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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 238

FusionGeneSummary for ABI1_YME1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI1_YME1L1
Fusion gene ID: 238
HgeneTgene
Gene symbol

ABI1

YME1L1

Gene ID

10006

10730

Gene nameabl interactor 1YME1 like 1 ATPase
SynonymsABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1FTSH|MEG4|OPA11|PAMP|YME1L
Cytomap

10p12.1

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionabl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1ATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloprotease
Modification date2018052220180523
UniProtAcc

Q8IZP0

Q96TA2

Ensembl transtripts involved in fusion geneENST00000376170, ENST00000359188, 
ENST00000376142, ENST00000376139, 
ENST00000376160, ENST00000376166, 
ENST00000376138, ENST00000355394, 
ENST00000490841, ENST00000376137, 
ENST00000346832, ENST00000536334, 
ENST00000376134, ENST00000376140, 
ENST00000473481, 
ENST00000326799, 
ENST00000376016, ENST00000375972, 
ENST00000463270, ENST00000477432, 
Fusion gene scores* DoF score7 X 5 X 5=1756 X 6 X 3=108
# samples 87
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABI1 [Title/Abstract] AND YME1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133

TgeneYME1L1

GO:0034214

protein hexamerization

27786171


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA016422ABI1chr10

27112067

-YME1L1chr10

27409478

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000376170ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376170ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376170ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376170ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376170ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000359188ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000359188ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376142ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376142ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376139ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376139ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376160ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376160ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376166ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376166ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376138ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376138ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000355394ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000355394ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000490841ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000490841ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376137ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376137ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000346832ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000346832ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000536334ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000536334ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376134ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376134ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376140ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376140ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-intronENST00000473481ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-intronENST00000473481ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-

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FusionProtFeatures for ABI1_YME1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABI1

Q8IZP0

YME1L1

Q96TA2

ATP-dependent metalloprotease that catalyzes thedegradation of folded and unfolded proteins with a suitable degronsequence in the mitochondrial intermembrane region(PubMed:26923599, PubMed:27786171). Plays an important role inregulating mitochondrial morphology and function by cleaving OPA1at position S2, giving rise to a form of OPA1 that promotesmaintenance of normal mitochondrial structure and mitochondrialprotein metabolism (PubMed:18076378, PubMed:26923599,PubMed:27495975). Ensures cell proliferation, maintains normalcristae morphology and complex I respiration activity, promotesantiapoptotic activity and protects mitochondria from theaccumulation of oxidatively damaged membrane proteins(PubMed:22262461). Required for normal, constitutive degradationof PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 inresponse to membrane depolarization (PubMed:26923599). Required tocontrol the accumulation of nonassembled respiratory chainsubunits (NDUFB6, OX4 and ND1) (PubMed:22262461).{ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461,ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975,ECO:0000269|PubMed:27786171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABI1_YME1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABI1_YME1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABI1ENAH, NCKAP1, EPS8L1, EPS8L2, EPS8L3, EPS8, ABL1, SOS1, NCK1, RYK, CACNA1A, CBL, NCK2, CDC123, CTTN, PIK3R1, PRKAA1, SRRM1, TCERG1, PRPF40A, APBB1, GAS7, WASF2, ZNF511, ODF3L2, UBXN11, VASP, DTNBP1, LHX4, PCMT1, BAIAP2, CYFIP1, CYFIP2, NCKAP1L, SF3A3, SSB, WASF1, WASL, MKI67, NHS, PPP2R1A, HOMER3, ABI2, RBM14, BRK1, NHSL1, KIAA1522, RAPH1, THOC6, TCF4, ZNF746, CDH1, IKBIP, AMZ1, WASF3, TIMM50, NHSL2, CGB2, COG6, CCDC22, C10orf88, CDH23, NXNYME1L1PSEN1, ICT1, FKBP8, DAP3, VDAC3, SSBP1, COX2, NDUFB6, ND5, ND2, ND6, MYOG, BCL11A, DYRK4, HIPK4, PHKG2, UNK, ATP5A1, ATP5F1, CAD, NTRK1, PTEN, NDUFA11, NDUFA13, TIMMDC1, TBC1D9, AP4E1, TMEM63B, GEMIN7, ENTHD2, CHCHD10, APOOL, OPA3, OCIAD1, PDP2, TTC25, INTU


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABI1_YME1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABI1_YME1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource