FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23748

FusionGeneSummary for NCS1_GPR107

check button Fusion gene summary
Fusion gene informationFusion gene name: NCS1_GPR107
Fusion gene ID: 23748
HgeneTgene
Gene symbol

NCS1

GPR107

Gene ID

23413

57720

Gene nameneuronal calcium sensor 1G protein-coupled receptor 107
SynonymsFLUP|FREQGCDRP|LUSTR1|bA138E2.2
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionneuronal calcium sensor 1frequenin homologfrequenin-like proteinfrequenin-like ubiquitous proteinprotein GPR107lung seven transmembrane receptor 1
Modification date2018052220180519
UniProtAcc

P62166

Q5VW38

Ensembl transtripts involved in fusion geneENST00000372398, ENST00000493042, 
ENST00000458469, 
ENST00000347136, 
ENST00000372406, ENST00000372410, 
ENST00000415344, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 2=72
# samples 46
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCS1 [Title/Abstract] AND GPR107 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5J9-01ANCS1chr9

132935006

+GPR107chr9

132889762

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000372398ENST00000347136NCS1chr9

132935006

+GPR107chr9

132889762

+
Frame-shiftENST00000372398ENST00000372406NCS1chr9

132935006

+GPR107chr9

132889762

+
Frame-shiftENST00000372398ENST00000372410NCS1chr9

132935006

+GPR107chr9

132889762

+
5CDS-intronENST00000372398ENST00000415344NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000493042ENST00000347136NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000493042ENST00000372406NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000493042ENST00000372410NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-intronENST00000493042ENST00000415344NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000458469ENST00000347136NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000458469ENST00000372406NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-3CDSENST00000458469ENST00000372410NCS1chr9

132935006

+GPR107chr9

132889762

+
intron-intronENST00000458469ENST00000415344NCS1chr9

132935006

+GPR107chr9

132889762

+

Top

FusionProtFeatures for NCS1_GPR107


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCS1

P62166

GPR107

Q5VW38

Neuronal calcium sensor, regulator of G protein-coupledreceptor phosphorylation in a calcium dependent manner. Directlyregulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute forcalmodulin (By similarity). Stimulates PI4KB kinase activity (Bysimilarity). Involved in long-term synaptic plasticity through itsinteraction with PICK1 (By similarity). May also play a role inneuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). {ECO:0000250}. Involved in Golgi-to-ER retrograde transport. Functionsas a host factor required for infection by Pseudomonas aeruginosaexotoxin A and Campylobacter jejuni CDT toxins.{ECO:0000269|PubMed:25031321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NCS1_GPR107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NCS1_GPR107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCS1IL1RAPL1, DTX2, PI4KB, DRD2, DRD3, KCND2, ELAVL1, KDM3B, KIF21A, NAF1, SNRPB, SRP68, NBL1, SLC25A41, NUFIP1, FSD1, TMEM185A, HSD17B3, CEP89, XPO1, BSPRY, ABHD6, NMT2, USP24, TK1, NMT1, ICAM1, CNOT3, FCGR3AGPR107TMEM17, TMEM216, TRAF2, BIRC2, LNPEP, REEP5, NDUFA12, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NCS1_GPR107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNCS1P62166DB11093Calcium CitrateNeuronal calcium sensor 1small moleculeapproved
HgeneNCS1P62166DB11348Calcium PhosphateNeuronal calcium sensor 1small moleculeapproved

Top

RelatedDiseases for NCS1_GPR107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCS1C0005586Bipolar Disorder2PSYGENET
HgeneNCS1C0036341Schizophrenia2PSYGENET
HgeneNCS1C0600427Cocaine Dependence1PSYGENET