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Fusion gene ID: 23842 |
FusionGeneSummary for NDUFA7_PRKCG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFA7_PRKCG | Fusion gene ID: 23842 | Hgene | Tgene | Gene symbol | NDUFA7 | PRKCG | Gene ID | 4701 | 5582 |
| Gene name | NADH:ubiquinone oxidoreductase subunit A7 | protein kinase C gamma | |
| Synonyms | B14.5a|CI-B14.5a | PKC-gamma|PKCC|PKCG|SCA14 | |
| Cytomap | 19p13.2 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5acomplex I B14.5a subunit | protein kinase C gamma type | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95182 | P05129 | |
| Ensembl transtripts involved in fusion gene | ENST00000598884, ENST00000301457, | ENST00000536044, ENST00000540413, ENST00000263431, ENST00000542049, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NDUFA7 [Title/Abstract] AND PRKCG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCG | GO:0016310 | phosphorylation | 15808853 |
| Tgene | PRKCG | GO:0031397 | negative regulation of protein ubiquitination | 15808853 |
| Tgene | PRKCG | GO:0032425 | positive regulation of mismatch repair | 15808853 |
| Tgene | PRKCG | GO:0042177 | negative regulation of protein catabolic process | 15808853 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-D6-6515-01A | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000598884 | ENST00000536044 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000598884 | ENST00000540413 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000598884 | ENST00000263431 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000598884 | ENST00000542049 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000301457 | ENST00000536044 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000301457 | ENST00000540413 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000301457 | ENST00000263431 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
| 5CDS-intron | ENST00000301457 | ENST00000542049 | NDUFA7 | chr19 | 8381380 | - | PRKCG | chr19 | 54406327 | + |
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FusionProtFeatures for NDUFA7_PRKCG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFA7 | PRKCG |
| Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. | Calcium-activated, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that plays diverseroles in neuronal cells and eye tissues, such as regulation of theneuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation ofreceptors and neuronal functions related to sensitivity toopiates, pain and alcohol, mediation of synaptic function and cellsurvival after ischemia, and inhibition of gap junction activityafter oxidative stress. Binds and phosphorylates GRIA4/GLUR4glutamate receptor and regulates its function by increasing plasmamembrane-associated GRIA4 expression. In primary cerebellarneurons treated with the agonist 3,5-dihyidroxyphenylglycine,functions downstream of the metabotropic glutamate receptorGRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays akey role in synaptic plasticity, synaptogenesis, excitotoxicity,memory acquisition and learning. May be involved in the regulationof hippocampal long-term potentiation (LTP), but may be notnecessary for the process of synaptic plasticity. May be involvedin desensitization of mu-type opioid receptor-mediated G-proteinactivation in the spinal cord, and may be critical for thedevelopment and/or maintenance of morphine-induced reinforcingeffects in the limbic forebrain. May modulate the functionality ofmu-type-opioid receptors by participating in a signaling pathwaywhich leads to the phosphorylation and degradation of opioidreceptors. May also contributes to chronic morphine-inducedchanges in nociceptive processing. Plays a role in neuropathicpain mechanisms and contributes to the maintenance of theallodynia pain produced by peripheral inflammation. Plays animportant role in initial sensitivity and tolerance to ethanol, bymediating the behavioral effects of ethanol as well as the effectsof this drug on the GABA(A) receptors. During and after cerebralischemia modulate neurotransmission and cell survival in synapticmembranes, and is involved in insulin-induced inhibition ofnecrosis, an important mechanism for minimizing ischemic injury.Required for the elimination of multiple climbing fibers duringinnervation of Purkinje cells in developing cerebellum. Isactivated in lens epithelial cells upon hydrogen peroxidetreatment, and phosphorylates connexin-43 (GJA1/CX43), resultingin disassembly of GJA1 gap junction plaques and inhibition of gapjunction activity which could provide a protective effect againstoxidative stress (By similarity). Phosphorylates p53/TP53 andpromotes p53/TP53-dependent apoptosis in response to DNA damage.Involved in the phase resetting of the cerebral cortex circadianclock during temporally restricted feeding. Stabilizes the coreclock component ARNTL/BMAL1 by interfering with itsubiquitination, thus suppressing its degradation, resulting inphase resetting of the cerebral cortex clock (By similarity).{ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319,ECO:0000269|PubMed:16377624}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFA7_PRKCG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDUFA7_PRKCG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDUFA7 | PRKAB1, RPL38, TIMM44, RRBP1, PIN1, SBDS, RAB8A, PDLIM5, RBM27, MRRF, TAGLN, PIN4, RANGAP1, UBL4A, PDLIM7, TPX2, UBE2L3, SNX3, ECI2, HRSP12, RBMS1, SUGP1, QKI, PQBP1, KIAA0101, RPS10P5, TBL2, RFX5, STX7, MPLKIP, SNRPC, SCO2, NABP2, MRPS28, ZC3H11A, CDV3, MRPL14, OLA1, SRRM2, TOMM40, RPS28, UBE2I, GATAD2B, UBE4B, VDAC3, SCP2, ACAA1, NUP214, MDFI, UPF2, NDUFS3, TMX2, DNAJC30, GJA1, ENPP6, NDUFA8, VAPB, NDUFA12, NDUFS4, NDUFS5, NDUFA9, NDUFS6, RAB5C, RAB7A, VAPA, GOLT1B, MMGT1, NDUFA4, C15orf48, COX6B1, NDUFB11, NDUFS7, NDUFA13, SSMEM1, FUT1 | PRKCG | YWHAG, GRIA4, RGS2, TIAM1, AFAP1, GABRA1, GABRA4, NFE2L2, PRKCG, DDX58, IBTK, PICK1, NOXA1, EXOC5, CCHCR1, TOP2A, APP, SDC2, ITGB2, HSP90AA1, GSK3A, CASR, ARHGEF25, RANBP10, GFAP, HSPA4, EPHB1, SCN3A, TRIM5, RANBP9, DAB2, CTNNB1, SMURF1, UBE2T, PRKCA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFA7_PRKCG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFA7_PRKCG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRKCG | C0020429 | Hyperalgesia | 2 | CTD_human |
| Tgene | PRKCG | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| Tgene | PRKCG | C0087012 | Ataxia, Spinocerebellar | 1 | CTD_human |
| Tgene | PRKCG | C1854369 | Spinocerebellar ataxia 14 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | PRKCG | C3714756 | Intellectual Disability | 1 | CTD_human |
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