FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23815

FusionGeneSummary for NDRG3_ZXDC

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG3_ZXDC
Fusion gene ID: 23815
HgeneTgene
Gene symbol

NDRG3

ZXDC

Gene ID

57446

79364

Gene nameNDRG family member 3ZXD family zinc finger C
Synonyms-ZXDL
Cytomap

20q11.23

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG3N-myc downstream-regulated gene 3 proteinzinc finger protein ZXDCSERH2790ZXD-like zinc finger protein
Modification date2018052320180519
UniProtAcc

Q9UGV2

Q2QGD7

Ensembl transtripts involved in fusion geneENST00000373803, ENST00000359675, 
ENST00000349004, ENST00000373773, 
ENST00000540765, 
ENST00000389709, 
ENST00000336332, 
Fusion gene scores* DoF score6 X 7 X 3=1263 X 5 X 1=15
# samples 75
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDRG3 [Title/Abstract] AND ZXDC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZXDC

GO:0045893

positive regulation of transcription, DNA-templated

17696781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA845639NDRG3chr20

35280577

+ZXDCchr3

126171895

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000373803ENST00000389709NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000373803ENST00000336332NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000359675ENST00000389709NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000359675ENST00000336332NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000349004ENST00000389709NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000349004ENST00000336332NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000373773ENST00000389709NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000373773ENST00000336332NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000540765ENST00000389709NDRG3chr20

35280577

+ZXDCchr3

126171895

+
intron-intronENST00000540765ENST00000336332NDRG3chr20

35280577

+ZXDCchr3

126171895

+

Top

FusionProtFeatures for NDRG3_ZXDC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG3

Q9UGV2

ZXDC

Q2QGD7

Cooperates with CIITA to promote transcription of MHCclass I and MHC class II genes. {ECO:0000269|PubMed:16600381,ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NDRG3_ZXDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NDRG3_ZXDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NDRG3_ZXDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NDRG3_ZXDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource