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Fusion gene ID: 23821 |
FusionGeneSummary for NDST4_TRPC3 |
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Fusion gene information | Fusion gene name: NDST4_TRPC3 | Fusion gene ID: 23821 | Hgene | Tgene | Gene symbol | NDST4 | TRPC3 | Gene ID | 64579 | 7222 |
Gene name | N-deacetylase and N-sulfotransferase 4 | transient receptor potential cation channel subfamily C member 3 | |
Synonyms | N-HSST|N-HSST 4|NDST-4|NHSST4 | SCA41|TRP3 | |
Cytomap | 4q26 | 4q27 | |
Type of gene | protein-coding | protein-coding | |
Description | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4N-deacetylase/N-sulfotransferase 4N-heparan sulfate sulfotransferase 4glucosaminyl N-deacetylase/N-sulfotransferase 4 | short transient receptor potential channel 3hTrp-3transient receptor potential cation channel subfamily C member 3 variant ctransient receptor protein 3 | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | Q9H3R1 | Q13507 | |
Ensembl transtripts involved in fusion gene | ENST00000264363, | ENST00000264811, ENST00000379645, ENST00000513531, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NDST4 [Title/Abstract] AND TRPC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRPC3 | GO:0010524 | positive regulation of calcium ion transport into cytosol | 21062895 |
Tgene | TRPC3 | GO:0033198 | response to ATP | 21062895 |
Tgene | TRPC3 | GO:0051592 | response to calcium ion | 21062895 |
Tgene | TRPC3 | GO:0070588 | calcium ion transmembrane transport | 21062895 |
Tgene | TRPC3 | GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress | 19287093 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | U47050 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000264363 | ENST00000264811 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
5UTR-5UTR | ENST00000264363 | ENST00000379645 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
5UTR-intron | ENST00000264363 | ENST00000513531 | NDST4 | chr4 | 116034598 | - | TRPC3 | chr4 | 122854200 | - |
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FusionProtFeatures for NDST4_TRPC3 |
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Hgene | Tgene |
NDST4 | TRPC3 |
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has low deacetylase activity but highsulfotransferase activity (By similarity). {ECO:0000250}. | Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Activated bydiacylglycerol (DAG) in a membrane-delimited fashion,independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also beactivated by internal calcium store depletion.{ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775,ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDST4_TRPC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDST4_TRPC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDST4 | TRPC3 | ITPR1, TRPC1, TRPC4, TRPC5, TRPC3, TRPC6, TRPC7, ITPR3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDST4_TRPC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDST4_TRPC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRPC3 | C0005586 | Bipolar Disorder | 1 | CTD_human |
Tgene | TRPC3 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | TRPC3 | C4225158 | SPINOCEREBELLAR ATAXIA 41 | 1 | ORPHANET;UNIPROT |