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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23816

FusionGeneSummary for NDRG4_NDRG4

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG4_NDRG4
Fusion gene ID: 23816
HgeneTgene
Gene symbol

NDRG4

NDRG4

Gene ID

65009

65009

Gene nameNDRG family member 4NDRG family member 4
SynonymsBDM1|SMAP-8|SMAP8BDM1|SMAP-8|SMAP8
Cytomap

16q21

16q21

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG4N-myc downstream-regulated gene 4 proteinbrain development-related molecule 1smooth muscle-associated protein 8vascular smooth muscle cell-associated protein 8protein NDRG4N-myc downstream-regulated gene 4 proteinbrain development-related molecule 1smooth muscle-associated protein 8vascular smooth muscle cell-associated protein 8
Modification date2018052320180523
UniProtAcc

Q9ULP0

Q9ULP0

Ensembl transtripts involved in fusion geneENST00000258187, ENST00000394282, 
ENST00000394279, ENST00000566192, 
ENST00000568640, ENST00000563022, 
ENST00000569923, ENST00000356752, 
ENST00000563799, ENST00000562999, 
ENST00000570248, 		ENST00000258187, 
ENST00000394282, ENST00000394279, 
ENST00000566192, ENST00000568640, 
ENST00000563022, ENST00000569923, 
ENST00000356752, ENST00000563799, 
ENST00000562999, ENST00000570248, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDRG4 [Title/Abstract] AND NDRG4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDRG4

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

12755708

HgeneNDRG4

GO:0014912

negative regulation of smooth muscle cell migration

12755708

HgeneNDRG4

GO:0048662

negative regulation of smooth muscle cell proliferation

12755708

HgeneNDRG4

GO:0070374

positive regulation of ERK1 and ERK2 cascade

12755708

TgeneNDRG4

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

12755708

TgeneNDRG4

GO:0014912

negative regulation of smooth muscle cell migration

12755708

TgeneNDRG4

GO:0048662

negative regulation of smooth muscle cell proliferation

12755708

TgeneNDRG4

GO:0070374

positive regulation of ERK1 and ERK2 cascade

12755708


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI267605NDRG4chr16

58546828

-NDRG4chr16

58547109

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000258187ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000258187ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000258187ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000258187ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000258187ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000258187ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394282ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394282ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394282ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394282ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394282ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394279ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394279ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394279ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000394279ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000394279ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000566192ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000566192ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000566192ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000566192ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000566192ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000568640ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000568640ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000568640ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000568640ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000568640ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000563022ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000563022ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000563022ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000563022ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000563022ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000569923ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000569923ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000569923ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000569923ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000569923ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000356752ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000356752ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000356752ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-intronENST00000356752ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
intron-3UTRENST00000356752ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000563799ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000563799ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000563799ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000563799ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000563799ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000562999ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000562999ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000562999ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000562999ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000562999ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000258187NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000394282NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000394279NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000566192NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000570248ENST00000568640NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000570248ENST00000563022NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000570248ENST00000569923NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-intronENST00000570248ENST00000356752NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000563799NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000562999NDRG4chr16

58546828

-NDRG4chr16

58547109

+
3UTR-3UTRENST00000570248ENST00000570248NDRG4chr16

58546828

-NDRG4chr16

58547109

+

Top

FusionProtFeatures for NDRG4_NDRG4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG4

Q9ULP0

NDRG4

Q9ULP0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NDRG4_NDRG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDRG4_NDRG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NDRG4_NDRG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NDRG4_NDRG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource