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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23629

FusionGeneSummary for NCL_NPY

check button Fusion gene summary
Fusion gene informationFusion gene name: NCL_NPY
Fusion gene ID: 23629
HgeneTgene
Gene symbol

NCL

NPY

Gene ID

80331

4852

Gene nameDnaJ heat shock protein family (Hsp40) member C5neuropeptide Y
SynonymsCLN4|CLN4B|CSP|DNAJC5A|NCL|mir-941-2|mir-941-3|mir-941-4|mir-941-5PYY4
Cytomap

20q13.33

7p15.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 5DnaJ (Hsp40) homolog, subfamily C, member 5ceroid-lipofuscinosis neuronal protein 4cysteine string protein alphapro-neuropeptide Yprepro-neuropeptide Y
Modification date2018052220180527
UniProtAcc

P19338

P01303

Ensembl transtripts involved in fusion geneENST00000322723, ENST00000242152, 
ENST00000407573, ENST00000405982, 
Fusion gene scores* DoF score18 X 18 X 6=19445 X 5 X 4=100
# samples 225
** MAII scorelog2(22/1944*10)=-3.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCL [Title/Abstract] AND NPY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV718213NCLchr2

232323022

-NPYchr7

24331284

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000322723ENST00000242152NCLchr2

232323022

-NPYchr7

24331284

+
intron-3CDSENST00000322723ENST00000407573NCLchr2

232323022

-NPYchr7

24331284

+
intron-3CDSENST00000322723ENST00000405982NCLchr2

232323022

-NPYchr7

24331284

+

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FusionProtFeatures for NCL_NPY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCL

P19338

NPY

P01303

Nucleolin is the major nucleolar protein of growingeukaryotic cells. It is found associated with intranucleolarchromatin and pre-ribosomal particles. It induces chromatindecondensation by binding to histone H1. It is thought to play arole in pre-rRNA transcription and ribosome assembly. May play arole in the process of transcriptional elongation. Binds RNAoligonucleotides with 5'-UUAGGG-3' repeats more tightly than thetelomeric single-stranded DNA 5'-TTAGGG-3' repeats.{ECO:0000269|PubMed:10393184}. NPY is implicated in the control of feeding and insecretion of gonadotrophin-release hormone.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCL_NPY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCL_NPY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCL_NPY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCL_NPY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCLC0151744Myocardial Ischemia1CTD_human
TgeneNPYC0011581Depressive disorder7CTD_human;PSYGENET
TgeneNPYC0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
TgeneNPYC0011570Mental Depression5PSYGENET
TgeneNPYC0041696Unipolar Depression5PSYGENET
TgeneNPYC0525045Mood Disorders5PSYGENET
TgeneNPYC1269683Major Depressive Disorder5PSYGENET
TgeneNPYC0003123Anorexia3CTD_human
TgeneNPYC0036572Seizures3CTD_human
TgeneNPYC0014544Epilepsy2CTD_human
TgeneNPYC0036341Schizophrenia2PSYGENET
TgeneNPYC0085762Alcohol abuse2PSYGENET
TgeneNPYC0002395Alzheimer's Disease1CTD_human
TgeneNPYC0003469Anxiety Disorders1CTD_human
TgeneNPYC0004096Asthma1CTD_human
TgeneNPYC0007222Cardiovascular Diseases1CTD_human
TgeneNPYC0007785Cerebral Infarction1CTD_human
TgeneNPYC0008677Bronchitis, Chronic1CTD_human
TgeneNPYC0014556Epilepsy, Temporal Lobe1CTD_human
TgeneNPYC0020564Hypertrophy1CTD_human
TgeneNPYC0025261Memory Disorders1CTD_human
TgeneNPYC0026837Muscle Rigidity1CTD_human
TgeneNPYC0027429Nasal obstruction present finding1CTD_human
TgeneNPYC0031117Peripheral Neuropathy1CTD_human
TgeneNPYC0035455Rhinitis1CTD_human
TgeneNPYC0036337Schizoaffective Disorder1PSYGENET
TgeneNPYC0038587Substance Withdrawal Syndrome1CTD_human
TgeneNPYC0085159Seasonal Affective Disorder1PSYGENET
TgeneNPYC0236664Alcohol-Related Disorders1PSYGENET
TgeneNPYC0236736Cocaine-Related Disorders1CTD_human
TgeneNPYC0236969Substance-Related Disorders1CTD_human
TgeneNPYC0424295Hyperactive behavior1CTD_human
TgeneNPYC0600427Cocaine Dependence1PSYGENET
TgeneNPYC1262477Weight decreased1CTD_human
TgeneNPYC2362914clinical depression1PSYGENET