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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23649

FusionGeneSummary for NCOA2_CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA2_CAPZB
Fusion gene ID: 23649
HgeneTgene
Gene symbol

NCOA2

CAPZB

Gene ID

10499

832

Gene namenuclear receptor coactivator 2capping actin protein of muscle Z-line subunit beta
SynonymsGRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75CAPB|CAPPB|CAPZ
Cytomap

8q13.3

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, beta
Modification date2018052320180523
UniProtAcc

Q15596

P47756

Ensembl transtripts involved in fusion geneENST00000452400, ENST00000267974, 
ENST00000524223, 
ENST00000401084, 
ENST00000264203, ENST00000375142, 
ENST00000433834, ENST00000264202, 
ENST00000482808, ENST00000375144, 
Fusion gene scores* DoF score19 X 13 X 8=19768 X 11 X 4=352
# samples 2113
** MAII scorelog2(21/1976*10)=-3.23412171391855
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/352*10)=-1.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOA2 [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL706656NCOA2chr8

71290981

-CAPZBchr1

19672964

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000452400ENST00000401084NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000264203NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000375142NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000433834NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000264202NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000482808NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000452400ENST00000375144NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000401084NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000264203NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000375142NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000433834NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000264202NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000482808NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000267974ENST00000375144NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000401084NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000264203NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000375142NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000433834NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000264202NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000482808NCOA2chr8

71290981

-CAPZBchr1

19672964

-
intron-intronENST00000524223ENST00000375144NCOA2chr8

71290981

-CAPZBchr1

19672964

-

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FusionProtFeatures for NCOA2_CAPZB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA2

Q15596

CAPZB

P47756

Transcriptional coactivator for steroid receptors andnuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Requiredwith NCOA1 to control energy balance between white and brownadipose tissues. Critical regulator of glucose metabolismregulation, acts as RORA coactivator to specifically modulate G6PCexpression. Involved in the positive regulation of thetranscriptional activity of the glucocorticoid receptor NR3C1 bysumoylation enhancer RWDD3. Positively regulates the circadianclock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).{ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108,ECO:0000269|PubMed:9430642}. F-actin-capping proteins bind in a Ca(2+)-independentmanner to the fast growing ends of actin filaments (barbed end)thereby blocking the exchange of subunits at these ends. Unlikeother capping proteins (such as gelsolin and severin), theseproteins do not sever actin filaments. Plays a role in theregulation of cell morphology and cytoskeletal organization.{ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA2_CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOA2_CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOA2_CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNCOA2Q15596DB00255DiethylstilbestrolNuclear receptor coactivator 2small moleculeapproved|investigational
HgeneNCOA2Q15596DB00783EstradiolNuclear receptor coactivator 2small moleculeapproved|investigational|vet_approved

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RelatedDiseases for NCOA2_CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA2C0033578Prostatic Neoplasms1CTD_human
HgeneNCOA2C1458155Mammary Neoplasms1CTD_human
TgeneCAPZBC0024667Animal Mammary Neoplasms1CTD_human
TgeneCAPZBC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCAPZBC0948089Acute Coronary Syndrome1CTD_human