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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23616

FusionGeneSummary for NCKIPSD_IP6K2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCKIPSD_IP6K2
Fusion gene ID: 23616
HgeneTgene
Gene symbol

NCKIPSD

IP6K2

Gene ID

51517

51447

Gene nameNCK interacting protein with SH3 domaininositol hexakisphosphate kinase 2
SynonymsAF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISHIHPK2|PIUS
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionNCK-interacting protein with SH3 domain54 kDa VacA-interacting protein54 kDa vimentin-interacting protein90 kDa SH3 protein interacting with NckSH3 adapter protein SPIN90SH3 protein interacting with Nck, 90 kDaWASP-interacting SH3-domain proteindiainositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulator
Modification date2018052220180519
UniProtAcc

Q9NZQ3

Q9UHH9

Ensembl transtripts involved in fusion geneENST00000341520, ENST00000416649, 
ENST00000294129, 
ENST00000328631, 
ENST00000340879, ENST00000432678, 
ENST00000431721, ENST00000449610, 
ENST00000413298, ENST00000450045, 
ENST00000446860, ENST00000417896, 
ENST00000443964, ENST00000436134, 
ENST00000453202, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 5 X 3=75
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCKIPSD [Title/Abstract] AND IP6K2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIP6K2

GO:0046854

phosphatidylinositol phosphorylation

10574768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-UC-A7PF-01ANCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000341520ENST00000328631NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000340879NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000432678NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000431721NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000449610NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000413298NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000450045NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000446860NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000417896NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000443964NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000436134NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000341520ENST00000453202NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000328631NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000340879NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000432678NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000431721NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000449610NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000413298NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000450045NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000446860NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000417896NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000443964NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000436134NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000416649ENST00000453202NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000328631NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000340879NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000432678NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000431721NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000449610NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000413298NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000450045NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000446860NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000417896NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000443964NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000436134NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000294129ENST00000453202NCKIPSDchr3

48715997

-IP6K2chr3

48732854

-

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FusionProtFeatures for NCKIPSD_IP6K2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCKIPSD

Q9NZQ3

IP6K2

Q9UHH9

Has an important role in stress fiber formation inducedby active diaphanous protein homolog 1 (DRF1). Induces microspikeformation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (Bysimilarity). May play an important role in the maintenance ofsarcomeres and/or in the assembly of myofibrils into sarcomeres.Implicated in regulation of actin polymerization and celladhesion. Plays a role in angiogenesis. {ECO:0000250,ECO:0000269|PubMed:22419821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCKIPSD_IP6K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCKIPSD_IP6K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCKIPSDDMRTB1, BAIAP2, NCK2, DIAPH3, GRB2, NCK1, STAC, KHDRBS1, FASLG, CRK, YWHAB, PSMD9, SORBS3, HSPB1, CNTROB, XPO1, CAPZA2, CSNK2A2, IQGAP1, FGFR1OP, LRIF1, SMC6, FCHSD1, ITSN2, PALLD, GAS7, ARHGEF6, GIT1, GIT2, ARHGEF7, ZFYVE9, PLCG1, ITSN1, RAB11FIP5, EPS15L1, GEMIN8, SNX33, RBM15, USP9Y, RBM15B, DACH1, GEMIN6, GEMIN2, CSNK1A1, JUN, ARMC8, PDCD2L, FBXO28IP6K2PLSCR1, GABRR1, TRAF2, HSP90AA1, HSP90AB1, MEOX2, RBPMS, GTPBP6, UNK, LNX2, PGK2, RHOU, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCKIPSD_IP6K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCKIPSD_IP6K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIP6K2C0020179Huntington Disease1CTD_human