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Fusion gene ID: 2353 |
FusionGeneSummary for ARFGEF2_TSHZ2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARFGEF2_TSHZ2 | Fusion gene ID: 2353 | Hgene | Tgene | Gene symbol | ARFGEF2 | TSHZ2 | Gene ID | 10564 | 128553 |
| Gene name | ADP ribosylation factor guanine nucleotide exchange factor 2 | teashirt zinc finger homeobox 2 | |
| Synonyms | BIG2|PVNH2|dJ1164I10.1 | C20orf17|OVC10-2|TSH2|ZABC2|ZNF218 | |
| Cytomap | 20q13.13 | 20q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | brefeldin A-inhibited guanine nucleotide-exchange protein 2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)brefeldin A-inhibited GEP 2 | teashirt homolog 2cell growth-inhibiting protein 7ovarian cancer-related protein 10-2serologically defined colon cancer antigen 33 liketeashirt family zinc finger 2zinc finger protein 218 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6D5 | Q9NRE2 | |
| Ensembl transtripts involved in fusion gene | ENST00000371917, ENST00000493140, | ENST00000371497, ENST00000603338, ENST00000329613, | |
| Fusion gene scores | * DoF score | 9 X 6 X 4=216 | 22 X 6 X 8=1056 |
| # samples | 8 | 26 | |
| ** MAII score | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/1056*10)=-2.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARFGEF2 [Title/Abstract] AND TSHZ2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARFGEF2 | GO:0001881 | receptor recycling | 16477018 |
| Hgene | ARFGEF2 | GO:0035556 | intracellular signal transduction | 12571360 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A09D-01A | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371917 | ENST00000371497 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| In-frame | ENST00000371917 | ENST00000603338 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| Frame-shift | ENST00000371917 | ENST00000329613 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| intron-3CDS | ENST00000493140 | ENST00000371497 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| intron-3CDS | ENST00000493140 | ENST00000603338 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
| intron-3CDS | ENST00000493140 | ENST00000329613 | ARFGEF2 | chr20 | 47580435 | + | TSHZ2 | chr20 | 51870038 | + |
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FusionProtFeatures for ARFGEF2_TSHZ2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARFGEF2 | TSHZ2 |
| Promotes guanine-nucleotide exchange on ARF1 and ARF3and to a lower extent on ARF5 and ARF6. Promotes the activation ofARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved inthe regulation of Golgi vesicular transport. Required for theintegrity of the endosomal compartment. Involved in traffickingfrom the trans-Golgi network (TGN) to endosomes and is requiredfor membrane association of the AP-1 complex and GGA1. Seems to beinvolved in recycling of the transferrin receptor from recyclingendosomes to the plasma membrane. Probably is involved in the exitof GABA(A) receptors from the endoplasmic reticulum. Involved inconstitutive release of tumor necrosis factor receptor 1 viaexosome-like vesicles; the function seems to involve PKA andspecifically PRKAR2B. Proposed to act as A kinase-anchoringprotein (AKAP) and may mediate crosstalk between Arf and PKApathways. {ECO:0000269|PubMed:12051703,ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626,ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987,ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. | Probable transcriptional regulator involved indevelopmental processes. May act as a transcriptional repressor(Potential). {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 13_38 | 10 | 1032 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 13_38 | 13 | 3455 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 13_38 | 10 | 1012 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 841_911 | 10 | 1032 | DNA binding | Note=Homeobox%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 841_911 | 13 | 3455 | DNA binding | Note=Homeobox%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 841_911 | 10 | 1012 | DNA binding | Note=Homeobox%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 215_239 | 10 | 1032 | Zinc finger | C2H2-type 1 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 275_299 | 10 | 1032 | Zinc finger | C2H2-type 2 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 380_404 | 10 | 1032 | Zinc finger | C2H2-type 3%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 926_948 | 10 | 1032 | Zinc finger | C2H2-type 4 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000329613 | + | 0 | 2 | 994_1017 | 10 | 1032 | Zinc finger | C2H2-type 5 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 215_239 | 13 | 3455 | Zinc finger | C2H2-type 1 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 275_299 | 13 | 3455 | Zinc finger | C2H2-type 2 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 380_404 | 13 | 3455 | Zinc finger | C2H2-type 3%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 926_948 | 13 | 3455 | Zinc finger | C2H2-type 4 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000371497 | + | 0 | 3 | 994_1017 | 13 | 3455 | Zinc finger | C2H2-type 5 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 215_239 | 10 | 1012 | Zinc finger | C2H2-type 1 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 275_299 | 10 | 1012 | Zinc finger | C2H2-type 2 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 380_404 | 10 | 1012 | Zinc finger | C2H2-type 3%3B atypical |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 926_948 | 10 | 1012 | Zinc finger | C2H2-type 4 |
| Tgene | >TSHZ2 | chr20:47580435 | chr20:51870038 | ENST00000603338 | + | 0 | 3 | 994_1017 | 10 | 1012 | Zinc finger | C2H2-type 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARFGEF2 | chr20:47580435 | chr20:51870038 | ENST00000371917 | + | 7 | 39 | 654_785 | 302 | 1786 | Domain | SEC7 |
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FusionGeneSequence for ARFGEF2_TSHZ2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000371497_chr20_51870038_+_1324aa MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPG SHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGS NKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLR PTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFA DSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQS LSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLE NTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAV KECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSV LNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHA LSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQE RMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEI >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000603338_chr20_51870038_+_1324aa MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPG SHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGS NKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLR PTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFA DSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQS LSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLE NTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAV KECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSV LNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHA LSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQE RMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000371497_chr20_51870038_+_3972nt ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000603338_chr20_51870038_+_3972nt ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000371497_chr20_51870038_+_12167nt ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG GATGAAGAATAGCTCTGCAGGACGAATGCCTTAGTTTCCACTTTCCAGCCTGGATCCCCTCACACTGAACCCTTCTTCGTTGCACCATCC TGCTTCTGACATTGAACTCATTGAACTCCTCCTGACACCCTGGCTCTGAGAAGACTGCCAAAAAAAAAAAAAAAAAAAAATCACCCCAGC CATTTCTCTTCATCCTCACTAACAATTTGGTAATGAAGTATTGATTTCCACTTCTCTGCTTATGGGCGGTATTAGATTTTCATTGATAAA TTGCAATGGGGCTGTCTCGTCTCCACAGTACCCTTTTCACTGTCACAAGAAAACAAAGTGCCACCGAAGAAAAGTAATGACTGAGAGCAT TGATGTACTTATTTTGTCAGTTTGTAACAGGAAAGTGGGGGGGAGTCTAAGTCTTCATAGTCTAATGTCCAAGTGGGTTGCACTAGATGT AGACACTTGGAGGCTTACTTTTCATGGTAATGTCCATTTCCTATTTATAACCCCTCTGGGAACGTTTGTCTAAAGGAAATGTTTCTGTTC AGTGTAACAATTACAGTTGCACCTGGATTGCCCAGTCCTGCCCCTGCACTAGGGGACCATTAATCACTGCAAAGTAGAAGAATTATTAAG TTAAACCAGAGTTTGAGCCAAGAAAACCCCTGAACAATGTTCATCTTCTGTGAAACTTGCTCAAATAGTTAAGCTTAACCATGTTGCTGC CAAAGACTTTTCCTATGCAGTGGTGGGGCACCTTGATCATCATCATTATCTTGATTGGCTGAAAAAAAAATAGTTTTAAGCACACACCAC TGTCTATGAGAACTGCAAATTGGGAGAATAGGTGAAATGCAGAATCTGAGAGAACGCGAGAAGATGAGATCATTACAGGGTGGAAAGTTC TGCAGCAGCCTTTTCTGGTAATCCCTTTCTGCAGAACCTGATGTTTATGGGCTCTAAAACGCAGCTTAGCTTTAGAAGCAACAGAAAGCA TGAAATAGGGTGTCCATTTTAAATGTGTTCCTGCAACTTTTTTCATTAAAACTTTGAGGGCCCAATTTTAATTTGTGGAATATTCCCGTT AATAATGAGATCTAATTAAGACATCCATTAAAAGCCCGTTAAAGTTAATTTAACGTAAAAATTCCAATAGAACTGTATTAGATTTTCTCC ATTAAATTAACGTTATGGATTTTTAACGGATGTCTTAATTATACGTTATTATTAACGGGAATACTGTATTACACAGATTAAAATCAGGTC CTAAGTCAACTTGGAAGAGCTAAGAGCATGTTTTAATATTAAAAGTCTTGCATACCTAGTGCACAGTTTGGAGACGCAAGGATAGATCTG TTTACTCTAGTTGAACATTTTCTATACAATTGAAAGCAACCTATAATAGATAAATCCATCATTGCATTTAAACAATGAATTTCCTTATTC TCAAAGGACAAATACGTCTGGATTATGTGGTAAATTGCTACTCAGCTATGGTGAAATATTTATACTATTCTAGGCACAACACTAGGAACT AGGTGATTCTGAAACAAAAGGAATATTTTCTGTTGTTGCTTTAATTACCAAGGTTATTTTTTTTTAATCTCAACACTGACAAAATGAAAC CAAATATCTCTTCCTCACCATTTCTCAAGGAGGCTGCCTGTTGGAATTGTTTTGGAAATTTTGACATGATCCCTAAATTCAACATTGGGA TTAAAAAAAAAAAAAAACTTCTTATTTACCTCCTAGGGAAAGTGTTGCCCTTATGCCACATATAATAGCAAATTGCTTTTTTTATGGCAT GCATAACCTAGATGGGAAAAAATATGGCGCTTCGGGGAAGGAGGGAAAAAGTAAATGAAGTTCCAGGAATGTCATTCTGAAGTAATGAGG CATGGACAGAAAATATACCCCTCACATCATCGGATTGAGATGGCAGTCGAAATAGCTTCATTGAAGTGTCAGCACTCATCCATCAATCAA TCACCCACAAGGAAAAATAGCAACAGTACAACGGGGTGGCTTTTATGGGATTTACTCATGGGCATAGGGAATAGCGGCTCAAATGTAGTT CTGACATGAAAAGCAAGGTGCTGATATTATTTTTTATGATGGGAGGATCATAAAGTGAATTGAGAACAGTGAGGTCTGTCTTTGCTTAAC CTATTCAACCAGAAATGAATGGAGCTCGACTGGAAAGGAACAGTCTTCAGATGGGTTAAGATTGAAGGGTGGACTGGACTCTACTGAGCA CCGTCCTTCAACAAGGAAATTCTATTAAAGGAAAATCAATGCATTAGTATTGGGGTTCTCGTAGCTGTTAAAAATTGTCTGCTCCAATCC AGGGTTATTAGGCCAAAGTTACATAATTCAGATCTCACTGCAACCATCCAAAAGTGGATTCTCGAGCCCTTGCTCCAATGGGGGGAGGAG ATCAATACAATTCCCAATTCCATGGAAATTGTTTCCCTTCTAAGGAAGAAAAAATAAATCATCTGCTTCAACATATAATCGATATGGTTT TGTTAGCGTAATTTCTATGGTGGGTGGGGTGGGAGGTGAGAGAAAAAAATATTGATAAATTTGGTAAGACAGGTGAATTGCCGCCTGGCA ACCGTGCATGTCACTGCCGAGGGATGGCTGCTAAGGTTCACCTTAGAAAACAAGATCTGGGCTGGCACTGGGGCATACATCACCACTCAG CATATTCCTAGAGGCCAGGCCTGTCTTCACTCAGCCAGCCCTCTGAGGCTTCTAGAAACTTCTTTCTGGAGGAAAAAAACTAAATAACAT AAACTCAGGAGAATGTCTTTACCCACCTTCATACCACTGCTTTCTTTTTGCTGAATAAAACACAGTTCTGATAAGTAAGAACTTTAGAAT TGGAAAGGAGGCTGACATGCAAATATAATGCAAATTACCCTCAAGTATCGCCATTCTTCCACCACCTCTTGGTACCAGTGAGAGCGAGAG ATTGCCTTTTCTTCCCCATCCCTCCTTCCAGCTAAGACCACCAACCAGCTGCAAATTGAGATGTCCATTTAAAAATTTATATGTCAATAT TTAAATGTTACATATTTGGCCCTATTTTGTAGTTCAGCAAATCCTCCAAATACACAGCATGTTACAAGGCACTGGTGGCACAGGGCACAA CAGGAAATGATATTTATTTAGCAAATTCATTTAACAAATATTATTGGGCACCTGTTATGTGAGACACTGTCCTAGGCACTGTGGGATAAC AACAGCAAACACTTCACACAACAGCCTGGCCTTCCTGTGTTTTACAACAGCTCCTAAAGATAGCTGATATCAAGACATTTGAGGGACACA GTTCATGTAGAATCAAAATATTAGTATTTCAGAATAAGGATTTTTTTTCTGAAAAGCATACAGAGAGGAAACAGCTTAAAAATAGGTCAA GACCTAAAAACAGAATATAATCACGGAATAAACTGGATAACCCAGACAGTCCCCACAGAATTTCTTTCAGGTCACAGATTTCTTAAAACT CACCCCCAAAATGTGCCTGCTTGGTTGTTTGAATCTTGCATAATTAATGTCACAGGCGCAAGCCGCTGAACTTAGTTGAGATGCAGAAAA CAAACAAATGCAATGACATATCTGAGAAGCATTTATGTAACTCCGGTTAAGTGGTGAGGAGGGGTGTGTGAAGACAGTGTGCATGCATGA GTGTGTATTCATATATATGTGTATACATATGAATTTCACTGTTATTTTCCAGGGTCTATGGACAATGTGGCAGTAAGAGTCTATGATGTT CTGAAACTTTTCACAGTAAATCCAAAGATTACAGACCTTACAAGGTGCTTGCATTCTGTTGCTTTTCCATCTGTCACTTCTCAGGTTATT TGACTGTGTTCAAACCTTCTTTTCTTTTTCATTGAGTTTCATTTTTTAAGCTTGTTAAATGCTTTTGTTTAAAAAAAAAAAAAAAACCCC AAATGTCATTTTTCACATTATCCTCTCTTCTCTGCAACAAGGATAGTAAGATGTAGATGAATGCAAAAATAATAACAACAATAAGGAAAT ATATTAAAGCTTTAAAATATGCACATATGTAGTTCTAAAGAGCAATAACGGTAGTATCTATTTCGAACATGCATTAGGCAAAAAAGAAAT CAAAACTGAAATTTTCGTGTATTTTTCCCCTTGTAAGATGTTCAAATGCTAACTTCATTTTCTCCTTTCCTCTATGTGGCACTTTCTCAA AATATCTATGAAATACTTTTAGACAAAGATTGAGCTGGAGAAAGAGATACAAATTTCCATCCCCCCAGACAGAGAGACATATTTCCATTG TAGGAAGGCATTAAACATTTTGAAACTTGTGAATCATCTTTAGAATTTCTACTGGGGAATTTTACTTCTTCATCCAAAGTAAAAGCCACT TATCTCCTTTGGTTCCCAGTGACAGATTCAGAGGCATACGCAGATATACAATTTTCAGGCTCTAGTTAATCTTCTTCCAATAGTTACGAA CAATGGGCTAACAGGCGTGGGTGTTTCTCCAAAAATTATTCATGCACAAGGCAGCCCAAAGCTTCAGGGAAAACTAGAAATGTGTTATGG ATTAGAATAGGACTGTTTTAAAATGCTAGTACCAGGTGGAACGCTATTTCTGCAACAGGACTCTGTCCATTTCCTTTGGAACAATATATT CCAAGTAAAATGGCTCTTCCAAGGAATGACACCTTTACTTGACACCCTTCGGCATACAAATGATTTTACCAATAGCCATGATTATTATTA AGGCCTTTTAAAATACAGGCTGTTTGAAAAAAGACAGATTAAATATTCACAGCCTTTGTATCATGGTTATTTGCTTAAAACAGCTTTTAG AAGTACAAGTAATAACTTTTTGATAAGAAACCCCAGGAGAAACTTTTTGGTAAGAAACCTCAAAAAATTTGAACAAAGGCATTACAAAAA AAAAAAAAAAACTAACCACTCCATTCAACTCTCTCAGAAAATAAATTTCAATGTGTTCAATGAATTGTCTTGAACCTGAAACCTGCATTT AGATATCAGTCCCCTGCCAATAGCTAATATTAACAGAATTTGAACAATCATACAATTATGTCTCAAATGTGAAGACTTTGTACAGTAATA TTTTCACTTTCTAAATGACCCATATAACATTCAGGAATTATAGATGTGTATGTATATTTTTTAAGTACAGAAAGTTCAGCCAGTCTTCAG AGAAGTAAAAGTGATGTCTATTGTGCATTGAAGTAAATATTACAAACATTCCAGTTTCGCAATACAATACTTGAGCTTTCGAACACCTCA GACACTAGAATGTGTAATGCGAGTCAAAAAAGCTGACATACAAAACAATTCCCATTTGGCTCAGGGTTCCTAAATGTCACAATATCTTGG GTAAAATATACTTTTTGATTTCCTGATGATGTCCTTCTAATCCCTTCTGACTTTGATTCCTAACAGCCAGGCACTGTTGACATGAATCAT TAACTTCCAAACCCCTTTAAAATCAAGAAGCTAGGTGATCATACAGTCATTTCAATGGCCAACCAGTTCTTGCTCTACAGAGCTTTTACA CCTTTTTGGGAAACCTGATATCAAACACATTTATGTTATATATTTGCTCCCTTGCATTAATTCTAGATTTTTTTTTAATTTCTTTTAGAA AGGGCAGGGGGGAAGTGGGTCAGAGCAAGGTTCAAGAATCACATTCATCCTTGCTCTAAAGTGTTTACTTGCCAGCAAAGAAAGGCAAAC ACATTTTTATATTCAGAAAGCAGACCGGTCATTTTCAAAGAAAAATGACTGCAACCATGCCTGTAGAATGTTTCTGTGCAAGCGCACTAA TTTTCTATCACCTGCATGCTGTATATAATACATTTGCCTGTATACTAGGAAGAAAAACCAGGCTGTTTTCCCTGAGTACAATGCAGCTTG GATGGCTGGGAGCGTAAGCCTTCCGTGCATTTTTATAGTGTACATATTTGTATATACTAACTATATCGCCATGTATGAACACAGATTTTG TTATATTTGCTTGTTTCTGTTTCCTACCAAACTGGCCCACAATGGGGATTCTTTTGTATAGAAAAAATATGCTTGTAATTTTTTCCTGGT CATTCTCTTTCAATAGCTTATGAAAGAATTAGATCTGAGTTTACAAAGAAACTATAAGAACCAAGTTTGTCTGTCTGCATGAGTCCCGTC CAATTGCTGGATCTAGGGAGGAACCAACTTCCTAATTCAGAGTTTTCCTTTTAAAGGCATGCTTTACCCCCATGGGAAAACTGCACACTC ATCCATGTAGAATTATTCTCTTTGTATTTTATCTAATAGTGCCTGAAAATTTTTTTAATGTCTTCTTAGAAGAAGAATTCATAATTGTCA AAATTTGAAACATTAGCTTAATTTTGTTTTTATGACCTCAAGATTCTTCTCCTTATTTATTCGGTTGCTGTTGTAATGGGGCCCCAGGCC ATTCCTGACATCGGCGTGTTCTTCTTCTGCATTAAGGATGTTTTTGAAATTACAGAGATTATTGAGCCAACAGGCTGTTTTAATCAAAAC CATGTTTCACTTCTTTTTGATGATTATAAATTGTCCTTGCAATGAAAAAAAAAAAAGAACTTTTCTGCTAGGAAGATTATACCACCCTGT GGCCAAACAGATTCATCACAGATAGGCATCTATGCCCATTTCTCTGGGATCTGGAAAATTCTTCCCTTGGCTGACCCCAATTTCTTTTAC TCCCCATTATCCTGAATATTAGCTTTCAATGCAGTCACTATTTGACATTTCCAAAGGCTTTGCCGCATTGTCACTGCCCAAAGACAAACA ACCACTGGAAATGATGGCTTTCCTGCTTGAAACGAAGGGGGCCAGGTGCAGTGGCTCAAGCCTGTAACCCCTGCACTTTGGAAGGCTGAG GCAGGCGGATCACTTGAGGTCAGGAGTTTCAGACCAACCTGGCCAACATGGCAAAACCTCGTCTCTACTAAAAATACAAAAAACATTAGC AGGGCATGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAGCCCGGGAGGCGAAGGTTGCAGTGA GCTGAGATGGTGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTGTCTCAAAAAAAAAAAAAAGAATGGATTTTCAGAAAAAGTG CTCCCTTTCCTGTCCTGTGGTGCCACCATCCTGTCCTCCTTCGTAATCATGAACAATCTGATCTTGAACTCCCACATAACTTAAATCAGG CAAAAAGAAACATTCACAGCGTCCCCTTGCTGAATAAAAATGACTTTGTTTGGAGGCACTTAAGATGTATGCCTGTGTGTGGTGCCGCAG CATTGAAATTATCTGTAGAAGGGGAATTTTTTTTAAAAATACAATTTTATCACTAGAAATAAATTCCGATGGTGGAAACGAAGAAAACCC TTAAATTATATCACAAAAGCCATTATTTTTTGCATCCAAAGAGTTTTTTTTTTTAAGGAAAATCATTCTACTTTGAGAACTGTAATTAAA GCCCTAAATAACAGACACTACTTTGTTGAGCTATTGTGAAAAAAAAACAACACATTCGCCAAGGTTATATGGAGCCCCTGATTTCCATCA AAAAGGTTTCTATAAGTATATTATTTACATTTTTATACATGATAACTCTTGCCTTTGTGTTGAAAAAAAAAAAGTCTCTTTTTTTTCCCC CACTCAGCAGTTATTGGAAATAGACTGTTCCCATCTGAAACCGTATCGTAATTTGCATCAGGAAACCCAACTGCTGACATTGAGGACCTG GGTGTGTTCAATTATGATTTTGCTGGAGGCTGTCCCTCATTTTAATGCTGCAGCTATTGAACCACCTTCCTGAAACCTAGCTGATACGGA ATAGCAGAGACATGCCTCTCAACACCATTAGCTTTGCAAATGGCTTCATTTCAGTCAACGTCGACTTCTGCTTTGGCCAATTGAAAAATG AAAATTAAAGGAGAGAAGAAAAAAAACACAGATGCACTTAAAACATGAAAAGAATTATTTATATGATAAAAATATATTTAGCTTTTCAAA GCACAAGACTGAATAGAAGTGCTCTTTTTATGCTTTCTGGAGATGTTACTGTTAAATGTCTTTCTACATCAGGCTTAATAAATCTGTAAT >In-frame_ARFGEF2_ENST00000371917_chr20_47580435_+_TSHZ2_ENST00000603338_chr20_51870038_+_4316nt ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG GATGAAGAATAGCTCTGCAGGACGAATGCCTTAGTTTCCACTTTCCAGCCTGGATCCCCTCACACTGAACCCTTCTTCGTTGCACCATCC TGCTTCTGACATTGAACTCATTGAACTCCTCCTGACACCCTGGCTCTGAGAAGACTGCCAAAAAAAAAAAAAAAAAAAAATCACCCCAGC CATTTCTCTTCATCCTCACTAACAATTTGGTAATGAAGTATTGATTTCCACTTCTCTGCTTATGGGCGGTATTAGATTTTCATTGATAAA |
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FusionGenePPI for ARFGEF2_TSHZ2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARFGEF2 | FKBP2, PRKAR1A, PRKAR2A, ARFGEF1, MYC, VCP, PRPF40A, PNPLA2, CDC73, FLNC, NUP98, NUP88, PAF1, SPACA1, TMEM171, CSGALNACT1, DNAJB2, HLA-B, SDF4, CD244, SLAMF1, DTNBP1, HLA-E, LDLRAD4, ANKMY2, SNW1, FLNA, GYPB, LAMP3, FAM131B, MRAP2, CD79B, EDNRB, SIGLECL1, TMEM9B, MADCAM1, VASN, PDCD1, ICAM1, TRIM25, BRCA1 | TSHZ2 | APBB1, PYCARD, UBE2I |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARFGEF2_TSHZ2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARFGEF2_TSHZ2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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