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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23691

FusionGeneSummary for NCOA4_SRSF7

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA4_SRSF7
Fusion gene ID: 23691
HgeneTgene
Gene symbol

NCOA4

SRSF7

Gene ID

8031

6432

Gene namenuclear receptor coactivator 4serine and arginine rich splicing factor 7
SynonymsARA70|ELE1|PTC3|RFG9G8|AAG3|SFRS7
Cytomap

10q11.22

2p22.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 470 kDa AR-activator70 kDa androgen receptor coactivatorNCoA-4RET-activating gene ELE1androgen receptor-associated protein of 70 kDaret fusedserine/arginine-rich splicing factor 7SR splicing factor 7aging-associated protein 3splicing factor 9G8splicing factor, arginine/serine-rich 7, 35kDa
Modification date2018051920180523
UniProtAcc

Q13772

Q16629

Ensembl transtripts involved in fusion geneENST00000438493, ENST00000452682, 
ENST00000498586, ENST00000430396, 
ENST00000374087, ENST00000414907, 
ENST00000344348, ENST00000374082, 
ENST00000443446, 
ENST00000313117, 
ENST00000446327, ENST00000409276, 
Fusion gene scores* DoF score8 X 4 X 7=2243 X 2 X 3=18
# samples 123
** MAII scorelog2(12/224*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA4 [Title/Abstract] AND SRSF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA4

GO:0006622

protein targeting to lysosome

25327288

TgeneSRSF7

GO:0008380

RNA splicing

8013463

TgeneSRSF7

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-Y6-A9XI-01ANCOA4chr10

51565296

-SRSF7chr2

38977336

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000438493ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000438493ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000438493ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000452682ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000452682ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000452682ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
3UTR-3CDSENST00000498586ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
3UTR-3CDSENST00000498586ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
3UTR-3CDSENST00000498586ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000430396ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000430396ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000430396ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000374087ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000374087ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000374087ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000414907ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000414907ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
5UTR-3CDSENST00000414907ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000344348ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000344348ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000344348ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000374082ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000374082ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000374082ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000443446ENST00000313117NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000443446ENST00000446327NCOA4chr10

51565296

-SRSF7chr2

38977336

-
intron-3CDSENST00000443446ENST00000409276NCOA4chr10

51565296

-SRSF7chr2

38977336

-

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FusionProtFeatures for NCOA4_SRSF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA4

Q13772

SRSF7

Q16629

Enhances the androgen receptor transcriptional activityin prostate cancer cells. Ligand-independent coactivator of theperoxisome proliferator-activated receptor (PPAR) gamma.{ECO:0000269|PubMed:10347167}. Required for pre-mRNA splicing. Can also modulatealternative splicing in vitro. Represses the splicing of MAPT/Tauexon 10. May function as export adapter involved in mRNA nuclearexport such as of histone H2A. Binds mRNA which is thought to betransferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding issemi-sequence specific. {ECO:0000269|PubMed:11336712,ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664,ECO:0000269|PubMed:18364396}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA4_SRSF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOA4_SRSF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOA4AR, PPARG, ESR1, GTF2B, KAT2B, NR3C1, VDR, AKT1, ATXN2, RXRA, HERC2, XPO1, GRIA2, KDR, KIFC3, PSMC1, XRCC3, HUWE1, PSMD14, TFG, KIF21A, USP43, FTH1, FTL, GMCL1, NEURL4SRSF7DUSP11, RNPS1, CDK19, SRRM1, RBM39, RBBP6, SREK1, HDGF, SF3A2, SH3KBP1, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, ALYREF, NXF1, HNRNPA1, HNRNPU, SF3A1, NHP2L1, PRPF6, SNRPA1, DHX9, SRSF11, SF3B3, U2AF1, SF3B6, U2AF2, SRSF5, HNRNPF, TRA2B, SFPQ, LUC7L3, IK, PRPF3, SART1, BUD31, DHX15, USP39, DDX21, SAP18, ILF2, PPP1CA, MSH2, GTF3C1, TRIM55, NFIA, SEPT7, SEPT2, SAFB, STT3B, TM9SF2, S100A9, VASN, SURF4, TFPI, ZRANB2, SON, HP1BP3, ESR1, BARD1, PAXIP1, EIF4A3, MAGOH, HNF1A, CDK6, PAN2, YWHAE, CLK3, SRPK2, SRPK1, TARDBP, NEDD4, ZBTB1, STAU1, CEP250, RELA, SDCBP, LUC7L2, ENO1, MOV10, CUL7, OBSL1, EZH2, SUZ12, EED, LUZP4, TRA2A, NTRK1, EIF3D, SRSF1, SRSF6, EIF3I, SRSF3, SRSF9, EWSR1, CLK1, XPO1, HIST1H3E, HSF2, MZT1, GAN, CDC5L, SNW1, WDR60


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOA4_SRSF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOA4_SRSF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA4C0040136Thyroid Neoplasm1CTD_human