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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2388

FusionGeneSummary for ARHGAP1_CKAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP1_CKAP5
Fusion gene ID: 2388
HgeneTgene
Gene symbol

ARHGAP1

CKAP5

Gene ID

392

9793

Gene nameRho GTPase activating protein 1cytoskeleton associated protein 5
SynonymsCDC42GAP|RHOGAP|RHOGAP1|p50rhoGAPCHTOG|MSPS|TOG|TOGp|ch-TOG
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 1CDC42 GTPase-activating proteinGTPase-activating protein rhoGAPGTPase-activating protein rhoOGAPGTPase-activating protein, Rho, 1rho-related small GTPase protein activatorrho-type GTPase-activating protein 1cytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene protein
Modification date2018052220180523
UniProtAcc

Q07960

Q14008

Ensembl transtripts involved in fusion geneENST00000311956, ENST00000529230, 
ENST00000415402, ENST00000312055, 
ENST00000354558, ENST00000532321, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 8 X 5=320
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP1 [Title/Abstract] AND CKAP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP1

GO:0007264

small GTPase mediated signal transduction

8253717|8288572


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-A452-01AARHGAP1chr11

46709723

-CKAP5chr11

46792532

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000311956ENST00000529230ARHGAP1chr11

46709723

-CKAP5chr11

46792532

-
In-frameENST00000311956ENST00000415402ARHGAP1chr11

46709723

-CKAP5chr11

46792532

-
In-frameENST00000311956ENST00000312055ARHGAP1chr11

46709723

-CKAP5chr11

46792532

-
In-frameENST00000311956ENST00000354558ARHGAP1chr11

46709723

-CKAP5chr11

46792532

-
5CDS-intronENST00000311956ENST00000532321ARHGAP1chr11

46709723

-CKAP5chr11

46792532

-

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FusionProtFeatures for ARHGAP1_CKAP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP1

Q07960

CKAP5

Q14008

GTPase activator for the Rho, Rac and Cdc42 proteins,converting them to the putatively inactive GDP-bound state. Cdc42seems to be the preferred substrate. Binds to the plus end of microtubules and regulatesmicrotubule dynamics and microtubule organization. Acts asprocessive microtubule polymerase. Promotes cytoplasmicmicrotubule nucleation and elongation. Plays a major role inorganizing spindle poles. In spindle formation protectskinetochore microtubules from depolymerization by KIF2C and has anessential role in centrosomal microtubule assembly independentlyof KIF2C activity. Contributes to centrosome integrity. Acts ascomponent of the TACC3/ch-TOG/clathrin complex proposed tocontribute to stabilization of kinetochore fibers of the mitoticspindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance ofkinetochore fiber tension (PubMed:23532825). Enhances the strengthof NDC80 complex-mediated kinetochore-tip microtubule attachments(PubMed:27156448). {ECO:0000269|PubMed:12569123,ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582,ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825,ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431193_14289971973RegionTOG 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421193_14289971973RegionTOG 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441193_14289972040RegionTOG 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441193_14289972033RegionTOG 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431013_10519971973RepeatNote=HEAT 7
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431284_13229971973RepeatNote=HEAT 8
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431324_13579971973RepeatNote=HEAT 9
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431361_13999971973RepeatNote=HEAT 10
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421013_10519971973RepeatNote=HEAT 7
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421284_13229971973RepeatNote=HEAT 8
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421324_13579971973RepeatNote=HEAT 9
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421361_13999971973RepeatNote=HEAT 10
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441013_10519972040RepeatNote=HEAT 7
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441284_13229972040RepeatNote=HEAT 8
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441324_13579972040RepeatNote=HEAT 9
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441361_13999972040RepeatNote=HEAT 10
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441013_10519972033RepeatNote=HEAT 7
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441284_13229972033RepeatNote=HEAT 8
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441324_13579972033RepeatNote=HEAT 9
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441361_13999972033RepeatNote=HEAT 10

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP1chr11:46709723chr11:46792532ENST00000311956-413244_431105440DomainRho-GAP
HgeneARHGAP1chr11:46709723chr11:46792532ENST00000311956-41363_218105440DomainCRAL-TRIO
HgeneARHGAP1chr11:46709723chr11:46792532ENST00000311956-413228_238105440MotifNote=SH3-binding
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431_2239971973RegionTOG 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343268_5029971973RegionTOG 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343588_8179971973RegionTOG 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343853_10819971973RegionTOG 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421_2239971973RegionTOG 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242268_5029971973RegionTOG 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242588_8179971973RegionTOG 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242853_10819971973RegionTOG 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441_2239972040RegionTOG 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344268_5029972040RegionTOG 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344588_8179972040RegionTOG 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344853_10819972040RegionTOG 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441_2239972033RegionTOG 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344268_5029972033RegionTOG 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344588_8179972033RegionTOG 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344853_10819972033RegionTOG 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343159_1979971973RepeatNote=HEAT 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343356_3949971973RepeatNote=HEAT 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343434_4729971973RepeatNote=HEAT 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343750_7889971973RepeatNote=HEAT 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343855_8939971973RepeatNote=HEAT 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-2343936_9749971973RepeatNote=HEAT 6
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242159_1979971973RepeatNote=HEAT 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242356_3949971973RepeatNote=HEAT 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242434_4729971973RepeatNote=HEAT 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242750_7889971973RepeatNote=HEAT 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242855_8939971973RepeatNote=HEAT 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-2242936_9749971973RepeatNote=HEAT 6
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344159_1979972040RepeatNote=HEAT 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344356_3949972040RepeatNote=HEAT 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344434_4729972040RepeatNote=HEAT 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344750_7889972040RepeatNote=HEAT 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344855_8939972040RepeatNote=HEAT 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-2344936_9749972040RepeatNote=HEAT 6
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344159_1979972033RepeatNote=HEAT 1
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344356_3949972033RepeatNote=HEAT 2
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344434_4729972033RepeatNote=HEAT 3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344750_7889972033RepeatNote=HEAT 4
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344855_8939972033RepeatNote=HEAT 5
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-2344936_9749972033RepeatNote=HEAT 6


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FusionGeneSequence for ARHGAP1_CKAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP1_CKAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP1RHOC, RHOA, BNIPL, ARHGAP1, BNIP2, CDC42, SRC, PIK3R1, RAC1, SOX2, CHEK2, EGFR, FBXO25, FOXR2, FSD1, AP1B1, CAPZA1, CCDC22, FTH1, IRF2BP1, LARS, NMD3, PFKP, PPAT, TCEB1, UBA1, GFPT1, RUVBL2, TCTN2, TMEM17, TMEM216, AGTRAP, XPO1, CDH1, PPM1H, CDK15, FGB, SETX, MTNR1B, TRIM25, TESCKAP5TACC1, MEPCE, CDK9, CACNA1A, CKAP5, SLAIN2, SNW1, TACC3, TACC2, PTPRN2, SIRT7, TFAP4, USP21, GRK5, TOP1, FN1, USP19, BAG3, FBXO6, SHFM1, RPA3, RPA2, RPA1, HAUS2, CCDC8, EED, AUP1, KLHL20, SPINT2, LYPD3, CYP1A1, UNK, DHX29, EIF2D, ELAC2, HARS, SRCIN1, ZNHIT2, INTS2, MAPRE1, MAPRE3, NTRK1, IFI16, BTRC, MED4, CLK1, CEP162, CEP128, CNTRL, NINL, AHSA1, ACADVL, XIAP, DHCR24, H3F3A, HSPA5, LDHA, LDHB, MAPT, PFKM, MRPS12, RPS16, RPS17, TAP2, TOP2A, ZNHIT3, AKAP1, INTS7, ACAD8, TRMT6, KLHL7, DDX31, DOT1L, PRKCDBP, CCNYL1, PTRF, FOXL1, NF2, CDC5L, NDC80, CDH1, POTEB3, ALOX5, EPHA1, TMEM206, SDC2, KLHL40, KIAA1467, HSPA8, CEP83, SNRNP27, HSPA9, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCKAP5chr11:46709723chr11:46792532ENST00000312055-23431932_19579971973TACC3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000354558-22421932_19579971973TACC3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000415402-23441932_19579972040TACC3
TgeneCKAP5chr11:46709723chr11:46792532ENST00000529230-23441932_19579972033TACC3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP1_CKAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP1_CKAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP1C0036341Schizophrenia1PSYGENET
TgeneCKAP5C0002938Aneuploidy1CTD_human
TgeneCKAP5C1257806Chromosomal Instability1CTD_human