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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23647

FusionGeneSummary for NCOA1_UBXN2A

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA1_UBXN2A
Fusion gene ID: 23647
HgeneTgene
Gene symbol

NCOA1

UBXN2A

Gene ID

8648

165324

Gene namenuclear receptor coactivator 1UBX domain protein 2A
SynonymsF-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74UBXD4
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1UBX domain-containing protein 2AUBX domain containing 4UBX domain-containing protein 4
Modification date2018052320180523
UniProtAcc

Q15788

P68543

Ensembl transtripts involved in fusion geneENST00000406961, ENST00000469850, 
ENST00000405141, ENST00000407230, 
ENST00000538539, ENST00000288599, 
ENST00000348332, ENST00000395856, 
ENST00000446425, ENST00000404924, 
ENST00000309033, ENST00000535786, 
Fusion gene scores* DoF score10 X 9 X 6=5404 X 2 X 5=40
# samples 116
** MAII scorelog2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA1 [Title/Abstract] AND UBXN2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

HgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

HgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

HgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-A4JB-01ANCOA1chr2

24807429

+UBXN2Achr2

24181171

+
TCGARVSKCMTCGA-D3-A1Q6-06ANCOA1chr2

24920667

+UBXN2Achr2

24222542

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000406961ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000406961ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000406961ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000406961ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
intron-3UTRENST00000469850ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
intron-5UTRENST00000469850ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
intron-5UTRENST00000469850ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
intron-5UTRENST00000469850ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000405141ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000405141ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000405141ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000405141ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000407230ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000407230ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000407230ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000407230ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000538539ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000538539ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000538539ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000538539ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000288599ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000288599ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000288599ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000288599ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000348332ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000348332ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000348332ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000348332ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-3UTRENST00000395856ENST00000446425NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000395856ENST00000404924NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000395856ENST00000309033NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5UTR-5UTRENST00000395856ENST00000535786NCOA1chr2

24807429

+UBXN2Achr2

24181171

+
5CDS-3UTRENST00000406961ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000406961ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000406961ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000406961ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
intron-3UTRENST00000469850ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
intron-3UTRENST00000469850ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
intron-3UTRENST00000469850ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
intron-3UTRENST00000469850ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000405141ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000405141ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000405141ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000405141ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000407230ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000407230ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000407230ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000407230ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000538539ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000538539ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000538539ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000538539ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000288599ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000288599ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000288599ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000288599ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000348332ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000348332ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000348332ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000348332ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000395856ENST00000446425NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000395856ENST00000404924NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000395856ENST00000309033NCOA1chr2

24920667

+UBXN2Achr2

24222542

+
5CDS-3UTRENST00000395856ENST00000535786NCOA1chr2

24920667

+UBXN2Achr2

24222542

+

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FusionProtFeatures for NCOA1_UBXN2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA1

Q15788

UBXN2A

P68543


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOA1_UBXN2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOA1_UBXN2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOA1NR1H4, FOS, JUN, NFKB1, AR, CIITA, NR1I2, SMARCE1, BCL3, NR3C1, YWHAQ, STAT6, TRIP4, ESR1, SMARCA4, CREBBP, KAT2B, PRMT1, NR4A1, PPARA, NCOR1, FOXA2, RARB, GTF2B, TBP, TEAD2, TEAD1, STAT3, HNF4A, HIF1A, NR5A1, CCND1, ESRRG, ESR2, PGR, THRB, NCOA2, TRIM21, NR2F6, PPARGC1A, SNW1, RXRA, STAT5A, CARM1, NKX2-1, PPARG, NCOA3, VDR, THRA, RARA, EP300, RBBP6, RARG, PPARD, RORA, NCOA6, TP53, UBE2L3, COPS5, NCOA1, ANIB1, TRIM24, KANK2, AHR, CXADR, PAGR1, RORB, HNF4G, ESRRA, NR5A2, NR6A1, ASCC1, RABGGTB, NR1I3, ARID1A, EZH2, BRCA1, NR1H2, NR1H3, RXRB, SRF, HNF1A, NR3C2, FOXO1, RNF4, ARNT, ETS2, ETS1, SMARCC1, SF1, WDHD1, SYTL2, HSPA2, HSPA5, KCTD3, VCP, ITCH, TRIP11, UBR5, SMAD3, ANKRD11, NR4A2, FAM131B, C19orf57, PLA2G10, TRPC4AP, SLX1AUBXN2AVCPIP1, VCP, PHAX, DBI, UBXN6, MYH11, PPP1CB, LIMA1, PPP1R7, HSPA9, ASPSCR1, PPP1R11, LACTB, MYLPF, NSFL1C, PPP1CA, UBXN10, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOA1_UBXN2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOA1_UBXN2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA1C0014175Endometriosis1CTD_human
HgeneNCOA1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneNCOA1C0027627Neoplasm Metastasis1CTD_human
HgeneNCOA1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOA1C1458155Mammary Neoplasms1CTD_human