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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23913

FusionGeneSummary for NEAT1_IFNAR2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEAT1_IFNAR2
Fusion gene ID: 23913
HgeneTgene
Gene symbol

NEAT1

IFNAR2

Gene ID

283131

3455

Gene namenuclear paraspeckle assembly transcript 1interferon alpha and beta receptor subunit 2
SynonymsLINC00084|NCRNA00084|TncRNA|VINCIFN-R|IFN-alpha-REC|IFNABR|IFNARB|IMD45
Cytomap

11q13.1

21q22.11

Type of genencRNAprotein-coding
DescriptionMENepsilon/betalong intergenic non-protein coding RNA 84nuclear enriched abundant transcript 1nuclear paraspeckle assembly transcript 1 (non-protein coding)trophoblast MHC class II suppressortrophoblast-derived noncoding RNAvirus inducible non-codininterferon alpha/beta receptor 2IFN-R-2IFN-alpha/beta receptor 2human interferon alpha/beta receptorinterferon (alpha, beta and omega) receptor 2interferon alpha binding proteininterferon receptorinterferon-alpha/beta receptor beta chaintype I int
Modification date2018052020180523
UniProtAcc

P48551

Ensembl transtripts involved in fusion geneENST00000384994, ENST00000382264, 
ENST00000382241, ENST00000404220, 
ENST00000342136, ENST00000420068, 
ENST00000342101, ENST00000413881, 
Fusion gene scores* DoF score24 X 30 X 3=21601 X 1 X 1=1
# samples 311
** MAII scorelog2(31/2160*10)=-2.80069119177659
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NEAT1 [Title/Abstract] AND IFNAR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFNAR2

GO:0035455

response to interferon-alpha

7759950

TgeneIFNAR2

GO:0060337

type I interferon signaling pathway

7665574


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF848469NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000384994ENST00000382264NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000382241NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000404220NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000342136NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000420068NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000342101NEAT1chr11

65207789

-IFNAR2chr21

34609858

+
intron-intronENST00000384994ENST00000413881NEAT1chr11

65207789

-IFNAR2chr21

34609858

+

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FusionProtFeatures for NEAT1_IFNAR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEAT1

IFNAR2

P48551

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Associates with IFNAR1 to form the type I interferonreceptor. Receptor for interferons alpha and beta. Involved inIFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569).Isoform 1 and isoform 2 are directly involved in signaltransduction due to their association with the TYR kinase, JAK1(PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is apotent inhibitor of type I IFN receptor activity (PubMed:7759950).{ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:11682488,ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:26424569,ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950,ECO:0000269|PubMed:8181059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEAT1_IFNAR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEAT1_IFNAR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEAT1_IFNAR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIFNAR2P48551DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 2biotechapproved
TgeneIFNAR2P48551DB00068Interferon beta-1bInterferon alpha/beta receptor 2biotechapproved
TgeneIFNAR2P48551DB00105Interferon Alfa-2b, RecombinantInterferon alpha/beta receptor 2biotechapproved
TgeneIFNAR2P48551DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2biotechapproved|investigational
TgeneIFNAR2P48551DB00011Interferon alfa-n1Interferon alpha/beta receptor 2biotechapproved|investigational
TgeneIFNAR2P48551DB00034Interferon Alfa-2a, RecombinantInterferon alpha/beta receptor 2biotechapproved|investigational
TgeneIFNAR2P48551DB00060Interferon beta-1aInterferon alpha/beta receptor 2biotechapproved|investigational
TgeneIFNAR2P48551DB00069Interferon alfacon-1Interferon alpha/beta receptor 2biotechapproved|investigational

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RelatedDiseases for NEAT1_IFNAR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEAT1C0023903Liver neoplasms1CTD_human
HgeneNEAT1C3495559Juvenile arthritis1CTD_human