FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23821

FusionGeneSummary for NDST4_TRPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: NDST4_TRPC3
Fusion gene ID: 23821
HgeneTgene
Gene symbol

NDST4

TRPC3

Gene ID

64579

7222

Gene nameN-deacetylase and N-sulfotransferase 4transient receptor potential cation channel subfamily C member 3
SynonymsN-HSST|N-HSST 4|NDST-4|NHSST4SCA41|TRP3
Cytomap

4q26

4q27

Type of geneprotein-codingprotein-coding
Descriptionbifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4N-deacetylase/N-sulfotransferase 4N-heparan sulfate sulfotransferase 4glucosaminyl N-deacetylase/N-sulfotransferase 4short transient receptor potential channel 3hTrp-3transient receptor potential cation channel subfamily C member 3 variant ctransient receptor protein 3
Modification date2018052720180527
UniProtAcc

Q9H3R1

Q13507

Ensembl transtripts involved in fusion geneENST00000264363, ENST00000264811, 
ENST00000379645, ENST00000513531, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: NDST4 [Title/Abstract] AND TRPC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRPC3

GO:0010524

positive regulation of calcium ion transport into cytosol

21062895

TgeneTRPC3

GO:0033198

response to ATP

21062895

TgeneTRPC3

GO:0051592

response to calcium ion

21062895

TgeneTRPC3

GO:0070588

calcium ion transmembrane transport

21062895

TgeneTRPC3

GO:1903244

positive regulation of cardiac muscle hypertrophy in response to stress

19287093


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U47050NDST4chr4

116034598

-TRPC3chr4

122854200

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000264363ENST00000264811NDST4chr4

116034598

-TRPC3chr4

122854200

-
5UTR-5UTRENST00000264363ENST00000379645NDST4chr4

116034598

-TRPC3chr4

122854200

-
5UTR-intronENST00000264363ENST00000513531NDST4chr4

116034598

-TRPC3chr4

122854200

-

Top

FusionProtFeatures for NDST4_TRPC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDST4

Q9H3R1

TRPC3

Q13507

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has low deacetylase activity but highsulfotransferase activity (By similarity). {ECO:0000250}. Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Activated bydiacylglycerol (DAG) in a membrane-delimited fashion,independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also beactivated by internal calcium store depletion.{ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775,ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NDST4_TRPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NDST4_TRPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NDST4TRPC3ITPR1, TRPC1, TRPC4, TRPC5, TRPC3, TRPC6, TRPC7, ITPR3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NDST4_TRPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NDST4_TRPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRPC3C0005586Bipolar Disorder1CTD_human
TgeneTRPC3C0020538Hypertensive disease1CTD_human
TgeneTRPC3C4225158SPINOCEREBELLAR ATAXIA 411ORPHANET;UNIPROT