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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23936

FusionGeneSummary for NEBL_ZNHIT3

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL_ZNHIT3
Fusion gene ID: 23936
HgeneTgene
Gene symbol

NEBL

ZNHIT3

Gene ID

10529

9326

Gene namenebulettezinc finger HIT-type containing 3
SynonymsLASP2|LNEBLPEHO|TRIP3
Cytomap

10p12.31

17q12

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteinzinc finger HIT domain-containing protein 3HNF-4a coactivatorTR-interacting protein 3TRIP-3thyroid hormone receptor interactor 3thyroid receptor interacting protein 3zinc finger, HIT domain containing 3zinc finger, HIT type 3
Modification date2018052320180519
UniProtAcc

O76041

Q15649

Ensembl transtripts involved in fusion geneENST00000377122, ENST00000417816, 
ENST00000377159, ENST00000377119, 
ENST00000464278, 
ENST00000490126, 
ENST00000225410, ENST00000588253, 
ENST00000592616, ENST00000590858, 
Fusion gene scores* DoF score8 X 7 X 4=2244 X 4 X 3=48
# samples 104
** MAII scorelog2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEBL [Title/Abstract] AND ZNHIT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-C5-A3HD-01BNEBLchr10

21101698

-ZNHIT3chr17

34853450

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377122ENST00000490126NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-intronENST00000377122ENST00000225410NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377122ENST00000588253NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377122ENST00000592616NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377122ENST00000590858NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-intronENST00000417816ENST00000490126NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-intronENST00000417816ENST00000225410NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000417816ENST00000588253NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000417816ENST00000592616NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000417816ENST00000590858NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-intronENST00000377159ENST00000490126NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-intronENST00000377159ENST00000225410NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377159ENST00000588253NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377159ENST00000592616NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
5CDS-5UTRENST00000377159ENST00000590858NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-intronENST00000377119ENST00000490126NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-intronENST00000377119ENST00000225410NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000377119ENST00000588253NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000377119ENST00000592616NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000377119ENST00000590858NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-intronENST00000464278ENST00000490126NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-intronENST00000464278ENST00000225410NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000464278ENST00000588253NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000464278ENST00000592616NEBLchr10

21101698

-ZNHIT3chr17

34853450

+
intron-5UTRENST00000464278ENST00000590858NEBLchr10

21101698

-ZNHIT3chr17

34853450

+

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FusionProtFeatures for NEBL_ZNHIT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

ZNHIT3

Q15649

Binds to actin and plays an important role in theassembly of the Z-disk. May functionally link sarcomeric actin tothe desmin intermediate filaments in the heart muscle sarcomeres(PubMed:27733623). Isoform 2 might play a role in the assembly offocal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028,ECO:0000269|PubMed:27733623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEBL_ZNHIT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEBL_ZNHIT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEBLMYPN, ZYX, MED28, XIRP2, XIRP1, PRKAB2, TRIM63, TRIM55, ACTN3, GOLGA2, TRIM27, TRAF1, TRAF2, MAD1L1, HOMER3, GMCL1, CCDC136, LZTS2, MIPOL1, FAM9B, NUTM1, ZDHHC17, CEP170, CEP128, SCLT1, DCTN1, CDH1, ZNF764, GCHFR, DHX38, CARKDZNHIT3HNF4A, MEIS2, PBX3, PITX2, XRCC3, ZNF24, FAIM3, ESR2, PPARG, CSNK2A2, MBNL1, MOV10, NUFIP1, FBL, HECTD1, XPO1, LLGL2, RALA, CKAP5, NHP2L1, RUVBL1, ZNF324B, NOP58, ZNHIT6, PRPF19, USP11, ZNHIT3, TRIM25, PRPF31, RNU4-1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEBL_ZNHIT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEBL_ZNHIT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource