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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23551

FusionGeneSummary for NCAM2_PAWR

check button Fusion gene summary
Fusion gene informationFusion gene name: NCAM2_PAWR
Fusion gene ID: 23551
HgeneTgene
Gene symbol

NCAM2

PAWR

Gene ID

4685

5074

Gene nameneural cell adhesion molecule 2pro-apoptotic WT1 regulator
SynonymsNCAM21PAR4|Par-4
Cytomap

21q21.1

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionneural cell adhesion molecule 2N-CAM-2NCAM-2PRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4
Modification date2018052320180523
UniProtAcc

O15394

Q96IZ0

Ensembl transtripts involved in fusion geneENST00000400546, ENST00000284894, 
ENST00000535285, ENST00000486367, 
ENST00000328827, ENST00000547571, 
Fusion gene scores* DoF score9 X 4 X 5=1808 X 6 X 5=240
# samples 98
** MAII scorelog2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCAM2 [Title/Abstract] AND PAWR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A7EI-01ANCAM2chr21

22746333

+PAWRchr12

80062188

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000400546ENST00000328827NCAM2chr21

22746333

+PAWRchr12

80062188

-
5CDS-5UTRENST00000400546ENST00000547571NCAM2chr21

22746333

+PAWRchr12

80062188

-
5CDS-intronENST00000284894ENST00000328827NCAM2chr21

22746333

+PAWRchr12

80062188

-
5CDS-5UTRENST00000284894ENST00000547571NCAM2chr21

22746333

+PAWRchr12

80062188

-
5CDS-intronENST00000535285ENST00000328827NCAM2chr21

22746333

+PAWRchr12

80062188

-
5CDS-5UTRENST00000535285ENST00000547571NCAM2chr21

22746333

+PAWRchr12

80062188

-
intron-intronENST00000486367ENST00000328827NCAM2chr21

22746333

+PAWRchr12

80062188

-
intron-5UTRENST00000486367ENST00000547571NCAM2chr21

22746333

+PAWRchr12

80062188

-

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FusionProtFeatures for NCAM2_PAWR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCAM2

O15394

PAWR

Q96IZ0

May play important roles in selective fasciculation andzone-to-zone projection of the primary olfactory axons. Pro-apoptopic protein capable of selectively inducingapoptosis in cancer cells, sensitizing the cells to diverseapoptotic stimuli and causing regression of tumors in animalmodels. Induces apoptosis in certain cancer cells by activation ofthe Fas prodeath pathway and coparallel inhibition of NF-kappa-Btranscriptional activity. Inhibits the transcriptional activationand augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction withWT1. Seems also to be a transcriptional repressor by itself. Maybe directly involved in regulating the amyloid precursor protein(APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCAM2_PAWR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCAM2_PAWR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCAM2QDPRPAWRTHAP1, SLC5A7, SLC5A1, AATF, DAPK3, PRKCZ, WT1, HSPA5, FBXO25, SPSB1, SPSB2, SPSB4, SQSTM1, DRD2, PAN2, APEH, CAND1, CARS, FAM129B, H3F3A, IDE, JMJD6, ATP6V1C1, SHMT1, PPM1G, SHMT2, SNX2, SNX6, STAT1, VPS29, FBXO45, CCDC8, EED, LUZP4, DDX39A, CEP290, CEP128, MYH9, HMG20A, IKBIP, SCOC, SLC25A41, G3BP1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCAM2_PAWR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCAM2_PAWR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAWRC0036341Schizophrenia2PSYGENET
TgenePAWRC0041696Unipolar Depression2PSYGENET
TgenePAWRC1269683Major Depressive Disorder2PSYGENET
TgenePAWRC0001418Adenocarcinoma1CTD_human
TgenePAWRC0005586Bipolar Disorder1PSYGENET
TgenePAWRC0014170Endometrial Neoplasms1CTD_human
TgenePAWRC0033578Prostatic Neoplasms1CTD_human
TgenePAWRC0033975Psychotic Disorders1PSYGENET
TgenePAWRC0525045Mood Disorders1PSYGENET
TgenePAWRC0600427Cocaine Dependence1PSYGENET