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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23687

FusionGeneSummary for NCOA4_MSMB

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA4_MSMB
Fusion gene ID: 23687
HgeneTgene
Gene symbol

NCOA4

MSMB

Gene ID

8031

4477

Gene namenuclear receptor coactivator 4microseminoprotein beta
SynonymsARA70|ELE1|PTC3|RFGHPC13|IGBF|MSP|MSPB|PN44|PRPS|PSP|PSP-94|PSP57|PSP94
Cytomap

10q11.22

10q11.22

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 470 kDa AR-activator70 kDa androgen receptor coactivatorNCoA-4RET-activating gene ELE1androgen receptor-associated protein of 70 kDaret fusedbeta-microseminoproteinimmunoglobulin binding factorprostate secreted seminal plasma proteinprostate secretory protein of 94 amino acidsseminal plasma beta-inhibin
Modification date2018051920180519
UniProtAcc

Q13772

P08118

Ensembl transtripts involved in fusion geneENST00000438493, ENST00000452682, 
ENST00000498586, ENST00000430396, 
ENST00000374087, ENST00000414907, 
ENST00000344348, ENST00000374082, 
ENST00000443446, 		ENST00000358559, 
ENST00000474170, ENST00000298239, 
Fusion gene scores* DoF score8 X 4 X 7=2243 X 1 X 5=15
# samples 125
** MAII scorelog2(12/224*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/15*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA4 [Title/Abstract] AND MSMB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA4

GO:0006622

protein targeting to lysosome

25327288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A6B2-01ANCOA4chr10

51565296

+MSMBchr10

51555731

+
TCGARVLUSCTCGA-33-AASL-01ANCOA4chr10

51581378

+MSMBchr10

51555731

+
TCGARVTGCTTCGA-2G-AAFV-01ANCOA4chr10

51585599

+MSMBchr10

51555731

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000438493ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000438493ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000438493ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3CDSENST00000452682ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000452682ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000452682ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
3UTR-3CDSENST00000498586ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
3UTR-3UTRENST00000498586ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
3UTR-3UTRENST00000498586ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3CDSENST00000430396ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000430396ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000430396ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3CDSENST00000374087ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000374087ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000374087ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3CDSENST00000414907ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000414907ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
5UTR-3UTRENST00000414907ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3CDSENST00000344348ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000344348ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000344348ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3CDSENST00000374082ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000374082ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000374082ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3CDSENST00000443446ENST00000358559NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000443446ENST00000474170NCOA4chr10

51565296

+MSMBchr10

51555731

+
intron-3UTRENST00000443446ENST00000298239NCOA4chr10

51565296

+MSMBchr10

51555731

+
In-frameENST00000438493ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000438493ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000438493ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000452682ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000452682ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000452682ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
3UTR-3CDSENST00000498586ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
3UTR-3UTRENST00000498586ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
3UTR-3UTRENST00000498586ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000430396ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000430396ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000430396ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000374087ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374087ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374087ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
5UTR-3CDSENST00000414907ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5UTR-3UTRENST00000414907ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5UTR-3UTRENST00000414907ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000344348ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000344348ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000344348ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000374082ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374082ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374082ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000443446ENST00000358559NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000443446ENST00000474170NCOA4chr10

51581378

+MSMBchr10

51555731

+
5CDS-3UTRENST00000443446ENST00000298239NCOA4chr10

51581378

+MSMBchr10

51555731

+
In-frameENST00000438493ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000438493ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000438493ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000452682ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000452682ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000452682ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3CDSENST00000498586ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3UTRENST00000498586ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3UTRENST00000498586ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000430396ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000430396ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000430396ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000374087ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374087ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000374087ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000414907ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000414907ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000414907ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000344348ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000344348ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000344348ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3CDSENST00000374082ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3UTRENST00000374082ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
intron-3UTRENST00000374082ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+
In-frameENST00000443446ENST00000358559NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000443446ENST00000474170NCOA4chr10

51585599

+MSMBchr10

51555731

+
5CDS-3UTRENST00000443446ENST00000298239NCOA4chr10

51585599

+MSMBchr10

51555731

+

Top

FusionProtFeatures for NCOA4_MSMB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA4

Q13772

MSMB

P08118

Enhances the androgen receptor transcriptional activityin prostate cancer cells. Ligand-independent coactivator of theperoxisome proliferator-activated receptor (PPAR) gamma.{ECO:0000269|PubMed:10347167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA4_MSMB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NCOA4_MSMB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOA4AR, PPARG, ESR1, GTF2B, KAT2B, NR3C1, VDR, AKT1, ATXN2, RXRA, HERC2, XPO1, GRIA2, KDR, KIFC3, PSMC1, XRCC3, HUWE1, PSMD14, TFG, KIF21A, USP43, FTH1, FTL, GMCL1, NEURL4MSMBAPP, SGTA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NCOA4_MSMB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NCOA4_MSMB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA4C0040136Thyroid Neoplasm1CTD_human
TgeneMSMBC0033578Prostatic Neoplasms3CTD_human