FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23923

FusionGeneSummary for NEAT1_PPM1A

check button Fusion gene summary
Fusion gene informationFusion gene name: NEAT1_PPM1A
Fusion gene ID: 23923
HgeneTgene
Gene symbol

NEAT1

PPM1A

Gene ID

283131

5494

Gene namenuclear paraspeckle assembly transcript 1protein phosphatase, Mg2+/Mn2+ dependent 1A
SynonymsLINC00084|NCRNA00084|TncRNA|VINCPP2C-ALPHA|PP2CA|PP2Calpha
Cytomap

11q13.1

14q23.1

Type of genencRNAprotein-coding
DescriptionMENepsilon/betalong intergenic non-protein coding RNA 84nuclear enriched abundant transcript 1nuclear paraspeckle assembly transcript 1 (non-protein coding)trophoblast MHC class II suppressortrophoblast-derived noncoding RNAvirus inducible non-codinprotein phosphatase 1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Modification date2018052020180519
UniProtAcc

P35813

Ensembl transtripts involved in fusion geneENST00000384994, ENST00000325642, 
ENST00000529574, ENST00000395076, 
ENST00000325658, 
Fusion gene scores* DoF score24 X 30 X 3=21604 X 4 X 2=32
# samples 314
** MAII scorelog2(31/2160*10)=-2.80069119177659
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEAT1 [Title/Abstract] AND PPM1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPM1A

GO:0010991

negative regulation of SMAD protein complex assembly

16751101

TgenePPM1A

GO:0016055

Wnt signaling pathway

10644691

TgenePPM1A

GO:0016311

dephosphorylation

10644691

TgenePPM1A

GO:0030177

positive regulation of Wnt signaling pathway

10644691

TgenePPM1A

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

16751101

TgenePPM1A

GO:0035970

peptidyl-threonine dephosphorylation

11559703|20801214

TgenePPM1A

GO:0045893

positive regulation of transcription, DNA-templated

10644691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG485165NEAT1chr11

65193452

+PPM1Achr14

60754624

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000384994ENST00000325642NEAT1chr11

65193452

+PPM1Achr14

60754624

+
intron-intronENST00000384994ENST00000529574NEAT1chr11

65193452

+PPM1Achr14

60754624

+
intron-intronENST00000384994ENST00000395076NEAT1chr11

65193452

+PPM1Achr14

60754624

+
intron-3UTRENST00000384994ENST00000325658NEAT1chr11

65193452

+PPM1Achr14

60754624

+

Top

FusionProtFeatures for NEAT1_PPM1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEAT1

PPM1A

P35813

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Enzyme with a broad specificity. Negatively regulatesTGF-beta signaling through dephosphorylating SMAD2 and SMAD3,resulting in their dissociation from SMAD4, nuclear export of theSMADs and termination of the TGF-beta-mediated signaling.Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in thetermination of TNF-alpha-mediated NF-kappa-B activation throughdephosphorylating and inactivating IKBKB/IKKB.{ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NEAT1_PPM1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NEAT1_PPM1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NEAT1_PPM1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NEAT1_PPM1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEAT1C0023903Liver neoplasms1CTD_human
HgeneNEAT1C3495559Juvenile arthritis1CTD_human