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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2361

FusionGeneSummary for ARGLU1_LPIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARGLU1_LPIN1
Fusion gene ID: 2361
HgeneTgene
Gene symbol

ARGLU1

LPIN1

Gene ID

55082

23175

Gene namearginine and glutamate rich 1lipin 1
Synonyms-PAP1
Cytomap

13q33.3

2p25.1

Type of geneprotein-codingprotein-coding
Descriptionarginine and glutamate-rich protein 1phosphatidate phosphatase LPIN1
Modification date2018052220180523
UniProtAcc

Q9NWB6

Q14693

Ensembl transtripts involved in fusion geneENST00000400198, ENST00000472226, 
ENST00000375926, 
ENST00000449576, 
ENST00000396099, ENST00000425416, 
ENST00000256720, ENST00000396097, 
ENST00000404113, ENST00000464517, 
ENST00000396098, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 6 X 3=108
# samples 58
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARGLU1 [Title/Abstract] AND LPIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF365751ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
ChiTaRS3.1AW889856ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000400198ENST00000449576ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000396099ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000425416ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000256720ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000396097ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000404113ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000464517ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000400198ENST00000396098ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000449576ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000396099ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000425416ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000256720ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000396097ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000404113ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000464517ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000472226ENST00000396098ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000449576ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000396099ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000425416ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000256720ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000396097ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000404113ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000464517ARGLU1chr13

107210889

+LPIN1chr2

11938938

+
intron-intronENST00000375926ENST00000396098ARGLU1chr13

107210889

+LPIN1chr2

11938938

+

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FusionProtFeatures for ARGLU1_LPIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARGLU1

Q9NWB6

LPIN1

Q14693

Required for the estrogen-dependent expression of ESR1target genes. Can act in cooperation with MED1.{ECO:0000269|PubMed:21454576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARGLU1_LPIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARGLU1_LPIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARGLU1_LPIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARGLU1_LPIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource