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Fusion gene ID: 23821 |
FusionGeneSummary for NDST4_TRPC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDST4_TRPC3 | Fusion gene ID: 23821 | Hgene | Tgene | Gene symbol | NDST4 | TRPC3 | Gene ID | 64579 | 7222 |
| Gene name | N-deacetylase and N-sulfotransferase 4 | transient receptor potential cation channel subfamily C member 3 | |
| Synonyms | N-HSST|N-HSST 4|NDST-4|NHSST4 | SCA41|TRP3 | |
| Cytomap | 4q26 | 4q27 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4N-deacetylase/N-sulfotransferase 4N-heparan sulfate sulfotransferase 4glucosaminyl N-deacetylase/N-sulfotransferase 4 | short transient receptor potential channel 3hTrp-3transient receptor potential cation channel subfamily C member 3 variant ctransient receptor protein 3 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q9H3R1 | Q13507 | |
| Ensembl transtripts involved in fusion gene | ENST00000264363, | ENST00000264811, ENST00000379645, ENST00000513531, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NDST4 [Title/Abstract] AND TRPC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRPC3 | GO:0010524 | positive regulation of calcium ion transport into cytosol | 21062895 |
| Tgene | TRPC3 | GO:0033198 | response to ATP | 21062895 |
| Tgene | TRPC3 | GO:0051592 | response to calcium ion | 21062895 |
| Tgene | TRPC3 | GO:0070588 | calcium ion transmembrane transport | 21062895 |
| Tgene | TRPC3 | GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress | 19287093 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | U47050 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000264363 | ENST00000264811 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
| 5UTR-5UTR | ENST00000264363 | ENST00000379645 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
| 5UTR-intron | ENST00000264363 | ENST00000513531 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
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FusionProtFeatures for NDST4_TRPC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDST4 | TRPC3 |
| Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has low deacetylase activity but highsulfotransferase activity (By similarity). {ECO:0000250}. | Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Activated bydiacylglycerol (DAG) in a membrane-delimited fashion,independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also beactivated by internal calcium store depletion.{ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775,ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDST4_TRPC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDST4_TRPC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDST4 | TRPC3 | ITPR1, TRPC1, TRPC4, TRPC5, TRPC3, TRPC6, TRPC7, ITPR3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDST4_TRPC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDST4_TRPC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TRPC3 | C0005586 | Bipolar Disorder | 1 | CTD_human |
| Tgene | TRPC3 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | TRPC3 | C4225158 | SPINOCEREBELLAR ATAXIA 41 | 1 | ORPHANET;UNIPROT |
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