distribution and dynamics is regulated throughARMCX3 protein degradation, which is promoted by PCK andnegatively regulated by WNT1. Enhances the SOX10-mediatedtransactivation of the neuronal acetylcholine receptor subunitalpha-3 and beta-4 subunit gene promoters.{ECO:0000250|UniProtKB:Q8BHS6}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEDD4_ARMCX3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEDD4_ARMCX3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEDD4_ARMCX3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEDD4_ARMCX3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NEDD4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | NEDD4 | C0022548 | Keloid | 1 | CTD_human |
Hgene | NEDD4 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Hgene | NEDD4 | C0151744 | Myocardial Ischemia | 1 | CTD_human |