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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23882

FusionGeneSummary for NDUFS3_NDUFS3

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFS3_NDUFS3
Fusion gene ID: 23882
HgeneTgene
Gene symbol

NDUFS3

NDUFS3

Gene ID

4722

4722

Gene nameNADH:ubiquinone oxidoreductase core subunit S3NADH:ubiquinone oxidoreductase core subunit S3
SynonymsCI-30CI-30
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialCI-30kDNADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)NADH dehydrogenase-ubiquinone 30 kDa subunitNADH-ubiquinone oxidoreductase 30 kDa subunitcomplNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialCI-30kDNADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)NADH dehydrogenase-ubiquinone 30 kDa subunitNADH-ubiquinone oxidoreductase 30 kDa subunitcompl
Modification date2018052320180523
UniProtAcc

O75489

O75489

Ensembl transtripts involved in fusion geneENST00000533507, ENST00000263774, 
ENST00000529276, ENST00000528192, 
ENST00000534208, ENST00000534716, 
ENST00000533507, ENST00000263774, 
ENST00000529276, ENST00000528192, 
ENST00000534208, ENST00000534716, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 4 X 2=32
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDUFS3 [Title/Abstract] AND NDUFS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA450349NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000533507ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-3UTRENST00000533507ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000533507ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000533507ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000533507ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000533507ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-3UTRENST00000263774ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-3UTRENST00000263774ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000263774ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000263774ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000263774ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
3UTR-intronENST00000263774ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000529276ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000529276ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000529276ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000529276ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000529276ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000529276ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000528192ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000528192ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000528192ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000528192ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000528192ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000528192ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000534208ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000534208ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534208ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534208ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534208ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534208ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000534716ENST00000533507NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-3UTRENST00000534716ENST00000263774NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534716ENST00000529276NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534716ENST00000528192NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534716ENST00000534208NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+
intron-intronENST00000534716ENST00000534716NDUFS3chr11

47606039

-NDUFS3chr11

47605959

+

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FusionProtFeatures for NDUFS3_NDUFS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFS3

O75489

NDUFS3

O75489

Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}. Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDUFS3_NDUFS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDUFS3_NDUFS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDUFS3_NDUFS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDUFS3_NDUFS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDUFS3C0023264Leigh Disease1CTD_human;ORPHANET
HgeneNDUFS3C0029124Optic Atrophy1CTD_human;HPO
HgeneNDUFS3C1458155Mammary Neoplasms1CTD_human
TgeneNDUFS3C0023264Leigh Disease1CTD_human;ORPHANET
TgeneNDUFS3C0029124Optic Atrophy1CTD_human;HPO
TgeneNDUFS3C1458155Mammary Neoplasms1CTD_human