FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23645

FusionGeneSummary for NCOA1_NOVA1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA1_NOVA1
Fusion gene ID: 23645
HgeneTgene
Gene symbol

NCOA1

NOVA1

Gene ID

8648

4857

Gene namenuclear receptor coactivator 1NOVA alternative splicing regulator 1
SynonymsF-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74Nova-1
Cytomap

2p23.3

14q12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1RNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1
Modification date2018052320180519
UniProtAcc

Q15788

P51513

Ensembl transtripts involved in fusion geneENST00000406961, ENST00000469850, 
ENST00000405141, ENST00000407230, 
ENST00000538539, ENST00000288599, 
ENST00000348332, ENST00000395856, 
ENST00000465357, ENST00000539517, 
ENST00000267422, ENST00000344429, 
ENST00000547619, ENST00000574031, 
ENST00000551754, 
Fusion gene scores* DoF score10 X 9 X 6=5404 X 3 X 3=36
# samples 114
** MAII scorelog2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOA1 [Title/Abstract] AND NOVA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

HgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

HgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

HgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX099622NCOA1chr2

24991843

+NOVA1chr14

27066939

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000406961ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-5UTRENST00000406961ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000406961ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000406961ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000406961ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000406961ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000406961ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-5UTRENST00000469850ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000469850ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-5UTRENST00000405141ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000405141ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-5UTRENST00000407230ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000407230ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-5UTRENST00000538539ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
intron-intronENST00000538539ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-5UTRENST00000288599ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000288599ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-5UTRENST00000348332ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000348332ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000465357NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-5UTRENST00000395856ENST00000539517NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000267422NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000344429NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000547619NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000574031NCOA1chr2

24991843

+NOVA1chr14

27066939

-
3UTR-intronENST00000395856ENST00000551754NCOA1chr2

24991843

+NOVA1chr14

27066939

-

Top

FusionProtFeatures for NCOA1_NOVA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA1

Q15788

NOVA1

P51513

May regulate RNA splicing or metabolism in a specificsubset of developing neurons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NCOA1_NOVA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NCOA1_NOVA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NCOA1_NOVA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NCOA1_NOVA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOA1C0014175Endometriosis1CTD_human
HgeneNCOA1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneNCOA1C0027627Neoplasm Metastasis1CTD_human
HgeneNCOA1C0033578Prostatic Neoplasms1CTD_human
HgeneNCOA1C1458155Mammary Neoplasms1CTD_human