|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23697 |
FusionGeneSummary for NCOA6_GGT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCOA6_GGT7 | Fusion gene ID: 23697 | Hgene | Tgene | Gene symbol | NCOA6 | GGT7 | Gene ID | 23054 | 2686 |
| Gene name | nuclear receptor coactivator 6 | gamma-glutamyltransferase 7 | |
| Synonyms | AIB3|ASC2|NRC|PRIP|RAP250|TRBP | D20S101|GGT4|GGTL3|GGTL5 | |
| Cytomap | 20q11.22 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor coactivator 6NRC RAP250PPAR-interacting proteinactivating signal cointegrator-2amplified in breast cancer protein 3amplified in breast cancer-3 proteincancer-amplified transcriptional coactivator ASC-2nuclear receptor coactivator R | glutathione hydrolase 7GGT 7gamma-glutamyltransferase 4gamma-glutamyltransferase-like 3gamma-glutamyltransferase-like 5gamma-glutamyltranspeptidase 7gamma-glutamyltranspeptidase-like 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14686 | Q9UJ14 | |
| Ensembl transtripts involved in fusion gene | ENST00000593786, ENST00000374796, ENST00000359003, | ENST00000336431, ENST00000469018, | |
| Fusion gene scores | * DoF score | 12 X 7 X 10=840 | 2 X 2 X 2=8 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/840*10)=-2.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NCOA6 [Title/Abstract] AND GGT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCOA6 | GO:0006352 | DNA-templated transcription, initiation | 10567404 |
| Hgene | NCOA6 | GO:0006974 | cellular response to DNA damage stimulus | 17500065 |
| Hgene | NCOA6 | GO:0030099 | myeloid cell differentiation | 11302752 |
| Hgene | NCOA6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11443112 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-AA6D-01A | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000593786 | ENST00000336431 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| intron-intron | ENST00000593786 | ENST00000469018 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| intron-3CDS | ENST00000374796 | ENST00000336431 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| intron-intron | ENST00000374796 | ENST00000469018 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| 5UTR-3CDS | ENST00000359003 | ENST00000336431 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
| 5UTR-intron | ENST00000359003 | ENST00000469018 | NCOA6 | chr20 | 33413275 | - | GGT7 | chr20 | 33440341 | - |
Top |
FusionProtFeatures for NCOA6_GGT7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCOA6 | GGT7 |
| Nuclear receptor coactivator that directly binds nuclearreceptors and stimulates the transcriptional activities in ahormone-dependent fashion. Coactivates expression in anagonist- and AF2-dependent manner. Involved in the coactivation ofdifferent nuclear receptors, such as for steroids (GR and ERs),retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR)and prostanoids (PPARs). Probably functions as a generalcoactivator, rather than just a nuclear receptor coactivator. Mayalso be involved in the coactivation of the NF-kappa-B pathway.May coactivate expression via a remodeling of chromatin and itsinteraction with histone acetyltransferase proteins. | Cleaves glutathione conjugates. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NCOA6_GGT7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NCOA6_GGT7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCOA6 | ASCL2, KMT2C, RBBP5, AR, LAMTOR5, FOS, JUN, NFKB1, RELA, SRF, ESR2, RARA, THRB, CREBBP, ESR1, NR3C1, THRA, NR1H2, RB1, HIST2H3C, RXRA, E2F1, CEBPA, ASCC1, ATF2, SRC, TBP, GTF2A1, CD40, PRKDC, XRCC5, XRCC6, MED23, EP300, TGS1, ZNF335, NUMA1, PARP1, TXNRD2, NCOR2, KDM6A, KMT2B, UTY, PAXIP1, ASH2L, DPY30, WDR5, HNF4A, PPARGC1A, NCOA6, PAGR1, NR1H4, PPARG, RORC, RANBP9, NR1H3, FHOD1, RORB, TRA, TRB, VDR, NR1I2, GRIP1, NCOA1, MED1, RANGAP1, MED15, UBC, SMAD3, SMAD2, FUS, HSF1, HCFC1, NCOA2, TUBA1A, EWSR1, MAFA, MAFB, FOXA1 | GGT7 | GGT7, DCP2, FAM96B, GPR25, MALL, LHFPL5, TMEM242, NAALAD2, TUSC3, PIGB, ST6GALNAC3, ALG12, SEC11C, DDX11, MANEA, POMT1, FAM69A, ZDHHC9, ABHD14A, RNF130, ALG9, MPZL1, ENTPD6, MANEAL, LSR, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NCOA6_GGT7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NCOA6_GGT7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NCOA6 | C0014175 | Endometriosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|