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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23614

FusionGeneSummary for NCKAP5_SLIT3

check button Fusion gene summary
Fusion gene informationFusion gene name: NCKAP5_SLIT3
Fusion gene ID: 23614
HgeneTgene
Gene symbol

NCKAP5

SLIT3

Gene ID

344148

6586

Gene nameNCK associated protein 5slit guidance ligand 3
SynonymsERIH1|ERIH2|NAP5MEGF5|SLIL2|SLIT1|Slit-3|slit2
Cytomap

2q21.2

5q34-q35.1

Type of geneprotein-codingprotein-coding
Descriptionnck-associated protein 5NAP-5peripheral clock protein 2slit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3
Modification date2018051920180522
UniProtAcc

O14513

O75094

Ensembl transtripts involved in fusion geneENST00000409261, ENST00000409213, 
ENST00000405974, ENST00000317721, 
ENST00000473859, 		ENST00000519560, 
ENST00000332966, ENST00000404867, 
ENST00000521130, 
Fusion gene scores* DoF score10 X 7 X 7=4904 X 4 X 4=64
# samples 114
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCKAP5 [Title/Abstract] AND SLIT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLIT3

GO:0007411

axon guidance

11748139

TgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

TgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

TgeneSLIT3

GO:0050919

negative chemotaxis

11748139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV413004NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409261ENST00000519560NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409261ENST00000332966NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409261ENST00000404867NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409261ENST00000521130NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409213ENST00000519560NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409213ENST00000332966NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409213ENST00000404867NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000409213ENST00000521130NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000405974ENST00000519560NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000405974ENST00000332966NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000405974ENST00000404867NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000405974ENST00000521130NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000317721ENST00000519560NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000317721ENST00000332966NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000317721ENST00000404867NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000317721ENST00000521130NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000473859ENST00000519560NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000473859ENST00000332966NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000473859ENST00000404867NCKAP5chr2

134193555

+SLIT3chr5

168577147

-
intron-intronENST00000473859ENST00000521130NCKAP5chr2

134193555

+SLIT3chr5

168577147

-

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FusionProtFeatures for NCKAP5_SLIT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCKAP5

O14513

SLIT3

O75094

May act as molecular guidance cue in cellular migration,and function may be mediated by interaction with roundabouthomolog receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCKAP5_SLIT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCKAP5_SLIT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCKAP5_SLIT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCKAP5_SLIT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCKAP5C0086132Depressive Symptoms1PSYGENET
TgeneSLIT3C0019284Diaphragmatic Hernia1CTD_human
TgeneSLIT3C0036341Schizophrenia1PSYGENET
TgeneSLIT3C0041696Unipolar Depression1PSYGENET
TgeneSLIT3C1269683Major Depressive Disorder1PSYGENET