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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23900

FusionGeneSummary for NDUFV1_NDUFV1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFV1_NDUFV1
Fusion gene ID: 23900
HgeneTgene
Gene symbol

NDUFV1

NDUFV1

Gene ID

4723

4723

Gene nameNADH:ubiquinone oxidoreductase core subunit V1NADH:ubiquinone oxidoreductase core subunit V1
SynonymsCI-51K|CI51KD|UQOR1CI-51K|CI51KD|UQOR1
Cytomap

11q13.2

11q13.2

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainmNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainm
Modification date2018052320180523
UniProtAcc

P49821

P49821

Ensembl transtripts involved in fusion geneENST00000322776, ENST00000532303, 
ENST00000529927, ENST00000415352, 
ENST00000526169, 		ENST00000322776, 
ENST00000532303, ENST00000529927, 
ENST00000415352, ENST00000526169, 
Fusion gene scores* DoF score2 X 2 X 1=435 X 6 X 14=2940
# samples 237
** MAII scorelog2(2/4*10)=2.32192809488736log2(37/2940*10)=-2.99021897920741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFV1 [Title/Abstract] AND NDUFV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP193532NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000322776ENST00000322776NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000322776ENST00000532303NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000322776ENST00000529927NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000322776ENST00000415352NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-intronENST00000322776ENST00000526169NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000532303ENST00000322776NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000532303ENST00000532303NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000532303ENST00000529927NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000532303ENST00000415352NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-intronENST00000532303ENST00000526169NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000529927ENST00000322776NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000529927ENST00000532303NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000529927ENST00000529927NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000529927ENST00000415352NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-intronENST00000529927ENST00000526169NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000415352ENST00000322776NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000415352ENST00000532303NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000415352ENST00000529927NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-5UTRENST00000415352ENST00000415352NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
5CDS-intronENST00000415352ENST00000526169NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
3UTR-5UTRENST00000526169ENST00000322776NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
3UTR-5UTRENST00000526169ENST00000532303NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
3UTR-5UTRENST00000526169ENST00000529927NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
3UTR-5UTRENST00000526169ENST00000415352NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+
3UTR-intronENST00000526169ENST00000526169NDUFV1chr11

67377003

+NDUFV1chr11

67374411

+

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FusionProtFeatures for NDUFV1_NDUFV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFV1

P49821

NDUFV1

P49821

Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}. Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDUFV1_NDUFV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDUFV1_NDUFV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDUFV1_NDUFV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDUFV1_NDUFV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDUFV1C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY2CTD_human;UNIPROT
HgeneNDUFV1C0005586Bipolar Disorder1PSYGENET
HgeneNDUFV1C0023264Leigh Disease1CTD_human;ORPHANET;UNIPROT
HgeneNDUFV1C0029408Degenerative polyarthritis1CTD_human
HgeneNDUFV1C0036341Schizophrenia1PSYGENET
HgeneNDUFV1C0038356Stomach Neoplasms1CTD_human
HgeneNDUFV1C0041696Unipolar Depression1PSYGENET
HgeneNDUFV1C1269683Major Depressive Disorder1PSYGENET
TgeneNDUFV1C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY2CTD_human;UNIPROT
TgeneNDUFV1C0005586Bipolar Disorder1PSYGENET
TgeneNDUFV1C0023264Leigh Disease1CTD_human;ORPHANET;UNIPROT
TgeneNDUFV1C0029408Degenerative polyarthritis1CTD_human
TgeneNDUFV1C0036341Schizophrenia1PSYGENET
TgeneNDUFV1C0038356Stomach Neoplasms1CTD_human
TgeneNDUFV1C0041696Unipolar Depression1PSYGENET
TgeneNDUFV1C1269683Major Depressive Disorder1PSYGENET