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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23946

FusionGeneSummary for NEDD1_GPHN

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD1_GPHN
Fusion gene ID: 23946
HgeneTgene
Gene symbol

NEDD1

GPHN

Gene ID

121441

10243

Gene nameneural precursor cell expressed, developmentally down-regulated 1gephyrin
SynonymsGCP-WD|TUBGCP7GEPH|GPH|GPHRYN|HKPX1|MOCODC
Cytomap

12q23.1

14q23.3-q24.1

Type of geneprotein-codingprotein-coding
Descriptionprotein NEDD1NEDD-1neural precursor cell expressed developmentally down-regulated protein 1gephyrin
Modification date2018052320180523
UniProtAcc

Q8NHV4

Q9NQX3

Ensembl transtripts involved in fusion geneENST00000266742, ENST00000429527, 
ENST00000555114, ENST00000411739, 
ENST00000557644, ENST00000457368, 
ENST00000315266, ENST00000478722, 
ENST00000459628, ENST00000543237, 
ENST00000305960, ENST00000544752, 
Fusion gene scores* DoF score4 X 4 X 1=169 X 13 X 12=1404
# samples 420
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(20/1404*10)=-2.81147103052984
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEDD1 [Title/Abstract] AND GPHN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPHN

GO:0032324

molybdopterin cofactor biosynthetic process

26613940

TgeneGPHN

GO:0097112

gamma-aminobutyric acid receptor clustering

26613940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2O-01ANEDD1chr12

97301078

+GPHNchr14

67431908

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000266742ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000266742ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000266742ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000266742ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000266742ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3UTRENST00000266742ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000429527ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000429527ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000429527ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000429527ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000429527ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3UTRENST00000429527ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3CDSENST00000555114ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3CDSENST00000555114ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3CDSENST00000555114ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3CDSENST00000555114ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3CDSENST00000555114ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
3UTR-3UTRENST00000555114ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000411739ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000411739ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000411739ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000411739ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3CDSENST00000411739ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
5UTR-3UTRENST00000411739ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000557644ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000557644ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000557644ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000557644ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000557644ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3UTRENST00000557644ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000457368ENST00000315266NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000457368ENST00000478722NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000457368ENST00000459628NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000457368ENST00000543237NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3CDSENST00000457368ENST00000305960NEDD1chr12

97301078

+GPHNchr14

67431908

+
intron-3UTRENST00000457368ENST00000544752NEDD1chr12

97301078

+GPHNchr14

67431908

+

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FusionProtFeatures for NEDD1_GPHN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD1

Q8NHV4

GPHN

Q9NQX3

Required for mitosis progression. Promotes thenucleation of microtubules from the spindle.{ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. Microtubule-associated protein involved in membraneprotein-cytoskeleton interactions. It is thought to anchor theinhibitory glycine receptor (GLYR) to subsynaptic microtubules.Catalyzes two steps in the biosynthesis of the molybdenumcofactor. In the first step, molybdopterin is adenylated.Subsequently, molybdate is inserted into adenylated molybdopterinand AMP is released. {ECO:0000269|PubMed:26613940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEDD1_GPHN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEDD1_GPHN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEDD1EP300, HAUS6, CEP192, FBLN1, ACTB, CAPNS1, CASK, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CHCHD1, CILP, CRTC2, CRTC3, TUBB, HSPA1A, DCST1, MRPS18B, FAM117B, MZT2B, HNRNPA1, HNRNPA2B1, HNRNPF, HNRNPU, HSPA1L, HSPA9, IRS4, LY6G5B, LYZ, MRPL46, MRPS26, MYO15B, TUBGCP3, RPL13, PFDN2, RAVER1, RPL3, RPL38, RPS19, RPS2, RPS3, RPS3A, RPS4X, RPS9, SCO2, TCEAL4, TCP1, TFAM, ALYREF, TMPRSS13, TUBA1C, TUBG1, TUBGCP4, TUBGCP6, ZWINT, TRAK2, PARP16, IFT57, PSMC3, BTRC, PLK4, CENPJ, CEP152, SSX2IP, OFD1, PCM1, CCP110, CEP97, CEP170, CEP104, CEP162, CEP290, CNTROB, SPICE1, CEP128, CEP135, CEP44, CNTRL, FBF1, NINL, NIN, ODF2, SCLT1, DCTN1, CEP83, LCA5, SASS6, STIL, XPO1, ARL1, CRY1, ECHS1, HELLS, LGALS3BP, MAP3K4, PLCB3, PPM1A, RPL27, YBX3, TRADD, ATP5J2, TOMM20, POLR3F, FARS2, TUBGCP2, AFG3L2, CEP131, WDFY3, ZNF292, FBXO28, MTCL1, NME7, TXNDC11, PPHLN1, NUP54, UHRF1BP1, CDCA8, CEP72, HERPUD2, DERL1, C10orf88, MAGT1, ZNF644, ING5, CCDC77, TUBGCP5, SCAF11, NRBP2, MZT1, MZT2A, SSSCA1, CAMK2D, PFDN4, HSPBP1, NCAPH2, CD2BP2GPHNARHGEF9, GLRB, MTOR, PFN1, OTUD4, PRPF4, PCK1, SPATS1, GPHN, KHDRBS1, ACADVL, BRCC3, MTA2, PAAF1, PPP4R1, ROCK2, SPTAN1, TSSK1B, ODF3L2, NTRK1, DYNLL1, CDCA5, TCF4, SENP3, VASP, ENAH, KLKB1, KMO, LGALS3BP, STS, DYNLL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEDD1_GPHN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEDD1_GPHN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPHNC0001973Alcoholic Intoxication, Chronic1CTD_human
TgeneGPHNC0236736Cocaine-Related Disorders1CTD_human
TgeneGPHNC1854990Molybdenum Cofactor Deficiency, Complementation Group C1ORPHANET;UNIPROT