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Fusion gene ID: 23608 |
FusionGeneSummary for NCKAP5_DYNC2H1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCKAP5_DYNC2H1 | Fusion gene ID: 23608 | Hgene | Tgene | Gene symbol | NCKAP5 | DYNC2H1 | Gene ID | 344148 | 79659 |
| Gene name | NCK associated protein 5 | dynein cytoplasmic 2 heavy chain 1 | |
| Synonyms | ERIH1|ERIH2|NAP5 | ATD3|DHC1b|DHC2|DNCH2|DYH1B|SRPS2B|SRTD3|hdhc11 | |
| Cytomap | 2q21.2 | 11q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nck-associated protein 5NAP-5peripheral clock protein 2 | cytoplasmic dynein 2 heavy chain 1dynein cytoplasmic heavy chain 2dynein heavy chain 11dynein heavy chain, isotype 1Bdynein, cytoplasmic, heavy polypeptide 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O14513 | Q8NCM8 | |
| Ensembl transtripts involved in fusion gene | ENST00000409261, ENST00000409213, ENST00000405974, ENST00000317721, ENST00000473859, | ENST00000375735, ENST00000334267, ENST00000398093, | |
| Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 9 X 8 X 7=504 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/490*10)=-2.15527822547791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCKAP5 [Title/Abstract] AND DYNC2H1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DYNC2H1 | GO:0007030 | Golgi organization | 8666668 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-FG-5963-01A | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| TCGA | RV | LGG | TCGA-FG-5963-02A | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000409261 | ENST00000375735 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| Frame-shift | ENST00000409261 | ENST00000334267 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| Frame-shift | ENST00000409261 | ENST00000398093 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| Frame-shift | ENST00000409213 | ENST00000375735 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| Frame-shift | ENST00000409213 | ENST00000334267 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| Frame-shift | ENST00000409213 | ENST00000398093 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000405974 | ENST00000375735 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000405974 | ENST00000334267 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000405974 | ENST00000398093 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000317721 | ENST00000375735 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000317721 | ENST00000334267 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| In-frame | ENST00000317721 | ENST00000398093 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| intron-3CDS | ENST00000473859 | ENST00000375735 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| intron-3CDS | ENST00000473859 | ENST00000334267 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
| intron-3CDS | ENST00000473859 | ENST00000398093 | NCKAP5 | chr2 | 133971288 | - | DYNC2H1 | chr11 | 103306671 | + |
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FusionProtFeatures for NCKAP5_DYNC2H1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCKAP5 | DYNC2H1 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCKAP5_DYNC2H1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_255aa MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMCPLAWQSKWEGPEDPLQYLRG LVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_1375nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC CAGTGGATTCAGTGTGGAGCAGCTCTATTCCTAAAAAATCAGTAGAATCTAATGACAACAAAAGCCATCTTCACAAAAGGGAACATTGAT TCTTTAAGCTTTAAATCAAACATGTGGTCAGTCTACATTTGAAATGTTAGTTCAAAATATTAACATATAGTTATGTTGTTGATGTCACTG AAATTTTAATGTGTAAAAGCAGCACTGTGCATCTTTTAAAGTAATAAATTAATGGAGTTATTGTTAAAACAGAGTATTCTTTTGACAACA TTAAATATTTCTGTGAGAAAGTTCACTTTTCCAGTGGCTCAAAAATTTGTTTTAGGTCAGAGATTTTAAGTGGTATATTAACCAATAATA AATATTTTGGCTGTCATTTGTGTCATAATTATTTAATAAAAGAGCATTCATAATTTTTGCAGTCTTCCCATGACTCTTTTTACATACTGA AGAATGTATTATAAAGTTATAATGAATGTATAAAAGTATCAACATGAATATAATTATACTATGCTAATTATAATATACAAATATATAATT ATTGTCATAATTATATACTTATAACTAATATCTTAAGGTAATTCAAATAGGAATAATTCAGGTGACATAATAATGGAGGATAAATTCTGG >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_933nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC CAGTGGATTCAGTGTGGAGCAGCTCTATTCCTAAAAAATCAGTAGAATCTAATGACAACAAAAGCCATCTTCACAAAAGGGAACATTGAT TCTTTAAGCTTTAAATCAAACATGTGGTCAGTCTACATTTGAAATGTTAGTTCAAAATATTAACATATAGTTATGTTGTTGATGTCACTG >In-frame_NCKAP5_ENST00000405974_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000375735_chr11_103306671_+_1375nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC CAGTGGATTCAGTGTGGAGCAGCTCTATTCCTAAAAAATCAGTAGAATCTAATGACAACAAAAGCCATCTTCACAAAAGGGAACATTGAT TCTTTAAGCTTTAAATCAAACATGTGGTCAGTCTACATTTGAAATGTTAGTTCAAAATATTAACATATAGTTATGTTGTTGATGTCACTG AAATTTTAATGTGTAAAAGCAGCACTGTGCATCTTTTAAAGTAATAAATTAATGGAGTTATTGTTAAAACAGAGTATTCTTTTGACAACA TTAAATATTTCTGTGAGAAAGTTCACTTTTCCAGTGGCTCAAAAATTTGTTTTAGGTCAGAGATTTTAAGTGGTATATTAACCAATAATA AATATTTTGGCTGTCATTTGTGTCATAATTATTTAATAAAAGAGCATTCATAATTTTTGCAGTCTTCCCATGACTCTTTTTACATACTGA AGAATGTATTATAAAGTTATAATGAATGTATAAAAGTATCAACATGAATATAATTATACTATGCTAATTATAATATACAAATATATAATT ATTGTCATAATTATATACTTATAACTAATATCTTAAGGTAATTCAAATAGGAATAATTCAGGTGACATAATAATGGAGGATAAATTCTGG >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000334267_chr11_103306671_+_933nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC CAGTGGATTCAGTGTGGAGCAGCTCTATTCCTAAAAAATCAGTAGAATCTAATGACAACAAAAGCCATCTTCACAAAAGGGAACATTGAT TCTTTAAGCTTTAAATCAAACATGTGGTCAGTCTACATTTGAAATGTTAGTTCAAAATATTAACATATAGTTATGTTGTTGATGTCACTG >In-frame_NCKAP5_ENST00000317721_chr2_133971288_-_DYNC2H1_ENST00000398093_chr11_103306671_+_765nt ATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACATGGACTCCAATAAA TACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGACTACAGCGAGAAGTT GCCCAAAGAACAAGTGAGGGGGCCATGTGTCCTCTCGCATGGCAGAGCAAGTGGGAAGGCCCAGAAGATCCCTTACAATACCTGAGAGGT CTTGTTGCCCGTGCCCTTGCAATACAGAACTGGGTAGATAAAGCTGAAAAACAGGCTCTTCTCTCTGAAACACTTGACCTATCAGAACTT TTCCATCCAGACACATTTCTTAATGCTCTTCGCCAGGAAACTGCAAGGGCAGTGGGTCGTTCTGTGGATAGCCTTAAATTTGTAGCCTCA TGGAAAGGTCGACTGCAAGAAGCAAAGCTACAAATTAAGATCAGTGGCTTGTTACTAGAAGGATGTAGTTTTGATGGAAATCAACTTTCT GAAAATCAGCTTGATTCTCCCAGCGTGTCATCAGTGCTCCCTTGTTTTATGGGCTGGATTCCACAGGATGCATGTGGTCCATATTCTCCG GATGAGTGCATCTCTTTGCCTGTTTACACAAGTGCTGAAAGGGATCGTGTGGTTACCAATATTGATGTTCCATGTGGGGGCAACCAAGAC |
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FusionGenePPI for NCKAP5_DYNC2H1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NCKAP5 | APC, VAV2, HECW2 | DYNC2H1 | DYNC2LI1, USP50, PAXIP1, PEX14, FAM160B2, ARHGAP25, NONO, RUVBL2, GDI1, TIGD6, SPC24, PPP2R3C, GAN, EPHA1, FCGRT, CRYL1, MOCS3, IL17RA, KIAA1919, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCKAP5_DYNC2H1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCKAP5_DYNC2H1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NCKAP5 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
| Tgene | DYNC2H1 | C0036069 | Saldino-Noonan Syndrome | 4 | UNIPROT |
| Tgene | DYNC2H1 | C0036996 | Short Rib-Polydactyly Syndrome | 1 | CTD_human |
| Tgene | DYNC2H1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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