FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 2385

FusionGeneSummary for ARHGAP19_CYB5A

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP19_CYB5A
Fusion gene ID: 2385
HgeneTgene
Gene symbol

ARHGAP19

CYB5A

Gene ID

84986

1528

Gene nameRho GTPase activating protein 19cytochrome b5 type A
Synonyms-CYB5|MCB5|METAG
Cytomap

10q24.1

18q22.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 19putative RhoGAP proteinrho-type GTPase-activating protein 19cytochrome b5cytochrome b5 type A (microsomal)type 1 cyt-b5
Modification date2018052320180519
UniProtAcc

Q14CB8

P00167

Ensembl transtripts involved in fusion geneENST00000355366, ENST00000358531, 
ENST00000487035, ENST00000371027, 
ENST00000340533, ENST00000494131, 
ENST00000397914, ENST00000299438, 
ENST00000579064, 
Fusion gene scores* DoF score2 X 3 X 3=183 X 3 X 4=36
# samples 45
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP19 [Title/Abstract] AND CYB5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-AS-3777-01AARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
TCGARVLIHCTCGA-DD-A115-01AARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000355366ENST00000340533ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000355366ENST00000494131ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000355366ENST00000397914ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-5UTRENST00000355366ENST00000299438ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-intronENST00000355366ENST00000579064ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
In-frameENST00000358531ENST00000340533ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
In-frameENST00000358531ENST00000494131ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
In-frameENST00000358531ENST00000397914ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
5CDS-5UTRENST00000358531ENST00000299438ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
5CDS-intronENST00000358531ENST00000579064ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000487035ENST00000340533ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000487035ENST00000494131ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000487035ENST00000397914ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-5UTRENST00000487035ENST00000299438ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-intronENST00000487035ENST00000579064ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000371027ENST00000340533ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000371027ENST00000494131ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-3CDSENST00000371027ENST00000397914ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-5UTRENST00000371027ENST00000299438ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-
intron-intronENST00000371027ENST00000579064ARHGAP19chr10

99052329

-CYB5Achr18

71930712

-

Top

FusionProtFeatures for ARHGAP19_CYB5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP19

Q14CB8

CYB5A

P00167

Cytochrome b5 is a membrane bound hemoprotein whichfunction as an electron carrier for several membrane boundoxygenases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ARHGAP19_CYB5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_110aa
MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQMTDQSXTSLRKLLSLLLILVPVGGPTGX

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_18aa

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_100aa
MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQKLLSLLLILVPVGGPTGXSLPSLQWPSP

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_110aa
MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQMTDQSXTSLRKLLSLLLILVPVGGPTGX

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_18aa

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_100aa
MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQKLLSLLLILVPVGGPTGXSLPSLQWPSP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_332nt
ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG
CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC
ATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGA

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_56nt

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_302nt
ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG
CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC
ATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCT

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_332nt
ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG
CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC
ATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGA

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_56nt

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_302nt
ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG
CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC
ATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_649nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTC
TAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTG
AACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCT
TCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAA
TTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAAT

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_672nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAACCTTAAAGGCGGTGTTTCAAGGA
AACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTA
TCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCT
AACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAA
AGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTA

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_477nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGAT
CCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGA
GCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCT

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_649nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTC
TAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTG
AACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCT
TCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAA
TTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAAT

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_672nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAACCTTAAAGGCGGTGTTTCAAGGA
AACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTA
TCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCT
AACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAA
AGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTA

>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_477nt
GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC
TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT
GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGAT
CCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGA
GCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCT


Top

FusionGenePPI for ARHGAP19_CYB5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP19ELAVL1, ATXN3, LRRC47, RASA3, LYN, DEFA5, FHIT, IKZF5, DCAF16, RNF41, TDRKH, LRP2, ERBB2IP, CBY1CYB5ACYCS, UCHL5, CYP2E1, CYP2D6, CYP3A4, CYP2A6, CYP1A2, CYP4A11, UGT1A4, CYP2W1, FYTTD1, OR10H3, SOX2, SLC38A6, ISYNA1, ENDOD1, HSPA14, RABGAP1L, AGPAT4, TAB1, BCAP31, SNX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARHGAP19_CYB5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARHGAP19_CYB5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCYB5AC0014175Endometriosis1CTD_human
TgeneCYB5AC0028754Obesity1CTD_human
TgeneCYB5AC0035222Respiratory Distress Syndrome, Adult1CTD_human