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Fusion gene ID: 23894 |
FusionGeneSummary for NDUFS6_C7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFS6_C7 | Fusion gene ID: 23894 | Hgene | Tgene | Gene symbol | NDUFS6 | C7 | Gene ID | 4726 | 730 |
| Gene name | NADH:ubiquinone oxidoreductase subunit S6 | complement C7 | |
| Synonyms | CI-13kA|CI-13kD-A|CI13KDA | - | |
| Cytomap | 5p15.33 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 13 kDa-A subunitNADH:ubiquinone oxidoreductase NDUFS6 subunitcomplex I | complement component C7complement component 7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O75380 | P10643 | |
| Ensembl transtripts involved in fusion gene | ENST00000274137, ENST00000469176, ENST00000510329, | ENST00000313164, ENST00000494960, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 12 X 3 X 9=324 |
| # samples | 4 | 13 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/324*10)=-1.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDUFS6 [Title/Abstract] AND C7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-77-8153-01A | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000274137 | ENST00000313164 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| 5CDS-intron | ENST00000274137 | ENST00000494960 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| In-frame | ENST00000469176 | ENST00000313164 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| 5CDS-intron | ENST00000469176 | ENST00000494960 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| intron-3CDS | ENST00000510329 | ENST00000313164 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
| intron-intron | ENST00000510329 | ENST00000494960 | NDUFS6 | chr5 | 1802488 | + | C7 | chr5 | 40928682 | + |
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FusionProtFeatures for NDUFS6_C7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFS6 | C7 |
| Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. | Constituent of the membrane attack complex (MAC) thatplays a key role in the innate and adaptive immune response byforming pores in the plasma membrane of target cells. C7 serves asa membrane anchor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 124_456 | 2 | 844 | Domain | MACPF |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 27_80 | 2 | 844 | Domain | TSP type-1 1 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 457_487 | 2 | 844 | Domain | Note=EGF-like |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 500_549 | 2 | 844 | Domain | TSP type-1 2 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 569_628 | 2 | 844 | Domain | Sushi 1 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 629_690 | 2 | 844 | Domain | Sushi 2 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 83_121 | 2 | 844 | Domain | LDL-receptor class A |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 545_615 | 2 | 844 | Region | Note=CCP 1 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 616_693 | 2 | 844 | Region | Note=CCP 2 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 695_770 | 2 | 844 | Region | Note=Factor I module (FIM) 1 |
| Tgene | >C7 | chr5:1802488 | chr5:40928682 | ENST00000313164 | + | 0 | 18 | 771_843 | 2 | 844 | Region | Note=Factor I module (FIM) 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFS6_C7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NDUFS6_ENST00000274137_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_904aa MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVISLFILVGFIGEFQSFSSASSPVNCQW DFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKH TSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSY LELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEF CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPLTVCKMHVLHC QGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA >In-frame_NDUFS6_ENST00000469176_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_904aa MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVISLFILVGFIGEFQSFSSASSPVNCQW DFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKH TSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSY LELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEF CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPLTVCKMHVLHC QGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NDUFS6_ENST00000274137_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_2712nt ATGGCGGCGGCGATGACCTTCTGCCGGCTGCTGAACCGGTGTGGCGAGGCGGCGCGGAGCCTGCCCCTGGGCGCCAGGTGTTTCGGGGTG CGGGTCTCGCCGACCGGGGAGAAGGTCACGCACACTGGCCAGGTTTATGATGATAAAGACTACAGGAGAATTCGGTTTGTAGGTCGTCAG AAAGAGGTGATAAGCTTATTCATTTTGGTGGGATTTATAGGAGAGTTCCAAAGTTTTTCAAGTGCCTCCTCTCCAGTCAACTGCCAGTGG GACTTCTATGCCCCTTGGTCAGAATGCAATGGCTGTACCAAGACTCAGACTCGCAGGCGGTCAGTTGCTGTGTATGGGCAGTATGGAGGC CAGCCTTGTGTTGGAAATGCTTTTGAAACACAGTCCTGTGAACCTACAAGAGGATGTCCAACAGAGGAGGGATGTGGAGAGCGTTTCAGG TGCTTTTCAGGTCAGTGCATCAGCAAATCATTGGTTTGCAATGGGGATTCTGACTGTGATGAAGACAGTGCTGATGAAGACAGATGTGAG GACTCAGAAAGGAGACCTTCCTGTGATATCGATAAACCTCCTCCTAACATAGAACTTACTGGAAATGGTTACAATGAACTCACTGGCCAG TTTAGGAACAGAGTCATCAATACCAAAAGTTTTGGTGGTCAATGTAGAAAGGTGTTTAGTGGGGATGGAAAAGATTTCTACAGGCTGAGT GGAAATGTCCTGTCCTATACATTCCAGGTGAAAATAAATAATGATTTTAATTATGAATTTTACAATAGTACTTGGTCTTATGTAAAACAT ACGTCGACAGAACACACATCATCTAGTCGGAAGCGCTCCTTTTTTAGATCTTCATCATCTTCTTCACGCAGTTATACTTCACATACCAAT GAAATCCATAAAGGAAAGAGTTACCAACTGCTGGTTGTTGAGAACACTGTTGAAGTGGCTCAGTTCATTAATAACAATCCAGAATTTTTA CAACTTGCTGAGCCATTCTGGAAGGAGCTTTCCCACCTCCCCTCTCTGTATGACTACAGTGCCTACCGAAGATTAATCGACCAGTACGGG ACACATTATCTGCAATCTGGGTCGTTAGGAGGAGAATACAGAGTTCTATTTTATGTGGACTCAGAAAAATTAAAACAAAATGATTTTAAT TCAGTCGAAGAAAAGAAATGTAAATCCTCAGGTTGGCATTTTGTCGTTAAATTTTCAAGTCATGGATGCAAGGAACTGGAAAACGCTTTA AAAGCTGCTTCAGGAACCCAGAACAATGTATTGCGAGGAGAACCGTTCATCAGAGGGGGAGGTGCAGGCTTCATATCTGGCCTTAGTTAC CTAGAGCTGGACAATCCTGCTGGAAACAAAAGGCGATATTCTGCCTGGGCAGAATCTGTGACTAATCTTCCTCAAGTCATAAAACAAAAG CTGACACCTTTATATGAGCTGGTAAAGGAAGTACCTTGTGCCTCTGTGAAAAAACTATACCTGAAATGGGCTCTTGAAGAGTATCTGGAT GAATTTGACCCCTGTCATTGCCGGCCTTGTCAAAATGGTGGTTTGGCTACTGTTGAGGGGACCCATTGTCTGTGCCATTGCAAACCGTAC ACATTTGGTGCGGCGTGTGAGCAAGGAGTCCTCGTAGGGAATCAAGCAGGAGGGGTTGATGGAGGTTGGAGTTGCTGGTCCTCTTGGAGC CCCTGTGTCCAAGGGAAGAAAACAAGAAGCCGTGAATGCAATAACCCACCTCCCAGTGGGGGTGGGAGATCCTGCGTTGGAGAAACGACA GAAAGCACACAATGCGAAGATGAGGAGCTGGAGCACTTGAGGTTGCTTGAACCACATTGCTTTCCTTTGTCTTTGGTTCCAACAGAATTC TGTCCATCACCTCCTGCCTTGAAAGATGGATTTGTTCAAGATGAAGGTACAATGTTTCCTGTGGGGAAAAATGTAGTGTACACTTGCAAT GAAGGATACTCTCTTATTGGAAACCCAGTGGCCAGATGTGGAGAAGATTTACGGTGGCTTGTTGGGGAAATGCATTGTCAGAAAATTGCC TGTGTTCTACCTGTACTGATGGATGGCATACAGAGTCACCCCCAAAAACCTTTCTACACAGTTGGTGAGAAGGTGACTGTTTCCTGTTCA GGTGGCATGTCCTTAGAAGGTCCTTCAGCATTTCTCTGTGGCTCCAGCCTTAAGTGGAGTCCTGAGATGAAGAATGCCCGCTGTGTACAA AAAGAAAATCCGTTAACACAGGCAGTGCCTAAATGTCAGCGCTGGGAGAAACTGCAGAATTCAAGATGTGTTTGTAAAATGCCCTACGAA TGTGGACCTTCCTTGGATGTATGTGCTCAAGATGAGAGAAGCAAAAGGATACTGCCTCTGACAGTTTGCAAGATGCATGTTCTCCACTGT CAGGGTAGAAATTACACCCTTACTGGTAGGGACAGCTGTACTCTGCCTGCCTCAGCTGAGAAAGCTTGTGGTGCCTGCCCACTGTGGGGA AAATGTGATGCTGAGAGCAGCAAATGTGTCTGCCGAGAAGCATCGGAGTGCGAGGAAGAAGGGTTTAGCATTTGTGTGGAAGTGAACGGC AAGGAGCAGACGATGTCTGAGTGTGAGGCGGGCGCTCTGAGATGCAGAGGGCAGAGCATCTCTGTCACCAGCATAAGGCCTTGTGCTGCG >In-frame_NDUFS6_ENST00000469176_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_2712nt ATGGCGGCGGCGATGACCTTCTGCCGGCTGCTGAACCGGTGTGGCGAGGCGGCGCGGAGCCTGCCCCTGGGCGCCAGGTGTTTCGGGGTG CGGGTCTCGCCGACCGGGGAGAAGGTCACGCACACTGGCCAGGTTTATGATGATAAAGACTACAGGAGAATTCGGTTTGTAGGTCGTCAG AAAGAGGTGATAAGCTTATTCATTTTGGTGGGATTTATAGGAGAGTTCCAAAGTTTTTCAAGTGCCTCCTCTCCAGTCAACTGCCAGTGG GACTTCTATGCCCCTTGGTCAGAATGCAATGGCTGTACCAAGACTCAGACTCGCAGGCGGTCAGTTGCTGTGTATGGGCAGTATGGAGGC CAGCCTTGTGTTGGAAATGCTTTTGAAACACAGTCCTGTGAACCTACAAGAGGATGTCCAACAGAGGAGGGATGTGGAGAGCGTTTCAGG TGCTTTTCAGGTCAGTGCATCAGCAAATCATTGGTTTGCAATGGGGATTCTGACTGTGATGAAGACAGTGCTGATGAAGACAGATGTGAG GACTCAGAAAGGAGACCTTCCTGTGATATCGATAAACCTCCTCCTAACATAGAACTTACTGGAAATGGTTACAATGAACTCACTGGCCAG TTTAGGAACAGAGTCATCAATACCAAAAGTTTTGGTGGTCAATGTAGAAAGGTGTTTAGTGGGGATGGAAAAGATTTCTACAGGCTGAGT GGAAATGTCCTGTCCTATACATTCCAGGTGAAAATAAATAATGATTTTAATTATGAATTTTACAATAGTACTTGGTCTTATGTAAAACAT ACGTCGACAGAACACACATCATCTAGTCGGAAGCGCTCCTTTTTTAGATCTTCATCATCTTCTTCACGCAGTTATACTTCACATACCAAT GAAATCCATAAAGGAAAGAGTTACCAACTGCTGGTTGTTGAGAACACTGTTGAAGTGGCTCAGTTCATTAATAACAATCCAGAATTTTTA CAACTTGCTGAGCCATTCTGGAAGGAGCTTTCCCACCTCCCCTCTCTGTATGACTACAGTGCCTACCGAAGATTAATCGACCAGTACGGG ACACATTATCTGCAATCTGGGTCGTTAGGAGGAGAATACAGAGTTCTATTTTATGTGGACTCAGAAAAATTAAAACAAAATGATTTTAAT TCAGTCGAAGAAAAGAAATGTAAATCCTCAGGTTGGCATTTTGTCGTTAAATTTTCAAGTCATGGATGCAAGGAACTGGAAAACGCTTTA AAAGCTGCTTCAGGAACCCAGAACAATGTATTGCGAGGAGAACCGTTCATCAGAGGGGGAGGTGCAGGCTTCATATCTGGCCTTAGTTAC CTAGAGCTGGACAATCCTGCTGGAAACAAAAGGCGATATTCTGCCTGGGCAGAATCTGTGACTAATCTTCCTCAAGTCATAAAACAAAAG CTGACACCTTTATATGAGCTGGTAAAGGAAGTACCTTGTGCCTCTGTGAAAAAACTATACCTGAAATGGGCTCTTGAAGAGTATCTGGAT GAATTTGACCCCTGTCATTGCCGGCCTTGTCAAAATGGTGGTTTGGCTACTGTTGAGGGGACCCATTGTCTGTGCCATTGCAAACCGTAC ACATTTGGTGCGGCGTGTGAGCAAGGAGTCCTCGTAGGGAATCAAGCAGGAGGGGTTGATGGAGGTTGGAGTTGCTGGTCCTCTTGGAGC CCCTGTGTCCAAGGGAAGAAAACAAGAAGCCGTGAATGCAATAACCCACCTCCCAGTGGGGGTGGGAGATCCTGCGTTGGAGAAACGACA GAAAGCACACAATGCGAAGATGAGGAGCTGGAGCACTTGAGGTTGCTTGAACCACATTGCTTTCCTTTGTCTTTGGTTCCAACAGAATTC TGTCCATCACCTCCTGCCTTGAAAGATGGATTTGTTCAAGATGAAGGTACAATGTTTCCTGTGGGGAAAAATGTAGTGTACACTTGCAAT GAAGGATACTCTCTTATTGGAAACCCAGTGGCCAGATGTGGAGAAGATTTACGGTGGCTTGTTGGGGAAATGCATTGTCAGAAAATTGCC TGTGTTCTACCTGTACTGATGGATGGCATACAGAGTCACCCCCAAAAACCTTTCTACACAGTTGGTGAGAAGGTGACTGTTTCCTGTTCA GGTGGCATGTCCTTAGAAGGTCCTTCAGCATTTCTCTGTGGCTCCAGCCTTAAGTGGAGTCCTGAGATGAAGAATGCCCGCTGTGTACAA AAAGAAAATCCGTTAACACAGGCAGTGCCTAAATGTCAGCGCTGGGAGAAACTGCAGAATTCAAGATGTGTTTGTAAAATGCCCTACGAA TGTGGACCTTCCTTGGATGTATGTGCTCAAGATGAGAGAAGCAAAAGGATACTGCCTCTGACAGTTTGCAAGATGCATGTTCTCCACTGT CAGGGTAGAAATTACACCCTTACTGGTAGGGACAGCTGTACTCTGCCTGCCTCAGCTGAGAAAGCTTGTGGTGCCTGCCCACTGTGGGGA AAATGTGATGCTGAGAGCAGCAAATGTGTCTGCCGAGAAGCATCGGAGTGCGAGGAAGAAGGGTTTAGCATTTGTGTGGAAGTGAACGGC AAGGAGCAGACGATGTCTGAGTGTGAGGCGGGCGCTCTGAGATGCAGAGGGCAGAGCATCTCTGTCACCAGCATAAGGCCTTGTGCTGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NDUFS6_ENST00000274137_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_4096nt AAAGGCCAGCGGCGCAAAATGGCGGCGGCGATGACCTTCTGCCGGCTGCTGAACCGGTGTGGCGAGGCGGCGCGGAGCCTGCCCCTGGGC GCCAGGTGTTTCGGGGTGCGGGTCTCGCCGACCGGGGAGAAGGTCACGCACACTGGCCAGGTTTATGATGATAAAGACTACAGGAGAATT CGGTTTGTAGGTCGTCAGAAAGAGGTGATAAGCTTATTCATTTTGGTGGGATTTATAGGAGAGTTCCAAAGTTTTTCAAGTGCCTCCTCT CCAGTCAACTGCCAGTGGGACTTCTATGCCCCTTGGTCAGAATGCAATGGCTGTACCAAGACTCAGACTCGCAGGCGGTCAGTTGCTGTG TATGGGCAGTATGGAGGCCAGCCTTGTGTTGGAAATGCTTTTGAAACACAGTCCTGTGAACCTACAAGAGGATGTCCAACAGAGGAGGGA TGTGGAGAGCGTTTCAGGTGCTTTTCAGGTCAGTGCATCAGCAAATCATTGGTTTGCAATGGGGATTCTGACTGTGATGAAGACAGTGCT GATGAAGACAGATGTGAGGACTCAGAAAGGAGACCTTCCTGTGATATCGATAAACCTCCTCCTAACATAGAACTTACTGGAAATGGTTAC AATGAACTCACTGGCCAGTTTAGGAACAGAGTCATCAATACCAAAAGTTTTGGTGGTCAATGTAGAAAGGTGTTTAGTGGGGATGGAAAA GATTTCTACAGGCTGAGTGGAAATGTCCTGTCCTATACATTCCAGGTGAAAATAAATAATGATTTTAATTATGAATTTTACAATAGTACT TGGTCTTATGTAAAACATACGTCGACAGAACACACATCATCTAGTCGGAAGCGCTCCTTTTTTAGATCTTCATCATCTTCTTCACGCAGT TATACTTCACATACCAATGAAATCCATAAAGGAAAGAGTTACCAACTGCTGGTTGTTGAGAACACTGTTGAAGTGGCTCAGTTCATTAAT AACAATCCAGAATTTTTACAACTTGCTGAGCCATTCTGGAAGGAGCTTTCCCACCTCCCCTCTCTGTATGACTACAGTGCCTACCGAAGA TTAATCGACCAGTACGGGACACATTATCTGCAATCTGGGTCGTTAGGAGGAGAATACAGAGTTCTATTTTATGTGGACTCAGAAAAATTA AAACAAAATGATTTTAATTCAGTCGAAGAAAAGAAATGTAAATCCTCAGGTTGGCATTTTGTCGTTAAATTTTCAAGTCATGGATGCAAG GAACTGGAAAACGCTTTAAAAGCTGCTTCAGGAACCCAGAACAATGTATTGCGAGGAGAACCGTTCATCAGAGGGGGAGGTGCAGGCTTC ATATCTGGCCTTAGTTACCTAGAGCTGGACAATCCTGCTGGAAACAAAAGGCGATATTCTGCCTGGGCAGAATCTGTGACTAATCTTCCT CAAGTCATAAAACAAAAGCTGACACCTTTATATGAGCTGGTAAAGGAAGTACCTTGTGCCTCTGTGAAAAAACTATACCTGAAATGGGCT CTTGAAGAGTATCTGGATGAATTTGACCCCTGTCATTGCCGGCCTTGTCAAAATGGTGGTTTGGCTACTGTTGAGGGGACCCATTGTCTG TGCCATTGCAAACCGTACACATTTGGTGCGGCGTGTGAGCAAGGAGTCCTCGTAGGGAATCAAGCAGGAGGGGTTGATGGAGGTTGGAGT TGCTGGTCCTCTTGGAGCCCCTGTGTCCAAGGGAAGAAAACAAGAAGCCGTGAATGCAATAACCCACCTCCCAGTGGGGGTGGGAGATCC TGCGTTGGAGAAACGACAGAAAGCACACAATGCGAAGATGAGGAGCTGGAGCACTTGAGGTTGCTTGAACCACATTGCTTTCCTTTGTCT TTGGTTCCAACAGAATTCTGTCCATCACCTCCTGCCTTGAAAGATGGATTTGTTCAAGATGAAGGTACAATGTTTCCTGTGGGGAAAAAT GTAGTGTACACTTGCAATGAAGGATACTCTCTTATTGGAAACCCAGTGGCCAGATGTGGAGAAGATTTACGGTGGCTTGTTGGGGAAATG CATTGTCAGAAAATTGCCTGTGTTCTACCTGTACTGATGGATGGCATACAGAGTCACCCCCAAAAACCTTTCTACACAGTTGGTGAGAAG GTGACTGTTTCCTGTTCAGGTGGCATGTCCTTAGAAGGTCCTTCAGCATTTCTCTGTGGCTCCAGCCTTAAGTGGAGTCCTGAGATGAAG AATGCCCGCTGTGTACAAAAAGAAAATCCGTTAACACAGGCAGTGCCTAAATGTCAGCGCTGGGAGAAACTGCAGAATTCAAGATGTGTT TGTAAAATGCCCTACGAATGTGGACCTTCCTTGGATGTATGTGCTCAAGATGAGAGAAGCAAAAGGATACTGCCTCTGACAGTTTGCAAG ATGCATGTTCTCCACTGTCAGGGTAGAAATTACACCCTTACTGGTAGGGACAGCTGTACTCTGCCTGCCTCAGCTGAGAAAGCTTGTGGT GCCTGCCCACTGTGGGGAAAATGTGATGCTGAGAGCAGCAAATGTGTCTGCCGAGAAGCATCGGAGTGCGAGGAAGAAGGGTTTAGCATT TGTGTGGAAGTGAACGGCAAGGAGCAGACGATGTCTGAGTGTGAGGCGGGCGCTCTGAGATGCAGAGGGCAGAGCATCTCTGTCACCAGC ATAAGGCCTTGTGCTGCGGAAACCCAGTAGGCTCCTGGAGGCCCTGGTCAGCTTGCTTGGAATCCAGCAGGCAGCTGGGGCTGAGTGAAA ACATCTGCACAACTGGGCACTGGACAGCTTTTCCTTCTTCTCCAGTGTCTACCTTCCTCCTCAACTCCCAGCCATCTGTATAAACACAAT CCTTTGTTCTCCCAAATCTGAATCGAATTACTCTTTTGCCTCCTTTTTAATGTCAGTAAGGATATGAGCCTTTGCACAGGCTGGCTGCGT GTTCTTGAAATAGGTGTTACCTTCTCTGGGCCTTGGTTTTTTAAAATCTGTAAAATTAGAGGATTGCACTAGAGAAACTTGAATGCTCCA TTCAGGCCTATCATTTTATTAAGTATGATTGACACAGCCCATGGGCCAGAACACACTCTACAAAATGACTAGGATAACAGAAAGAACGTG ATCTCCTGATTAGAGAGGGTGGTTTTCCTCAATGGAACCAAATATAAAGAGGACTTGAACAAAAATGACAGATACAAACTATTTCTATCC TGAGTAGTAATCTCACACTTCATCCTATAGAGTCAACCACCACAGATAGGAATTCCTTATTCTTTTTTTAATTTTTTTAAGACAGAGTCT CACTTTGTTGCCCAGGCTGGAGCGCAGTGGGGTGATCTCATCTCCCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTTGTGCCTCAGC TTCCCAAGCAGCTGGGATTACAGGTGCCCGCCACCACGCCCAGCTAATTTTTGCATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCA CGCTCGTCTCCAACTCCTGACCTCAGGTAATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACATGAACCACCACGCCTGGCT GGAATACTTACTCTTGTCGGGAGATTGAACCACTAAAATGTTAGAGCAGAATTCATTATGCTGTGGTCACAGGGGTGTCTTGTCTGAGAA CAAATACAATTCAGTCTTCTCTTTGGGGTTTTAGTATGTGTCAAACATAGGACTGGAAGTTTGCCCCTGTTCTTTTTTCTTTTGAAAGAA CATCAGTTCATGCCTGAGGCATGAGTGACTGTGCATTTGAGAATAGTTTTCCCTATTCTGTGGATACAGTCCCAGAGTTTTCAGGGAGTA CACAGGTAGATTAGTTTGAAGCATTGACCTTTTATTTATTCCTTATTTCTCTTTCATCAAAACAAAACAGCAGCTGTGGGAGGAGAAATG AGAGGGCTTAAATGAAATTTAAAATAAGCTATATTATACAAATACTATCTCTGTATTGTTCTGACCCTGGTAAATATATTTCAAAACTTC >In-frame_NDUFS6_ENST00000469176_chr5_1802488_+_C7_ENST00000313164_chr5_40928682_+_4081nt AAAATGGCGGCGGCGATGACCTTCTGCCGGCTGCTGAACCGGTGTGGCGAGGCGGCGCGGAGCCTGCCCCTGGGCGCCAGGTGTTTCGGG GTGCGGGTCTCGCCGACCGGGGAGAAGGTCACGCACACTGGCCAGGTTTATGATGATAAAGACTACAGGAGAATTCGGTTTGTAGGTCGT CAGAAAGAGGTGATAAGCTTATTCATTTTGGTGGGATTTATAGGAGAGTTCCAAAGTTTTTCAAGTGCCTCCTCTCCAGTCAACTGCCAG TGGGACTTCTATGCCCCTTGGTCAGAATGCAATGGCTGTACCAAGACTCAGACTCGCAGGCGGTCAGTTGCTGTGTATGGGCAGTATGGA GGCCAGCCTTGTGTTGGAAATGCTTTTGAAACACAGTCCTGTGAACCTACAAGAGGATGTCCAACAGAGGAGGGATGTGGAGAGCGTTTC AGGTGCTTTTCAGGTCAGTGCATCAGCAAATCATTGGTTTGCAATGGGGATTCTGACTGTGATGAAGACAGTGCTGATGAAGACAGATGT GAGGACTCAGAAAGGAGACCTTCCTGTGATATCGATAAACCTCCTCCTAACATAGAACTTACTGGAAATGGTTACAATGAACTCACTGGC CAGTTTAGGAACAGAGTCATCAATACCAAAAGTTTTGGTGGTCAATGTAGAAAGGTGTTTAGTGGGGATGGAAAAGATTTCTACAGGCTG AGTGGAAATGTCCTGTCCTATACATTCCAGGTGAAAATAAATAATGATTTTAATTATGAATTTTACAATAGTACTTGGTCTTATGTAAAA CATACGTCGACAGAACACACATCATCTAGTCGGAAGCGCTCCTTTTTTAGATCTTCATCATCTTCTTCACGCAGTTATACTTCACATACC AATGAAATCCATAAAGGAAAGAGTTACCAACTGCTGGTTGTTGAGAACACTGTTGAAGTGGCTCAGTTCATTAATAACAATCCAGAATTT TTACAACTTGCTGAGCCATTCTGGAAGGAGCTTTCCCACCTCCCCTCTCTGTATGACTACAGTGCCTACCGAAGATTAATCGACCAGTAC GGGACACATTATCTGCAATCTGGGTCGTTAGGAGGAGAATACAGAGTTCTATTTTATGTGGACTCAGAAAAATTAAAACAAAATGATTTT AATTCAGTCGAAGAAAAGAAATGTAAATCCTCAGGTTGGCATTTTGTCGTTAAATTTTCAAGTCATGGATGCAAGGAACTGGAAAACGCT TTAAAAGCTGCTTCAGGAACCCAGAACAATGTATTGCGAGGAGAACCGTTCATCAGAGGGGGAGGTGCAGGCTTCATATCTGGCCTTAGT TACCTAGAGCTGGACAATCCTGCTGGAAACAAAAGGCGATATTCTGCCTGGGCAGAATCTGTGACTAATCTTCCTCAAGTCATAAAACAA AAGCTGACACCTTTATATGAGCTGGTAAAGGAAGTACCTTGTGCCTCTGTGAAAAAACTATACCTGAAATGGGCTCTTGAAGAGTATCTG GATGAATTTGACCCCTGTCATTGCCGGCCTTGTCAAAATGGTGGTTTGGCTACTGTTGAGGGGACCCATTGTCTGTGCCATTGCAAACCG TACACATTTGGTGCGGCGTGTGAGCAAGGAGTCCTCGTAGGGAATCAAGCAGGAGGGGTTGATGGAGGTTGGAGTTGCTGGTCCTCTTGG AGCCCCTGTGTCCAAGGGAAGAAAACAAGAAGCCGTGAATGCAATAACCCACCTCCCAGTGGGGGTGGGAGATCCTGCGTTGGAGAAACG ACAGAAAGCACACAATGCGAAGATGAGGAGCTGGAGCACTTGAGGTTGCTTGAACCACATTGCTTTCCTTTGTCTTTGGTTCCAACAGAA TTCTGTCCATCACCTCCTGCCTTGAAAGATGGATTTGTTCAAGATGAAGGTACAATGTTTCCTGTGGGGAAAAATGTAGTGTACACTTGC AATGAAGGATACTCTCTTATTGGAAACCCAGTGGCCAGATGTGGAGAAGATTTACGGTGGCTTGTTGGGGAAATGCATTGTCAGAAAATT GCCTGTGTTCTACCTGTACTGATGGATGGCATACAGAGTCACCCCCAAAAACCTTTCTACACAGTTGGTGAGAAGGTGACTGTTTCCTGT TCAGGTGGCATGTCCTTAGAAGGTCCTTCAGCATTTCTCTGTGGCTCCAGCCTTAAGTGGAGTCCTGAGATGAAGAATGCCCGCTGTGTA CAAAAAGAAAATCCGTTAACACAGGCAGTGCCTAAATGTCAGCGCTGGGAGAAACTGCAGAATTCAAGATGTGTTTGTAAAATGCCCTAC GAATGTGGACCTTCCTTGGATGTATGTGCTCAAGATGAGAGAAGCAAAAGGATACTGCCTCTGACAGTTTGCAAGATGCATGTTCTCCAC TGTCAGGGTAGAAATTACACCCTTACTGGTAGGGACAGCTGTACTCTGCCTGCCTCAGCTGAGAAAGCTTGTGGTGCCTGCCCACTGTGG GGAAAATGTGATGCTGAGAGCAGCAAATGTGTCTGCCGAGAAGCATCGGAGTGCGAGGAAGAAGGGTTTAGCATTTGTGTGGAAGTGAAC GGCAAGGAGCAGACGATGTCTGAGTGTGAGGCGGGCGCTCTGAGATGCAGAGGGCAGAGCATCTCTGTCACCAGCATAAGGCCTTGTGCT GCGGAAACCCAGTAGGCTCCTGGAGGCCCTGGTCAGCTTGCTTGGAATCCAGCAGGCAGCTGGGGCTGAGTGAAAACATCTGCACAACTG GGCACTGGACAGCTTTTCCTTCTTCTCCAGTGTCTACCTTCCTCCTCAACTCCCAGCCATCTGTATAAACACAATCCTTTGTTCTCCCAA ATCTGAATCGAATTACTCTTTTGCCTCCTTTTTAATGTCAGTAAGGATATGAGCCTTTGCACAGGCTGGCTGCGTGTTCTTGAAATAGGT GTTACCTTCTCTGGGCCTTGGTTTTTTAAAATCTGTAAAATTAGAGGATTGCACTAGAGAAACTTGAATGCTCCATTCAGGCCTATCATT TTATTAAGTATGATTGACACAGCCCATGGGCCAGAACACACTCTACAAAATGACTAGGATAACAGAAAGAACGTGATCTCCTGATTAGAG AGGGTGGTTTTCCTCAATGGAACCAAATATAAAGAGGACTTGAACAAAAATGACAGATACAAACTATTTCTATCCTGAGTAGTAATCTCA CACTTCATCCTATAGAGTCAACCACCACAGATAGGAATTCCTTATTCTTTTTTTAATTTTTTTAAGACAGAGTCTCACTTTGTTGCCCAG GCTGGAGCGCAGTGGGGTGATCTCATCTCCCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTTGTGCCTCAGCTTCCCAAGCAGCTGG GATTACAGGTGCCCGCCACCACGCCCAGCTAATTTTTGCATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCACGCTCGTCTCCAACT CCTGACCTCAGGTAATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACATGAACCACCACGCCTGGCTGGAATACTTACTCTT GTCGGGAGATTGAACCACTAAAATGTTAGAGCAGAATTCATTATGCTGTGGTCACAGGGGTGTCTTGTCTGAGAACAAATACAATTCAGT CTTCTCTTTGGGGTTTTAGTATGTGTCAAACATAGGACTGGAAGTTTGCCCCTGTTCTTTTTTCTTTTGAAAGAACATCAGTTCATGCCT GAGGCATGAGTGACTGTGCATTTGAGAATAGTTTTCCCTATTCTGTGGATACAGTCCCAGAGTTTTCAGGGAGTACACAGGTAGATTAGT TTGAAGCATTGACCTTTTATTTATTCCTTATTTCTCTTTCATCAAAACAAAACAGCAGCTGTGGGAGGAGAAATGAGAGGGCTTAAATGA AATTTAAAATAAGCTATATTATACAAATACTATCTCTGTATTGTTCTGACCCTGGTAAATATATTTCAAAACTTCAGATGACAAGGATTA |
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FusionGenePPI for NDUFS6_C7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDUFS6 | FGFR3, KCNH2, MAPK8IP2, MAP3K7, MAPK6, NDUFA2, NDUFS4, NDUFB4, NDUFS2, NDUFS7, NDUFS8, OR4S2, TJP1, NEDD8, FLOT1, NNT, TMEM65, SEPT11, ILF3, SDHA, RPS12, RALA, COX15, MPV17, MOV10, NXF1, NDUFS3, FBXO17, ECHDC2, LIG3, FGL1, DTX3, GCAT, NDUFA8, NDUFA12, NDUFS5, NDUFA9, NDUFA11, NDUFV3, NDUFS1, NDUFV2, NDUFA7, NDUFV1, ND4, RAB7A, VAPA, GOLT1B, MMGT1, BOLA3, NDUFA4, C15orf48, COX6B1, FAM136A, NDUFB7, ND5, NDUFB6, NDUFC2, NDUFB8, NDUFB3, NDUFB1, NDUFB5, NDUFB9, ND1, NDUFB11, FAHD1, ND2, BCAT2, DNAJC30, TACR1, NDUFA13, GALNT6, ALAS1, RMND5A, ARMC8, GID4, NDUFA6, GDPD5, RNMTL1, GID8, VAPB, METTL2A, NDUFA1, ZMYND19, NDUFA3, NDUFB10, NDUFAB1, TRMT1, PCK2, RANBP10, ILKAP, RASL10B, PDHA1 | C7 | C5, CLU, PLG, NTRK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFS6_C7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFS6_C7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C7 | C1864694 | Complement Component 7 Deficiency | 3 | CTD_human;UNIPROT |
| Tgene | C7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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