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Fusion gene ID: 2385 |
FusionGeneSummary for ARHGAP19_CYB5A |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARHGAP19_CYB5A | Fusion gene ID: 2385 | Hgene | Tgene | Gene symbol | ARHGAP19 | CYB5A | Gene ID | 84986 | 1528 |
Gene name | Rho GTPase activating protein 19 | cytochrome b5 type A | |
Synonyms | - | CYB5|MCB5|METAG | |
Cytomap | 10q24.1 | 18q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | rho GTPase-activating protein 19putative RhoGAP proteinrho-type GTPase-activating protein 19 | cytochrome b5cytochrome b5 type A (microsomal)type 1 cyt-b5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q14CB8 | P00167 | |
Ensembl transtripts involved in fusion gene | ENST00000355366, ENST00000358531, ENST00000487035, ENST00000371027, | ENST00000340533, ENST00000494131, ENST00000397914, ENST00000299438, ENST00000579064, | |
Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 3 X 3 X 4=36 |
# samples | 4 | 5 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARHGAP19 [Title/Abstract] AND CYB5A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-AS-3777-01A | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
TCGA | RV | LIHC | TCGA-DD-A115-01A | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000355366 | ENST00000340533 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000355366 | ENST00000494131 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000355366 | ENST00000397914 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-5UTR | ENST00000355366 | ENST00000299438 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-intron | ENST00000355366 | ENST00000579064 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
In-frame | ENST00000358531 | ENST00000340533 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
In-frame | ENST00000358531 | ENST00000494131 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
In-frame | ENST00000358531 | ENST00000397914 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
5CDS-5UTR | ENST00000358531 | ENST00000299438 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
5CDS-intron | ENST00000358531 | ENST00000579064 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000487035 | ENST00000340533 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000487035 | ENST00000494131 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000487035 | ENST00000397914 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-5UTR | ENST00000487035 | ENST00000299438 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-intron | ENST00000487035 | ENST00000579064 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000371027 | ENST00000340533 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000371027 | ENST00000494131 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-3CDS | ENST00000371027 | ENST00000397914 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-5UTR | ENST00000371027 | ENST00000299438 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
intron-intron | ENST00000371027 | ENST00000579064 | ARHGAP19 | chr10 | 99052329 | - | CYB5A | chr18 | 71930712 | - |
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FusionProtFeatures for ARHGAP19_CYB5A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARHGAP19 | CYB5A |
Cytochrome b5 is a membrane bound hemoprotein whichfunction as an electron carrier for several membrane boundoxygenases. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGAP19_CYB5A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_110aa MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQMTDQSXTSLRKLLSLLLILVPVGGPTGX >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_18aa >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_100aa MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQKLLSLLLILVPVGGPTGXSLPSLQWPSP >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_110aa MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQMTDQSXTSLRKLLSLLLILVPVGGPTGX >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_18aa >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_100aa MATEAQSEGEVPARESGRSILVGKKFXGNKLEVTLLRTLRMSGTLQMPGKCPKHSSLGSSIQKLLSLLLILVPVGGPTGXSLPSLQWPSP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_332nt ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC ATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGA >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_56nt >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_302nt ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC ATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCT >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_332nt ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC ATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGA >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_56nt >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_302nt ATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAG CTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCC ATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_649nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTC TAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTG AACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCT TCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAA TTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAAT >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_672nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAACCTTAAAGGCGGTGTTTCAAGGA AACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTA TCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCT AACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAA AGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTA >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_477nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGAT CCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGA GCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCT >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000340533_chr18_71930712_-_649nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTC TAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTG AACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCT TCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAA TTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAAT >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000494131_chr18_71930712_-_672nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAACCTTAAAGGCGGTGTTTCAAGGA AACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTA TCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCT AACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAA AGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTA >In-frame_ARHGAP19_ENST00000358531_chr10_99052329_-_CYB5A_ENST00000397914_chr18_71930712_-_477nt GGGGCGGTGAAAGAAGTTTGCTGACGAAGATGGCGACTGAGGCACAGAGTGAAGGGGAGGTGCCAGCCCGCGAATCCGGCCGGAGCATCC TGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAAT GTCCAAAACATTCATCATTGGGGAGCTCCATCCAGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGAT CCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGA GCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCT |
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FusionGenePPI for ARHGAP19_CYB5A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARHGAP19 | ELAVL1, ATXN3, LRRC47, RASA3, LYN, DEFA5, FHIT, IKZF5, DCAF16, RNF41, TDRKH, LRP2, ERBB2IP, CBY1 | CYB5A | CYCS, UCHL5, CYP2E1, CYP2D6, CYP3A4, CYP2A6, CYP1A2, CYP4A11, UGT1A4, CYP2W1, FYTTD1, OR10H3, SOX2, SLC38A6, ISYNA1, ENDOD1, HSPA14, RABGAP1L, AGPAT4, TAB1, BCAP31, SNX2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP19_CYB5A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP19_CYB5A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CYB5A | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | CYB5A | C0028754 | Obesity | 1 | CTD_human |
Tgene | CYB5A | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |