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Fusion gene ID: 23617 |
FusionGeneSummary for NCKIPSD_LPP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCKIPSD_LPP | Fusion gene ID: 23617 | Hgene | Tgene | Gene symbol | NCKIPSD | LPP | Gene ID | 51517 | 4026 |
| Gene name | NCK interacting protein with SH3 domain | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | AF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISH | - | |
| Cytomap | 3p21.31 | 3q27.3-q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NCK-interacting protein with SH3 domain54 kDa VacA-interacting protein54 kDa vimentin-interacting protein90 kDa SH3 protein interacting with NckSH3 adapter protein SPIN90SH3 protein interacting with Nck, 90 kDaWASP-interacting SH3-domain proteindia | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9NZQ3 | Q93052 | |
| Ensembl transtripts involved in fusion gene | ENST00000341520, ENST00000416649, ENST00000294129, | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 12 X 17 X 5=1020 |
| # samples | 3 | 20 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/1020*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCKIPSD [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC026280 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000341520 | ENST00000448637 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| intron-intron | ENST00000341520 | ENST00000312675 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| intron-intron | ENST00000341520 | ENST00000543006 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| intron-intron | ENST00000341520 | ENST00000471917 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000416649 | ENST00000448637 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000416649 | ENST00000312675 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000416649 | ENST00000543006 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000416649 | ENST00000471917 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000294129 | ENST00000448637 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000294129 | ENST00000312675 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000294129 | ENST00000543006 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
| 5CDS-intron | ENST00000294129 | ENST00000471917 | NCKIPSD | chr3 | 48711281 | - | LPP | chr3 | 188227681 | - |
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FusionProtFeatures for NCKIPSD_LPP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCKIPSD | LPP |
| Has an important role in stress fiber formation inducedby active diaphanous protein homolog 1 (DRF1). Induces microspikeformation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (Bysimilarity). May play an important role in the maintenance ofsarcomeres and/or in the assembly of myofibrils into sarcomeres.Implicated in regulation of actin polymerization and celladhesion. Plays a role in angiogenesis. {ECO:0000250,ECO:0000269|PubMed:22419821}. | May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCKIPSD_LPP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCKIPSD_LPP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCKIPSD_LPP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCKIPSD_LPP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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