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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23592

FusionGeneSummary for NCK2_DDI2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCK2_DDI2
Fusion gene ID: 23592
HgeneTgene
Gene symbol

NCK2

DDI2

Gene ID

8440

84301

Gene nameNCK adaptor protein 2DNA damage inducible 1 homolog 2
SynonymsGRB4|NCKbeta-
Cytomap

2q12.2

1p36.21

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic protein NCK2SH2/SH3 adaptor protein NCK-betagrowth factor receptor-bound protein 4noncatalytic region of tyrosine kinase, betaprotein DDI1 homolog 2DDI1, DNA-damage inducible 1, homolog 2DNA-damage inducible protein 2 (DDI2)
Modification date2018052220180519
UniProtAcc

O43639

Q5TDH0

Ensembl transtripts involved in fusion geneENST00000233154, ENST00000451463, 
ENST00000522586, ENST00000393349, 
ENST00000480945, 
Fusion gene scores* DoF score6 X 4 X 5=1203 X 3 X 2=18
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCK2 [Title/Abstract] AND DDI2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCK2

GO:0033137

negative regulation of peptidyl-serine phosphorylation

16835242

HgeneNCK2

GO:0045944

positive regulation of transcription by RNA polymerase II

10026169

HgeneNCK2

GO:1903912

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

16835242

TgeneDDI2

GO:0016485

protein processing

27528193


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF333117NCK2chr2

106429034

-DDI2chr1

15964848

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000233154ENST00000480945NCK2chr2

106429034

-DDI2chr1

15964848

+
intron-3CDSENST00000451463ENST00000480945NCK2chr2

106429034

-DDI2chr1

15964848

+
intron-3CDSENST00000522586ENST00000480945NCK2chr2

106429034

-DDI2chr1

15964848

+
intron-3CDSENST00000393349ENST00000480945NCK2chr2

106429034

-DDI2chr1

15964848

+

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FusionProtFeatures for NCK2_DDI2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCK2

O43639

DDI2

Q5TDH0

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellularsubstrates. Maintains low levels of EIF2S1 phosphorylation bypromoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Rassignaling. {ECO:0000269|PubMed:10026169,ECO:0000269|PubMed:16835242}. Aspartic protease that mediates the cleavage ofNFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1from the endoplasmic reticulum membrane (PubMed:27676298,PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisitefor cleavage, suggesting that DDI2 specifically recognizes andbinds ubiquitinated NFE2L1/NRF1 (PubMed:27528193).{ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCK2_DDI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCK2_DDI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCK2_DDI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCK2_DDI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCK2C0001925Albuminuria1CTD_human
HgeneNCK2C0027726Nephrotic Syndrome1CTD_human
HgeneNCK2C0033687Proteinuria1CTD_human