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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 23470

FusionGeneSummary for NAV3_CHST11

check button Fusion gene summary
Fusion gene informationFusion gene name: NAV3_CHST11
Fusion gene ID: 23470
HgeneTgene
Gene symbol

NAV3

CHST11

Gene ID

89795

50515

Gene nameneuron navigator 3carbohydrate sulfotransferase 11
SynonymsPOMFIL1|STEERIN3|unc53H3C4ST|C4ST-1|C4ST1|HSA269537
Cytomap

12q21.2

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionneuron navigator 3pore membrane and/or filament interacting like protein 1unc-53 homolog 3carbohydrate sulfotransferase 11C4S-1IgH/CHST11 fusioncarbohydrate (chondroitin 4) sulfotransferase 11chondroitin 4-O-sulfotransferase 1
Modification date2018052320180519
UniProtAcc

Q8IVL0

Q9NPF2

Ensembl transtripts involved in fusion geneENST00000536525, ENST00000397909, 
ENST00000228327, ENST00000266692, 
ENST00000552300, ENST00000541270, 
ENST00000547956, ENST00000549260, 
ENST00000303694, ENST00000546689, 
ENST00000550711, 
Fusion gene scores* DoF score15 X 9 X 3=4056 X 6 X 3=108
# samples 136
** MAII scorelog2(13/405*10)=-1.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAV3 [Title/Abstract] AND CHST11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHST11

GO:0030206

chondroitin sulfate biosynthetic process

11056388


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A48N-01ANAV3chr12

78225484

+CHST11chr12

104995684

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000536525ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000536525ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000536525ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000536525ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
5CDS-intronENST00000536525ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000397909ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000397909ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000397909ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000397909ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
5CDS-intronENST00000397909ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000228327ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000228327ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000228327ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000228327ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
5CDS-intronENST00000228327ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000266692ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000266692ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
Frame-shiftENST00000266692ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
In-frameENST00000266692ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
5CDS-intronENST00000266692ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000552300ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000552300ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000552300ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000552300ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-intronENST00000552300ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000541270ENST00000547956NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000541270ENST00000549260NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000541270ENST00000303694NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-3CDSENST00000541270ENST00000546689NAV3chr12

78225484

+CHST11chr12

104995684

+
intron-intronENST00000541270ENST00000550711NAV3chr12

78225484

+CHST11chr12

104995684

+

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FusionProtFeatures for NAV3_CHST11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAV3

Q8IVL0

CHST11

Q9NPF2

May regulate IL2 production by T-cells. May be involvedin neuron regeneration. {ECO:0000269|PubMed:16166283}. Catalyzes the transfer of sulfate to position 4 of theN-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitinsulfate constitutes the predominant proteoglycan present incartilage and is distributed on the surfaces of many cells andextracellular matrices. Can also sulfate Gal residues indesulfated dermatan sulfate. Preferentially sulfates inGlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as anacceptor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHST11chr12:78225484chr12:104995684ENST00000303694+03124_13039353Nucleotide bindingPAPS
TgeneCHST11chr12:78225484chr12:104995684ENST00000303694+03186_19439353Nucleotide bindingPAPS
TgeneCHST11chr12:78225484chr12:104995684ENST00000549260+03124_13034348Nucleotide bindingPAPS
TgeneCHST11chr12:78225484chr12:104995684ENST00000549260+03186_19434348Nucleotide bindingPAPS
TgeneCHST11chr12:78225484chr12:104995684ENST00000303694+0338_35239353Topological domainLumenal
TgeneCHST11chr12:78225484chr12:104995684ENST00000549260+0338_35234348Topological domainLumenal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+1401562_1653812386Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+1401794_1861812386Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+140679_707812386Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+1391562_1653812364Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+1391794_1861812364Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+139679_707812364Coiled coilOntology_term=ECO:0000255
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+1401032_1560812386Compositional biasNote=Ser-rich
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+1401694_1699812386Compositional biasNote=Poly-Lys
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+1401867_1885812386Compositional biasNote=Ser-rich
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+140618_621812386Compositional biasNote=Poly-Gln
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+1391032_1560812364Compositional biasNote=Ser-rich
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+1391694_1699812364Compositional biasNote=Poly-Lys
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+1391867_1885812364Compositional biasNote=Ser-rich
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+139618_621812364Compositional biasNote=Poly-Gln
HgeneNAV3chr12:78225484chr12:104995684ENST00000397909+14077_184812386DomainCalponin-homology (CH)
HgeneNAV3chr12:78225484chr12:104995684ENST00000536525+13977_184812364DomainCalponin-homology (CH)
TgeneCHST11chr12:78225484chr12:104995684ENST00000303694+031_1639353Topological domainCytoplasmic
TgeneCHST11chr12:78225484chr12:104995684ENST00000549260+031_1634348Topological domainCytoplasmic
TgeneCHST11chr12:78225484chr12:104995684ENST00000303694+0317_3739353TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCHST11chr12:78225484chr12:104995684ENST00000549260+0317_3734348TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for NAV3_CHST11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_119aa
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKSCGGIPLVW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_359nt
ATGCCTGTTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGC
ACTACTGGGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCA
ACCTGTGAATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_790nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT
GGTTGCTTTCTCCGTCACCCTTTTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGT

>In-frame_NAV3_ENST00000536525_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_658nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_790nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT
GGTTGCTTTCTCCGTCACCCTTTTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGT

>In-frame_NAV3_ENST00000397909_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_658nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_790nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT
GGTTGCTTTCTCCGTCACCCTTTTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGT

>In-frame_NAV3_ENST00000228327_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_658nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000547956_chr12_104995684_+_790nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT
GGTTGCTTTCTCCGTCACCCTTTTTCTATGTAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGT

>In-frame_NAV3_ENST00000266692_chr12_78225484_+_CHST11_ENST00000546689_chr12_104995684_+_658nt
AGATGCAGGGAAGTTTTGCCTCTTCCTGAAAATTATATTATTAGCTTTTTAAAAATCAGGATGACTGCTAGTTTTGTTTAAAGTATTTGT
TCTGGAAATACTAAAGTTGGAGTCTACCAGACTGAGGTTAGAAGCATTTTCTTTGGCAGCAAGAAGATAATTTTATAGAAGCCATGCCTG
TTCTTGGGGTTGCCTCAAAACTGAGGCAGCCAGCTGTTGGGTCAAAGCCTGTGCATACTGCTCTTCCGATACCAAATCTTGGCACTACTG
GGTCACAGCACTGTTCTTCAAGACCTTTGGAACTTACTGAAACAGAGAGCTCCATGCTTTCTTGTCAGCTTGCGTTAAAATCAACCTGTG
AATTTGGAGAGAAGAAACCCCTCCAAGGAAAAGCCAAGGAGAAAGAAGACAGCAAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTG
CTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTT
TTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGT


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FusionGenePPI for NAV3_CHST11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NAV3APC, TFAP4, MAPRE1, TRIO, KRASCHST11HLA-DPA1, SDF4, YWHAE, SLC2A12, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NAV3_CHST11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NAV3_CHST11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAV3C0007134Renal Cell Carcinoma1CTD_human
HgeneNAV3C0027412Opioid-Related Disorders1CTD_human