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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2392

FusionGeneSummary for ARHGAP21_CALN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP21_CALN1
Fusion gene ID: 2392
HgeneTgene
Gene symbol

ARHGAP21

CALN1

Gene ID

57584

83698

Gene nameRho GTPase activating protein 21calneuron 1
SynonymsARHGAP10CABP8
Cytomap

10p12.1|10p12.3

7q11.22

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 21Rho-GTPase activating protein 10rho GTPase-activating protein 10rho-type GTPase-activating protein 21calcium-binding protein 8calcium-binding protein CABP8calneuron I
Modification date2018052320180519
UniProtAcc

Q5T5U3

Q9BXU9

Ensembl transtripts involved in fusion geneENST00000396432, ENST00000320481, 
ENST00000493154, 
ENST00000329008, 
ENST00000395275, ENST00000395276, 
ENST00000405452, ENST00000412588, 
ENST00000431984, 
Fusion gene scores* DoF score9 X 7 X 6=3783 X 3 X 3=27
# samples 93
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP21 [Title/Abstract] AND CALN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP21

GO:0051683

establishment of Golgi localization

20525016


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF930876ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000396432ENST00000329008ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000396432ENST00000395275ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000396432ENST00000395276ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000396432ENST00000405452ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000396432ENST00000412588ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000396432ENST00000431984ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000329008ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000395275ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000395276ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000405452ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000412588ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000320481ENST00000431984ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000329008ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000395275ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000395276ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000405452ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000412588ARHGAP21chr10

24955256

-CALN1chr7

71511039

-
intron-intronENST00000493154ENST00000431984ARHGAP21chr10

24955256

-CALN1chr7

71511039

-

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FusionProtFeatures for ARHGAP21_CALN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP21

Q5T5U3

CALN1

Q9BXU9

Functions as a GTPase-activating protein (GAP) for RHOAand CDC42. Downstream partner of ARF1 which may control Golgiapparatus structure and function. Also required for CTNNA1recruitment to adherens junctions. {ECO:0000269|PubMed:15793564,ECO:0000269|PubMed:16184169}. Negatively regulates Golgi-to-plasma membranetrafficking by interacting with PI4KB and inhibiting its activity(By similarity). May play a role in the physiology of neurons andis potentially important in memory and learning. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP21_CALN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP21_CALN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP21_CALN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP21_CALN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource