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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23513

FusionGeneSummary for NBPF11_GPR107

check button Fusion gene summary
Fusion gene informationFusion gene name: NBPF11_GPR107
Fusion gene ID: 23513
HgeneTgene
Gene symbol

NBPF11

GPR107

Gene ID

200030

57720

Gene nameNBPF member 11G protein-coupled receptor 107
SynonymsNBPF24GCDRP|LUSTR1|bA138E2.2
Cytomap

1q21.2

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionneuroblastoma breakpoint family member 11neuroblastoma breakpoint family, member 24protein GPR107lung seven transmembrane receptor 1
Modification date2018051920180519
UniProtAcc

Q86T75

Q5VW38

Ensembl transtripts involved in fusion geneENST00000604938, ENST00000401010, 
ENST00000339388, ENST00000369323, 
ENST00000605317, ENST00000479926, 
ENST00000604894, ENST00000401009, 
ENST00000347136, ENST00000372406, 
ENST00000372410, ENST00000415344, 
Fusion gene scores* DoF score6 X 9 X 1=546 X 6 X 2=72
# samples 126
** MAII scorelog2(12/54*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NBPF11 [Title/Abstract] AND GPR107 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW850213NBPF11chr1

146076151

+GPR107chr9

132873621

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000604938ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604938ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604938ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604938ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401010ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401010ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401010ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401010ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000339388ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000339388ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000339388ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000339388ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000369323ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000369323ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000369323ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000369323ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000605317ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000605317ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000605317ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000605317ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000479926ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000479926ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000479926ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000479926ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604894ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604894ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604894ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000604894ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401009ENST00000347136NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401009ENST00000372406NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401009ENST00000372410NBPF11chr1

146076151

+GPR107chr9

132873621

+
intron-intronENST00000401009ENST00000415344NBPF11chr1

146076151

+GPR107chr9

132873621

+

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FusionProtFeatures for NBPF11_GPR107


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NBPF11

Q86T75

GPR107

Q5VW38

Involved in Golgi-to-ER retrograde transport. Functionsas a host factor required for infection by Pseudomonas aeruginosaexotoxin A and Campylobacter jejuni CDT toxins.{ECO:0000269|PubMed:25031321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NBPF11_GPR107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NBPF11_GPR107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NBPF11_GPR107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBPF11_GPR107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource