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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2365

FusionGeneSummary for ARHGAP10_FBXW2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP10_FBXW2
Fusion gene ID: 2365
HgeneTgene
Gene symbol

ARHGAP10

FBXW2

Gene ID

79658

26190

Gene nameRho GTPase activating protein 10F-box and WD repeat domain containing 2
SynonymsGRAF2|PS-GAP|PSGAPFBW2|Fwd2|Md6
Cytomap

4q31.23

9q33.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10F-box/WD repeat-containing protein 2F-box and WD-40 domain protein 2F-box and WD-40 domain-containing protein 2
Modification date2018052320180522
UniProtAcc

A1A4S6

Q9UKT8

Ensembl transtripts involved in fusion geneENST00000336498, ENST00000414545, 
ENST00000510076, 
ENST00000493559, 
ENST00000608872, ENST00000340778, 
Fusion gene scores* DoF score4 X 5 X 5=1003 X 3 X 2=18
# samples 63
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGAP10 [Title/Abstract] AND FBXW2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8IG-01AARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336498ENST00000493559ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
5CDS-intronENST00000336498ENST00000608872ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
5CDS-intronENST00000336498ENST00000340778ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
5CDS-intronENST00000414545ENST00000493559ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
5CDS-intronENST00000414545ENST00000608872ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
5CDS-intronENST00000414545ENST00000340778ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
intron-intronENST00000510076ENST00000493559ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
intron-intronENST00000510076ENST00000608872ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-
intron-intronENST00000510076ENST00000340778ARHGAP10chr4

148993926

+FBXW2chr9

123550464

-

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FusionProtFeatures for ARHGAP10_FBXW2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP10

A1A4S6

FBXW2

Q9UKT8

GTPase activator for the small GTPases RhoA and Cdc42 byconverting them to an inactive GDP-bound state. Essential forPTKB2 regulation of cytoskeletal organization via Rho familyGTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinaseactivity and changes its localization from the nucleus to theperinuclear region. Stabilizes PAK-2p34 thereby increasingstimulation of cell death (By similarity). {ECO:0000250,ECO:0000269|PubMed:11432776}. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP10_FBXW2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP10_FBXW2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP10PKN3, RHOA, CDC42, YWHAQ, C2CD2, SH3BP2, ANKS1A, FOXQ1, PTPN12, ARHGAP26, NRXN1, ARF6FBXW2CUL1, SKP1, UBE2D2, CDC34, GCM1, FBXW8, RBX1, REST, BTG1, BTG2, HSP90AA1, GNB2L1, FBXO6, EP300, FBXO17, SPANXN3, FBXO7, BTRC, SKP2, ARIH1, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP10_FBXW2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP10_FBXW2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource