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Fusion gene ID: 23765 |
FusionGeneSummary for NDE1_LRRC26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDE1_LRRC26 | Fusion gene ID: 23765 | Hgene | Tgene | Gene symbol | NDE1 | LRRC26 | Gene ID | 54820 | 389816 |
| Gene name | nudE neurodevelopment protein 1 | leucine rich repeat containing 26 | |
| Synonyms | HOM-TES-87|LIS4|MHAC|NDE|NUDE|NUDE1 | CAPC|bA350O14.10 | |
| Cytomap | 16p13.11 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear distribution protein nudE homolog 1LIS1-interacting protein NUDE1, rat homolognudE nuclear distribution E homolog 1nudE nuclear distribution gene E homolog 1 | leucine-rich repeat-containing protein 26BK channel auxiliary gamma subunit LRRC26BK channel auxilliary gamma subunit LRRC26cytokeratin associated proteincytokeratin-associated protein in cancer | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NXR1 | Q2I0M4 | |
| Ensembl transtripts involved in fusion gene | ENST00000396353, ENST00000396355, ENST00000396354, ENST00000342673, ENST00000571896, | ENST00000371542, | |
| Fusion gene scores | * DoF score | 7 X 8 X 1=56 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/56*10)=0.836501267717121 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NDE1 [Title/Abstract] AND LRRC26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LRRC26 | GO:0071805 | potassium ion transmembrane transport | 22547800 |
| Tgene | LRRC26 | GO:1903818 | positive regulation of voltage-gated potassium channel activity | 22547800 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE855941 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000396353 | ENST00000371542 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
| intron-3CDS | ENST00000396355 | ENST00000371542 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
| intron-3CDS | ENST00000396354 | ENST00000371542 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
| intron-3CDS | ENST00000342673 | ENST00000371542 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
| intron-3CDS | ENST00000571896 | ENST00000371542 | NDE1 | chr16 | 15802691 | + | LRRC26 | chr9 | 140063360 | + |
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FusionProtFeatures for NDE1_LRRC26 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDE1 | LRRC26 |
| Required for centrosome duplication and formation andfunction of the mitotic spindle. Essential for the development ofthe cerebral cortex. May regulate the production of neurons bycontrolling the orientation of the mitotic spindle during divisionof cortical neuronal progenitors of the proliferative ventricularzone of the brain. Orientation of the division plane perpendicularto the layers of the cortex gives rise to two proliferativeneuronal progenitors whereas parallel orientation of the divisionplane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate withinthe progenitor population may result in an overall reduction inthe final number of neurons and an increase in the number ofneurons in the deeper layers of the cortex.{ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752}. | Auxiliary protein of the large-conductance, voltage andcalcium-activated potassium channel (BK alpha). Required for theconversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These arecharacterized by negative membrane voltages and constant lowlevels of calcium. {ECO:0000269|PubMed:20613726,ECO:0000269|PubMed:22547800}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDE1_LRRC26 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDE1_LRRC26 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDE1_LRRC26 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDE1_LRRC26 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NDE1 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Hgene | NDE1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | NDE1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
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