FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23836

FusionGeneSummary for NDUFA1_SPRED2

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFA1_SPRED2
Fusion gene ID: 23836
HgeneTgene
Gene symbol

NDUFA1

SPRED2

Gene ID

4694

200734

Gene nameNADH:ubiquinone oxidoreductase subunit A1sprouty related EVH1 domain containing 2
SynonymsCI-MWFE|MWFE|ZNF183Spred-2
Cytomap

Xq24

2p14

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDaNADH-ubiquinone oxidoreductase MWFE subunitNADH:ubiquinone oxidoreductase (complex 1)complex I MWFE subunittype I dehydrogenasesprouty-related, EVH1 domain-containing protein 2sprouty protein with EVH-1 domain 2, related sequence
Modification date2018052220180519
UniProtAcc

O15239

Q7Z698

Ensembl transtripts involved in fusion geneENST00000371437, ENST00000356388, 
ENST00000443619, ENST00000474228, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDUFA1 [Title/Abstract] AND SPRED2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA311962NDUFA1chrX

119010556

-SPRED2chr2

65540124

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000371437ENST00000356388NDUFA1chrX

119010556

-SPRED2chr2

65540124

+
3UTR-intronENST00000371437ENST00000443619NDUFA1chrX

119010556

-SPRED2chr2

65540124

+
3UTR-intronENST00000371437ENST00000474228NDUFA1chrX

119010556

-SPRED2chr2

65540124

+

Top

FusionProtFeatures for NDUFA1_SPRED2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFA1

O15239

SPRED2

Q7Z698

Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. Negatively regulates Ras signaling pathways anddownstream activation of MAP kinases.{ECO:0000269|PubMed:15683364}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NDUFA1_SPRED2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NDUFA1_SPRED2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NDUFA1_SPRED2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NDUFA1_SPRED2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDUFA1C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY1CTD_human;UNIPROT
TgeneSPRED2C0003873Rheumatoid Arthritis2CTD_human